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(c) rhyroid ~Jand, ;.oaK.tali et ;11, (21) " ",du"" ..1 • p""-al,,,,,e <tuth' of Ix-"'KJ' ' \lmoun of ' he tl"m,d gland atnollK AilS partidpa"'.. ,n ;.o"l("-'>dlJ. ,tnd found a ";Knif ..-anl "' ''''' ....'1"",... in ' hc P'<"' odrr>rc "f ""lid nodul... "I"lhc thlTI,id Th e .. ~ i d n..dub had ,,,,,- btt" e>t>.mi",-d hi" ol"Wc;llI;'. b'" "'.,,)' of ,lIcm p'ol><lhly ....,-c aclcn"ma. and a 'dali<>I1shiJl I:>t·""'....n ",I..n"n", and n.di"';' ,,, u l"',,,.... " ....' " 'IOl' '''''d
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Summary ThIs ar\fCla summari zes ee resuu s 01 a 'acent stuay 01 atomiC bom b f adiatiOn and "",,-cancar dlseases in tt>e AH $ (MUll Health $Iud y) populahon b y !he RERF (Radl!ltion EH ect s Research Foor>dation)along w ~ h a Il'l"" ",al diSCussion 01 p revious stud",S,
ques et Ies malad"'S roocercerecses ceos l'Etude sur la san~ adu lte-s (AHS ) e la Fondatoon pou r la rechefche sur les aflats des rayonnements et tM en mllme lamps unb iian geMral clas ~udes procedantes
oes
The associa tion at atomic bomb radiat"" and cve was exam ined by incOdence Slu<loes and prevalenCe stud.... 01 vanous endpoints 01 atherOSClerosis. such as MI, strol<e. aortic arch calCilOc:a\fon. isolaled SyslohC Ilype<. tension. and pul se wa..... veloc ity. ancl. althougl1 the e xcess was small. all en<lPOiflts indiCated an increase 01 cve in the ooavily group. Because at tt>e consislency 01 !he ,esu~s , it is almosl cerla,n thal cve is higher among alomic bomb SUIViVOl"S . Howevar, all cve , is!< factors associa ted with I~esryle Md r\OlneceSsarily boo n alljusted tor in studills to c1ale . ancl it is c1i11ic u ~ al p<esent 10 cc-ciuoe thal lhe increase In CVO among survivors was a direct eHed 01 radiation,
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Recom studies M ..... demonsl ral&<! almost cerlalnly ltIal uler ine my<ma is more trequen1 alom ic bomb $lJ(VJll()(S, It ea-ox, at present , be concluded that ut",· loo myoma is caused b y'ac!iation, because there are 00 ,eported stud ies 01 Olf>e-r expose cl popuIations. Funf>e-r analyses inc luding lhe rote 01 COIltour>ding t ~t()($ as well as molecular approaches ara needed to verily this ' acliahOn etl ecl
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t'aseccetoo <le n n adlal iOO due eu' bombarderneots atom;ques el des matad.... C8,dio--vascula;res a ~I~ e""rrriMOO par des atvdes POr\at1t sur l"inciclanc e al la prevalenca differents cr<leres de I'atha-rosclol<ose. comma les in(arc1us du myocaroo, Ies !>CCidents ~ a s culaires cllr~bfau x . la calcillCa1ion <le ia crosse aorti· que, I't!ypenension Syslolique i&Olae et I'augmen lation de 18 Ir&quence du pouts at boen que I'a. ells Illt ("'bill. !OUS !as Oldoc.aleurs montraian1 ...., accroissemanl des maladies cardoo-vasculalres d ans le groupe qui avertele Jourdama<11 ax.posll. Du 1811 de la cohe«lnce des rl!sultats obtenus . ~ eSI prali~ certain que les maladies ca,d;o.vasculaires onl augmente crezes survivants clas bomttar<lemanls atomiques, Toute!<Ws, 10uS !as lac1eurs de risque des maIad.... cardo-vascul!lires li8es eu mode cia ~ie n'onl pas ""cement tait I'oo ;et d·..., el'J$ t-m <tans ee etuoes etlactuees e ca joI.o-, ast ddfICile a l'heure actoolle cia "",""lure que raugmentalion des malad<es carclio-~ascula.res ceee see SU/\fivanlS esl une consequenca d"acta cia rtrad tal ",",
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The ffNationship between atomic bomb ,atllalOn axpoSUra and hyperpa ral hyroiclism can now be saicllO ha..... boo n establlshecl in """" 01 tt>e strong Oose response. tt>e ag'eeme<1t WI\h '4suhs 01 studies 01 Olhe< popuIa· tions, !he high nSl< in !he l"JU"l9"r su<Vivors , and tt>e biologK:a 1plausib"ty. Future Slud .... by fOOOIcular approaches. ete., era reeoec 10clalerm ine the pathogenIC mechanism. Among 0I1ler ben;gn t'-""O<JrS. a Oose response !>as been demonsl raled tor tumours OIlhe thyroid, ston'laCh
Des etudes rl!Cenles ont monue presque cerla' nement que le my<>me ul8rin a augmen~ Chel Ies survivanleS des bombardements alomiques. On ne pe ul toul efois pas an concllx'e a l'heure actoolla que le myome ut,,,,,, eSl ooe QOfI&equence <le I'inadiation . a cause de reesanee oece type de menhon dens IeS eludeS portenl SU' d'autres populalions exposOOs. De nouve4les analyses , y canpris le rOle des tscteors <le QOfIlusion, ainsi que des approches motecuialles, ilOfIl necessaire-s pour ~e'mer celIe QOfI~uence cia nnadla1lOn. On poot <leSOflTlals dire que la relation enl r" raxpoMion """ rayonnem,mls due aux bombar<tements alomlQues et l'hyper parathyrOld le esl ~t a blOe compte 1<!flU d e la lorte r" lal oon <lose-<ePO"se, de la concordance evec Ies ,esu~ats des eludes t3J1eS sur d 'autres popule1ions. du ' isque eleve COUtu par IeS plus jeunes Sl>"V'vsnls " I cia la p lausrbd'te b lolog oque. IItaul enl repre<Klre<le """"alIas etude s b asees sur rap prQChe rno!liculai'a pour ck\lerm>ne< le mecanisme p altJogane. Parrni d'autres lI.rneurS bIlnignes L.<le roia""" <loserePO"se a ele prtllJYtle pour la ihyrolde. reseree et I'COI'aire 6ien que I'on ail entrepris moins d'8tudea que dens le cas du cancer, I'assoc iation ""Ir" rayonnemenlS el di\foef'SeS l\.rrleur!; benignes se d8gage netlemen1
ar>d COI'ary. Ahhough tewe< studies hava been COi"" o....cted lhan for cancer, a clear associat"" belw<!oo rad iatlOO aoo various benign tumours is emer gIng,
Conce<n"'ll the assoc ia1l0n belween alomic bomb radio ation exposu ra and cl>rOl"lic '""" diseases, tt>e rac ant O"ICiderlCe s1udy at membe rs 01 loo AHS population <lemonS lraled a signdicant Oose,esponse. BoIh chronic he patitIS and cirrhosis wera sug geSled as be .-.g associa ted with " .posura. The POSS;bi lity ltIallhe if>. crea sed occurrence 01 chron", '''''' dIsease. among the SUf'o'ivors may be due 10 he pat~IS virus IntectlOfl cannot be excluded, and !he ,,,SUh. 01 the ongoing hepahhS C virus an~body titr" stud.... are awa,t&<!.
R esume Profll des m,/,dles non c,nclreuSls chll /'S UfY!yants d,lIomll,rdements , tom/ques S Le pr lkenl artICle r$SVm8 les r$sU ~als de 1'llIude rll<:ente le ite SUr nrrad..toon d<Je aWl bombar dements atomi-
En ce qui concerne l'assoc ial On enl ra l'exPOSI\IOn aux 'ayonnements due aux bombardements atomiques et !as hepatopsltlies chronique-s. retucla n'lCente de I"inci· dence concernant des membtes la population de i'Elude sur la sante des aOuite-s a montre una relation Oose·reponse importanle 11 mele suwa'eque l"hepawe a. · chron ique corrrne la c;irrl'Io$e ela""'l associees e I" lX'Silion . La possibilite que l 'aug<nenlal iOn de I' appa r~ l ion des hi!pa topa lh>es chez les survivants sod due una .,Iaction par le virus <le l'Npatlla ne paul <'tlra e.clue. el on alieno IeS resuM IS des el udes eo Cours pour de1erminer le l lue en ""t,,,orps d~i ges contre le virus cia I'Mpa~te C.
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, 41 ( 1996)
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