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Polio Bulletin - 2006, Week 52

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More Than 10 Years Without Indigenous Wild Polio Virus! Date of onset of last indigenous wild polio virus case: AFP cases investigated since: 19 March 1997 65,981

Poliomyelitis Surveillance - Report for Polio Week 52, ending December 31, 2006 (as of 25 Jun 2007) Table 1: Classification of AFP cases with onset in 2006 and key surveillance indicators Reported AFP Expected AFP Reported AFP 2005 2006 2006

Classification Confirmed Polio Poliocompatible Non-polio (Discarded) Pending

Indicators Non-polio AFP % with 2 % Reported Rate/ 100,000 < Specimens w/n Within 14 Days 15 yrs 14 Days of Onset of Onset % With Followup % Inadequate Stools With Follow-up Pending Classification > 90 Days After Onset

Latest Report Date

Australia Brunei Darussalam Cambodia China Hong Kong, SAR, China Japan Korea, Republic of Lao PDR Macao, SAR, China Malaysia Mongolia New Zealand Pacific Island Countries Papua New Guinea Philippines Singapore Vietnam Western Pacific Region

31 2 112 5,425 22 0 17 59 1 140 8 9 4 18 352 10 470 6,680

40 1 52 2,648 9 174 90 27 1 90 7 8 10 24 320 7 321 3,829

43 5 111 5,635 14 0 33 50 3 121 7 8 23 13 437 5 503 7,011

0 0 1* 0 0 0 0 0 0 0 0 0 0 0 0 0 1*

0 0 0 10 0 0 1 0 0 0 0 1 1 4 0 0 17

43 5 110 5,625 14 33 49 3 121 7 8 22 12 433 5 503 6,993

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

1.08 5.00 2.13 2.13 1.56 0.37 1.85 3.00 1.34 1.00 1.00 2.30 0.54 1.37 0.71 1.57 1.83

23% 40% 79% 91% 79% 85% 68% 67% 70% 71% 88% 30% 38% 83% 100% 95% 89%

56% 40% 86% 94% 79% 91% 74% 67% 88% 86% 63% 30% 77% 90% 100% 89% 93%

40%** 80% 100% 97% 100% 100% 72% 100% 100% 86% 100% 91% 92% 96% 100% 98% 97%

39% 100% 100% 94% 100% 100% 100% 100% 100% 100% 100% 94% 88% 97% 92% 93%

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

02-May-07 03-Jan-07 01-Mar-07 22-May-07 01-Mar-07 06-Mar-07 16-Jun-07 19-Jan-07 15-May-07 30-Jan-07 19-Feb-07 21-Jun-07 07-Jun-07 29-Mar-07 02-Mar-07 10-May-07

* cVDPV confirmed by lab; 1 more case in 2005 ** Follow-up is not required by the Polio Expert Committee if a case can be classified as non-polio AFP on the information available.

3.5 3 2.5 2 1.5 1 0.5 0 CAM CHN LAO MAA MOG PNG PHL VTN

100% non-polio AFP rate (2004) non-polio AFP rate (2005) non-polio AFP rate (2006) adequate stools (2004) adequate stools (2005) adequate stools (2006) 80% 60% 40% 20% 0% CAM CHN LAO MAA MOG PNG PHL VTN

Table 2: Laboratory investigation of AFP cases with onset in 2006 Country National AFP Cases with Lab1 Specimens VIDRL* VIDRL* NIID Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab Prov. Lab PHLC NIH NIID IMR, KL PHI IESR VIDRL* IMR, PNG RITM SGH NIHE PI 22 5 110 228 19 88 118 120 285 331 283 36 474 155 578 210 245 252 162 72 96 84 27 34 149 406 32 178 319 36 2 71 256 194 17 33 47 122 6 6 14 11 456 12 301 207 6,909 AFP Cases Positive For: P1 P2 P3 Polio Mix Polio/NPEV Pending % Positive for NPEV % Results Reported w/n 28 Days Latest Report Date

Australia Brunei Darussalam Cambodia China, Anhui China, Beijing China, Chongqing China, Fujian China, Gansu China, Guangdong China, Guangxi China, Guizhou China, Hainan China, Hebei China, Heilongjiang China, Henan China, Hubei China, Hunan China, Jiangsu China, Jiangxi China, Jilin China, Liaoning China, Neimongol China, Ningxia China, Qinghai China, Shaanxi China, Shandong China, Shanghai China, Shanxi China, Sichuan China, Tianjin China, Tibet China, Xinjiang China, Yunnan China, Zhejiang Hong Kong2, SAR, China Korea, Rep. Of Lao PDR Malaysia Mongolia New Zealand Pacific Island Countries Papua New Guinea Philippines Singapore Vietnam, North Vietnam, South Total

0 0 0 2 1 1 2 0 1 2 1 1 5 0 2 0 1 1 1 0 0 1 0 0 0 2 0 2 1 0 0 1 1 1 0 0 0 1 0 0 0 0 0 1 1 1 34

0 0 2 5 2 1 2 0 6 2 3 0 5 1 12 1 9 9 5 1 2 0 0 0 1 14 3 2 4 1 0 0 0 2 0 0 0 0 0 0 0 0 1 0 2 0 98

1 0 0 2 0 0 1 0 1 3 3 0 11 0 6 0 1 6 8 2 0 1 1 0 2 4 1 2 1 0 0 1 2 2 0 0 1 1 0 0 0 0 0 0 1 0 65

0 0 0 1 0 0 4 1 5 3 0 0 4 0 9 0 5 1 0 2 0 0 0 0 0 2 1 2 2 0 0 1 1 0 0 0 0 1 0 0 0 0 2 0 0 0 47

0 0 2 0 0 0 0 0 0 0 3 0 6 0 0 0 0 1 2 0 1 0 0 0 0 6 0 0 2 0 0 0 6 1 0 0 0 0 0 0 0 0 0 0 0 1 31

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

17% 30% 22% 10% 11% 6% 3% 4% 8% 8% 7% 13% 13% 7% 16% 6% 10% 15% 19% 8% 8% 0% 22% 10% 10% 5% 0% 7% 12% 4% 0% 11% 14% 8% 9% 0% 26% 2% 17% 0% 20% 14% 5% 5% 19% 16% 10%

100% 80% 97% 97% 100% 95% 95% 97% 95% 100% 97% 92% 97% 100% 96% 94% 99% 93% 92% 94% 97% 100% 96% 96% 94% 95% 89% 98% 81% 97% 0% 98% 93% 93% 94% 80% 96% 96% 100% 100% 100% 90% 100% 100% 99% 100% 96%

08-Feb-07 03-Jan-07 01-Feb-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 22-May-07 06-Mar-07 26-Jan-07 13-Apr-07 08-Mar-07 25-Jan-07 03-Jan-07 03-Jan-07 07-Jun-07 13-Mar-07 16-Jan-07 22-Mar-07 31-Jan-07

* Specimen test reports are under the guidelines of the June 2006 test algorithm.

1

Acronyms: VIDRL - Victorian Infectious Diseases Reference Laboratory, Australia NIID - National Institute of Infectious Diseases, Japan PHLC - Public Health Laboratory Centre, Hong Kong SGH - Singapore General Hospital IMR, KL - Institute of Medical Research, Kuala Lumpur IMR, PNG - Institute of Medical Research, Papua New Guinea IESR - Institute of Environmental Science and Research, New Zealand RITM - Research Institute for Tropical Medicine, Philippines PHI - Public Health Institute, Mongolia NIH - National Institute of Health, Seoul NIHE - National Institute of Hygiene and Epidemiology, Hanoi PI - Pasteur Institute, Ho Chi Minh

2

Includes cases from Macao, SAR, China

Table 3: Intratypic differentiation of polio isolates from AFP cases with onset in 2006 Country Regional Reference Lab1 AFP Cases w/ Polio Isolates ITD Results 2 P1S P1W P2S P2W P3S P3W Pending3 Discordant4 VDPV Sequencing Not VDPV Pending ITD Results ITD Results ITD Results ITD Results w/n 14 Days of w/n 28 Days of w/n 60 Days of w/n 90 Days of Onset Receipt Receipt Onset

China Hong Kong, SAR, China Singapore Australia Malaysia New Zealand Pacific Island Countries Papua New Guinea Philippines Japan Cambodia Korea, Rep. Of Lao PDR Mongolia Vietnam Total

CCDC PHLC SGH VIDRL VIDRL VIDRL VIDRL VIDRL VIDRL NIID NIID NIID NIID NIID NIID

291 0 1 1 3 0 0 0 3 0 4 0 1 0 6 310

69 0 0 2 1 0 0 2 74

0 1* 0 0 0 0 0 0 1*

158 0 0 1 3 2 0 3 167

0 0 0 0 0 0 0 0 0

119 0 1 1 2 2 1 1 127 5

0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0

19 0 0 0 0 1 0 0 20

1 1 2

18 0 18

0 0 0

52% 100% 100% 100% 100% 25% 100% 100% 55%

77% 100% 100% 100% 100% 100% 100% 100% 79%

34% 100% 100% 100% 80% 100% 0% 91% 40%

57% 100% 100% 100% 80% 100% 0% 100% 60%

* Isolated by NPL from a child infected outside Singapore and seeking medical treatment in the country.

Table 4: Laboratory investigation of polio isolates from non-AFP cases in 2006 Country Regional Reference Lab Polio Isolates

ITD Results P1S P1W P2S P2W P3S P3W Pending Discordant

Sequencing VDPV Pending

China Hong Kong, SAR, China Singapore Australia Malaysia New Zealand Pacific Island Countries Papua New Guinea Philippines Cambodia Japan Korea, Rep. Of Lao PDR Mongolia Vietnam Total 1

CCDC PHLC SGH VIDRL VIDRL VIDRL VIDRL VIDRL VIDRL NIID NIID NIID NIID NIID NIID

81 72 4 1 15 0 0 0 0 2 0 1 0 0 0 176 2

29 41 1 0 5 1 0 77 ITD Results:

0 0 0 0 0 0 0 0

17 15 1 0 7 0 0 40

0 0 0 0 0 0 0 0

35 16 1 1 3 1 1 58

0 0 0 0 0 0 0 0 4

0 0 0 0 0 0 0 0

9 5 1 0 0 0 0 15

8 0 0 8

0 0 0 0

Acronyms: CCDC - Chinese Center for Disease Control and Prevention VIDRL - Victorian Infectious Diseases Reference Laboratory, Australia NIID - National Institute of Infectious Diseases, Japan PHLC - Public Health Laboratory Centre, Hong Kong SGH - Singapore General Hospital

Antigenic ITD <> Molecular ITD for all serotypes. Cases with discordant ITD results may be counted more than once under "ITD results", ie. as "discordant" and "S" or "W", depending on the results of sequencing.

S - Sabin; W - Wild 3

Pending ITD = Pending Antigenic ITD and/or Pending Molecular ITD Total Pending Cases = Pending ITD + Pending Sequencing 5

Based on year of collection of sample, if available. Otherwise, based on year of receipt at reference laboratory.

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