Plan of action and budget for 1997

Onchocerciasis Control Programme in West Africa Programme de Lutte contre I'Onchocercose en Afrique de l'Ouest JOINT PROGRAMME COMMITTEE JPC - CCP COMITE CONJOINT DU PROGRAMME Office of the Chairman - Bureau du Pr6sident l JOINT PROGRAMME COMMITTEE Seventeenth session Cotonou. 24 December 1996 Provisional agenda item 8 tPcl7.4 ORIGINAL : FRENCH September 1996 PLAN OF ACTION AND BUDGET FOR 1997 I JPCL7.4 ONCHOCERCIASIS CONTROL PROGRAMME in West Africa PLAN OF ACTION AND BUDGET FOR 1997 WORLD HEALTH ORGANIZATION t\ I (i) TABLE OF CONTENTS 1. INTRODUCTION OVERVIEW OF THE PLAN OF ACTION OVERVIEW OF THE BUDGET FOR 1997 ESTIMATED COST BY PROGRAMME ACTTVITY Page 2 3 4 1 3 6 15 15 20 27 30 33 38 39 4.1. 4.2. 4.3. 4.4. 4.5. 4.6. 4.7. Vector Control Unit Planning Evaluation and Transfer Unit . . Macrofil Chemotherapy Project Office of the Director Administration and Support Services Unit Statutory meetings Capital costs I. II. Itr. IV. V. u. Vtr. vm. x. ANNEXES OCP ORGANIZATION CHART AVERAGE COSTS USED FOR BUDGETARY CALCULATIONS RATES OF EXCHANGE OF THE US DOLLAWCFA FROM 1995 TO 1996 . COST OF PERSONNEL FROM I992TO 1997 . AERIAL OPERATIONS FROM I992TO 1997 . MAP - PROPOSED VCU PLAN OF OPERATIONS FOR 1997 MAP - VCU SECTORS, SUBSECTORS, OPERATIONAL BASES FOR 1997 MAP - LARGE-SCALE TVERMECTIN TREATMENT PLAN FOR 1997 VEHICLES IN OPERATION FROM I992TO 1997 . 42 43 44 45 46 47 48 49 50 1 (iD LIST OF TABLES TABLE 1. BUDGET BY PROGRAMME ACTTVITY TABLE 2. BUDGET BY CATEGORY OF EXPENDITI'RE TABLE 3. BUDGET FOR 1997 - SUMMARY BY PROGRAMME ACTTVITY AND CATEGORY OF EXPENDITURE TABLE 4. VECTOR CONTROL UNIT TABLE 5. PLANMNG, EVALUATION AND TRANSFER UMT TABLE 6. MACROFIL CHEMOTHERAPY PROJECT . TABLE 7. OFFICE OF THE DIRECTOR TABLE 8. ADMINISTRATION AND SUPPORT SERVICES TABLE 9. OVERVIEW OF ADMINISTRATTVE COSTS TABLE 10. STATUTORY MEETINGS TABLE 11. CAPITAL COSTS Page .10 .12 t4 t9 26 29 32 35 36 38 40 .t a IJPCI7.4 Page 1 1. INTRODUCTION The Plan of Action and Budget for 1997 has been prepared on the same general format as in the preceding years of the fourth Financial Phase (1992-1997). The amount proposed for the 1997 budget is US$ 22,000,000, which is less than that approved for 1996 (US$ 24,278,000) and also slightly less than the amount projected for 1997, in the 1996 budget document. To a large extent this is due to the rationalization of the vector control activities leading to the closure of a zone office in Mali and of sectors and subsectors, in Benin, and Ghana in 1996. There has been a restructuring of the Programme with the merging of three technical units to form a Planning Evaluation and Transfer unit to give added impetus to the transfer of responsibility for recrudescence detection and control to ttre national teams. This has affected the presentation of some budgetary tables. 1.1. Vector control operations The budget for vector control activities for 1997, takes into account the closure of the Bondoukou and Kintampo subsector offices, the Parakou and Tamale sector offices in December 1996 and the closure of the zone office in Bamako in June 1996. The Western Zone headquarters is operating from Odienne in the premises formerly occupied by the aerial operations unit. 1.2. Planning Evaluation and Transfer Activities The Planning Evaluation and Transfer Unit (PET) is a composite Unit created towards the end of 1995 by merging the former Epidemiological Evaluation Unit, the Unit of Biostatistics and Information Systems and the Devolution Unit. The budget for this unit for 1996 was the result of the appropriate fusion of the budgets approved for the tfuee units by JPC 16. The newly formed unit worked very closely with the countries in 1996, in organizing national workshops to develop their national plans for taking effective charge of the residual activities of Onchocerciasis Control, such as decentralized epidemiological surveillance and putting in place community-based treatrnent with ivermectin. Support for these plans is taken into account in the 1997 budget. The other routine activities are included such as training in epiderr:iohgical surveillance and epidemiological modellhg. 1 JPCI7.4 Page 2 1.3. Short-term staff contracts This budget was prepared on the basis of hiring short-term staff on Special Services Agreements to fill vacancies that arise. Thus hiring will be on "Short-Term" contracts with nationally competitive salaries, as opposed to fixed-term "WHO" contracts with the United Nations salary scales. This will apply at all general service staff levels and also at the professional level. It will lead to a reduction of staff costs. 1.4. Capital costs It is proposed to continue the gradual reduction of the fleet in 1997 n line with projections for reduction in vector control and progressive devolution. It is necessary therefore to remove 93 vehicles which are already over 10 years old from the fleet, replacing only 63 of them over the two-year period 1997-1998. This accounts for the significant increase in capital cost in this frnal year before the start of the phasing-out period. t IlPCt7.4 Page 3 2. OVERVIEW OF TIIE PLAN OF ACTION The Plan of Action sets out the work which will be done by the various units viz: larviciding, planning, evaluation and transfer to countries of responsibility for recrudescence detection and control, entomological surveillance activities, applied research, epidemiological evaluation, ivermectin distribution, operationel research, epidemiological modelling, data processin g and administration. 2.L. Office of the Director ln 1997, the Office of the Director will continue to decide on the main orientations of the Programme, to define the general policies and to co-ordinate the management activities. The number of WHO fxed-term posts in the Director's Office will be reduced by four (i.e. one professional and three general service). The functions performed up to 1997 by the holders of three of these posts, will be carried out at less cost by a short-term professional and one general service staff member on a special service agreement. The liaison off,rce in Geneva will be maintainefl, but is cost will be shared with the WHO Regional Office for Africa, which will also use its services. 2.2. Vector Control (VCt) The Plan of Action for vector control activities is shown on a map at Annex VI. It may be summarized as follows. At the end of 1997, OCP vector control activities will have been terminated throughout the Original Programme area, except for nvo pockets: the Dienkoa, where ground larviciding is being done by 1fos national team of Burkina Faso, and the Keran, Kara and Mo tributaries of the Oti, in northern Togo, where there was reinvasion by infective flies from the South-eastern Extension area until 1988 when treatment started there. Aerial treament will continue in the southern extension area of C6te d'Ivoire, in the Western Extension area (Guinea and Sierra [.eone) and in the South-eastern Extension area (southern Ghana, Togo and Benin). The principle of rotation of the seven currently available insecticides will be maintained n 1997 . Vectron (etofenprox) will be used more in the zones of resistance to Abate and phoxim, thereby reducing the pressure of resistance on the organophosphorus compounds in discharges ranging between 15 m3/sec and 70 m3/sec. 1 JPCI7.4 Page 4 OCP will close the WHO subsectors of Kintampo (Ghana) in December 1996 and Bondoukou (C6te d'Ivoire) in June 1997. The entomological acrivities in the South Eastern extension area will be centered in Kara, the only remaining WHO sector. The total number of entomological capture points will be reduced from i50 in 1996 to 140 in 1997. The year 1997 will be the second year of the new aerial spraying contract. This is the third consecutive contract with Evergreen Helicopters Inc. ln 1997, the Programme will use slightly less helicopter hours for the eastern and western zones due to a minimal reduction in larvicide coverage (see Annex VI). Applied Research activities will continue to reduce progressively. Activities in relation to insecticides will be limited to quality control of ttre operational formulations. Collaboration with the Institut Pasteur of Paris will continue, to pursue shrdies on the different toxins of B.t. H-14. Also there will continue to be collaboration with the University of Alabama with regard to studies on the technique to identify the parasite by the heteroduplex method. Monitoring of the aquatic environment will be carried out wittrin the context of the expanded mandate of the Ecological Group, whose seventeenth session was held in Lom6 in January 1996. Following the group's decisions, the environmental studies commenced in 1995 in the main basins, as well as the results of the hydrobiological monitoring, will be consolidated, focusing on the long-term impact of using larvicides in rotation. 2.3. Planning Evaluation and Transfer Unit In 1997, the Planning Evaluation and Transfer Unit (PET) will give technical, logistic and financial support to the countries, with a view to making them technically capable of taking over the responsibility for detecting any recrudescence of onchocerciasis infection and dealing wittr it, within the framework of their national health systems. Every effort will be made to promote the process of integrating onchocerciasis control into the national health system. The Unit will support national activities involving epidemiological evaluation, ivermectin treaEnent of communities, analysis and interpretation of data and operational research. The objective is to safeguard the health improvements and economic gains which have resulted from the Onchocerciasis Control Programme. In 1996, each of the Participating Countries organized a workshop to plan among other things, for implementing community-based ivermectin treatrnent. This mode of distribution is planned for 1997 , for progressive replacement of the mobile tearns method of distribution and treatment. The PET Unit will be supporting these plans in 1997. Epi'l.emiological evaluations planned by this unit to be carried out by national tearns will be the basis on which decisions will be taken on cessation of larviciding in various basins du16g i997. a r TPCI7.4 Page 5 It is proposed to undertake ophthalmological evaluations in a number of villages in Guinea and Sierra Leone to assess the effect of ivermectin in controlling ocular morbidity and prevention of blindness. ln 1997 the unit will continue the ongoing transfer to countries of the epidemiological data collected by OCP, the training in data entry and validation, and analysis and interpretation of data. Modelling of different epidemiological situations will continue in OCP in 1997 using the ONCHOSIM model. Additional data collected from epidemiological surveillance in the initial programme area where the parasite reservoir is almost eliminated, will be used to test and validate predictions of the simulation, with particular reference to recrudescence detection, and its control with ivermectin. Training will be at the foundation of all activities. The unit will concentrate on the following disciplines : epidemiology, public health, health services management, health education, statistics and the use of computers. Training will generally be undertaken in universities and other training institutions in Africa. There will also be emphasis on training in the field and training through seminars and workshops. 2.4. Macrofil Chemotherapy Project (MACROFIL) In collaboration with the Special Programme for Research and Training in Tropical Diseases (TDR), the Macrofil Chemotherapy Project will continue clinical development of amocarzine, and preclinical development of UMFO78. Additionally, research to develop a diagnostic tool to detect ivermectin resistance in O.volwlus will continue. 2.5. Administration (ADM) The Administration and Management Support Services Units will assist the technical units to achieve the aims of the Programme. They will manage the available human, financial and other resources towards this end. The year 1997 is pivotal being at the end of Phase IV and leading into ttre phasing-out period. A medium-term (six-year) perspective will therefore be brought to bear on decisions relating to the management of resources. TPCI7.4 Page 6 3. OVERVIEW OF TIIE BI]DGET FOR 1997 3.1. General structure The Plan of Action and Budget for 1997 is presented by 'hogremme activity" (sections 4.1 to 4.7) and by "Category of expendinrre" which are the components of the Programme activities. It is strucnrred according to the revised organization chart for OCP shown at Annex 1. Table 1 presents a summary by Programme activity of the budget for each year of the fourth Financial Phase, in accordance with the organogram. Figure I is a pie-chart of the 1997 budget divided according to Programme activities. Table 2 presents a summary of the budgets by category of Expenditure for each year of the fourth Financial Phase. Figure 2 presents a pie+hart of the 1997 budget divided according to category of expenditure. Table 3 combines Tables 1 and 2 for 1997: the category of expenditure being shown for each Programme Activity. 3.2. General remarks During the preparation of the budget, the activities and the posts in the various units were reviewed to retain only those which were essentid. The budget proposed for 1997 is US$ 22,000,000 which is less than the 1996 budget and also less than that projected for 1997 in the 1996 budget document. The average costs used for the calculation of the budget are set out in Annex II. The trend in the exchange rate of the US dollar to the CFA franc for 1995 and 1996 is shown in Annex III. 3.3. Categories of expenditure fu1 sxamination of the categories of expenditure shows the various factors which have an effect on the budget level. The categories are reviewed in the order followed in Table 2. 3.3.1. Personnel services The gradual reduction in the number of staff will continue n 1997 with the abolition of 31 posts of the WHO/OCP category (Professionals and General Service staff). This represents a 19 % decrease in ttris category of staff as compared to 1996. In the overall, the personnel requirements for the whole prograrnme will diminish by 60 posts (all categories included). The continuous reduction in personnel over the period L992 to 1997 is shown in the chart below and indicates a staff reduction of 27 % over the fourth Financid Phase. It is to be noted that the Programme will continue to utilize the services of national staff, if necessary, in the original Programme area. These appear at the bottom of the figUre in the line for "Temporary National Staff" to clearly differentiate them from the permanent staff of the national teams in the western extension. f JPCI7.4 Page 7 850 1 000 900 800 700 600 500 400 300 20,0 100 s3t 1 994 o 1 995 59 69s 1 996 59 1 997 EO 1 992 National Strfl Hammizcd Stalf 1 993 Wwnopcpsar Terpor.ry ilstiml 9.(l The following definitions are offered for a better understanding of the above figure. WHO/OCP Staff Professional and General Service Staff whose salaries and allowances are paid by WHO/OCP, according to the UN salary scales. Harmonized Staff General Service Staff whose employment stanrs was changed on 1 January 1993 and whose salaries and allowances are paid by WHO/OCP, according to national public sector salary scales. SSA Staff Senior General Service Staff with nationally competitive salaries paid by WHO-OCP. National Staff The Western Extension National teams whose salaries and allowances are being paid by their respective governments. Temporary National Staff National Staff whose services are utilized on a "temporary" basis by the Programme and whose salaries and allowances are paid by their respective governments. OCP wilt pay individual lump sums to the harmonized staff as well as to the national team staff in the western extension and daily subsistence allowances to national staff in the whole Programme area when they are on duty travel. :.33O.'. JPCT7.4 Page 8 3.3.2. Consultancy services These services include consultants used by OCP, particularly for activities related to capacity building in countries, and experts who connibute to work in the fields of insecticides, entomology, hydrology, hydrobiology and cytotaxonomy; included also are the short-term professionals employed on Programme activities. The planned expenditure, of US$ 1,102,300, is less than that of 1996. 3.3.3. Operational travel Strict controls will be applied to this budget item. 3.3.4. Contracts This category covers research and service contracts signed with companies, universities and other institutions in support of specific OCP activities, €.g., aquatic monitoring, Argos teletransmission, maintenance of hydrological stations. Also included are contracts signed as part of the Macrofil Chemotherapy Project. In view of the budgetary restrictions imposed by the present economic circumstances, the planned expenditure, under this category, is less than that proposed for 1996. 3.3.5. Aerid operations The arnount estimated for aerial operations tn 1997 , is 6% less than for 1996, based on tentative proposals for cessation of larviciding in the lower Black Volta in Ghana and the Marahoue in COte d'Ivoire. 3.3.6. Operating costs These are costs which concertr the logistic needs of the Programme (vehicle fuel, spare parts) and infrastrucnrre-related services (electricity, water, telephone). Despite the increase in the costs of these services in general, the Programme should manage to reduce expenditure on this item by 267o compared to that of 1996. 3.3.7. Larvicides After careful analysis of the 1996 stocks and usage rates and the larviciding activities projected for 1997 , it is estimated that the cost of purchasing larvicides n 1997 wrll be 5% less than in 1996. 3.3.8. Supplies and Office Administration This concerns the procurement of recurrent items such as office materials, and supervision of small contracts for security, office cleaning and office equipment servicing. A budget somewhat less than that of 1996 is envisaged. JPCI7.4 Page 9 3.3.9. Statutory meetings The amount estimated under this category is identical to ttrat of the previous year and the planned activities are the same. Tight control over expenditure should make it possible to remain within ttre limits of this budget. 3.3.10. Fellowships and training This category will continue to cover current fellowships, new ones and in-service and field training, all of which are fundamental activities to increase the technical capacity of countries to take responsibility for the residual activities of onchocerciasis control. The estimated arnount, i.e., US$ 665,000, is more ttran that of the previous year. 3.3.11. National teams The governments of the Western Extension counEies have put at the disposal of the Programme, national teams to support vector control activities such as ground larviciding, and entomological evaluation. National tearns have also been put at the disposal of the Programme to carry out epidemiological evaluation, distribution of ivermectin and awareness-raising. The teams work under the technical supervision of OCP which also provides technical and fmancial support to these activities. The amount required for 1997 is less than that of 1996 despite the increased involvement of the teams in ivermectin distribution and in taking over responsibilities for onchocerciasis control in these countries. 3.4. Other categories For administative support from Geneva the amount proposed is the same as for 1996. As regards capital costs, they are higher than the 1996 estimates, because of the need to renew certain sections of the fleet, before going into the phasing-out period. 3.5. Budget summary The proposed budget requirements are sunmar'ned in tables 1 to 3 and figures 1 to 3 by "Programme Activity" and "Category of Expenditure". Specific details are given in Tables 4 to Ll for each Unit. t TPC17.4 Page 10 TABLE I BUDGET BY PROGRAMME ACTIVITY(us $) Programme Activity P fIAS E IV Proposed 1997 13.437.500 2,189,5OO ,.&95.OOO 838,OOO 2.075.OOO 475,OOO 300,ooo a5(},ooo Approved 1996 15,167,000 1,297,5@ 293,OOO 1,142,5@ 2r100,0@ 735,O00 2,198,0@ 475,000 300,0@ 570,000 Erpenditure 1995 1994 1993 E<penditure 1992 Vector control (Planning Evaluation and Transfer Unit) P E T Epidemiological Eval uation Biostatistics & lnformation Systems PET Devolution Chemotherapy Project Office of the Director Administrative & Support Services Administrative Support Geneva Statutory meetings CapitalCosts 13,496,365 1,111,450 207,16 1,006,895 1,779,421 718,5m 1 ,910,737 405,480 320,7m 658,028 15,375,150 1,047,685 't 90,151 1j77,624 1,622,235 656,831 1,842,405 451,274 238,090 548/U 16,396,227 1,608,425 196,555 1,365,354 2,658,382 585,650 2,679,531 408,45'1 238,798 366,290 21,604J72 1,626,766 235,342 1,237,O51 2,155,665 743,449 2,622,244 398,577 238,379 852,552 TOTAL 22,OOO,OOO 24,278,OOO 21,614,710 23,150,289 26,503,663 31,716,197 Note lvermectin : 5,000,000 tablets, valued at US $ 3 a tablet, will be provided free of charge by Merck and Company lnc JPCI7.4 Page 11 3 FIGURE 1 BUDGET BY PROGRAMME ACTIVITY - 1997 tB (us $) 1 Vector control 13,437,500 2 Planning Evaluation and Transfer 2,189,500 3 Administrative & Support Services 2,075,000 4 Chemotherapy Project 1,835'000 5 Capital Costs 850,000 6 ffice of the Director 838,000 7 Administrative Support Geneva 475,000 8 Statutory meetings 300,000 1 (Y") 61.00 10.00 9.40 8.30 3.90 3.80 2.20 1.40 TOTAL 22,000,000 100.00 IPCI7.4 Page 12 TABLE 2 BUDGET BY CATEGOBY OF EXPENDITURE(us $) Category of Expenditure PHASE IV Proposed 1997 Approved 1996 Expenditure 1995 E<penditure 1994 Expenditu 1993 Expenditure 1992 11,104,E34 't,337,821 823,'t01 1,926,312 6,583,449 1,964,946 4,453,435 639,160 238,379 570,337 823,2s1 39E,577 6,Oq3,OOO 1,, 651 1.627,O(X) , 471,000 300.o00 665;OOO 1,O27,7OO 475,O(x) 6,504,500 1,351,000 915,0m 2,097,0m 4,865,0@ 2,085,500 2,880,0m 555,000 300,000 550,000 1,130,O@ 475,0@ 6,014,602 1,228,6U 530,989 1,523,133 3,895,615 1,687,456 3,096,100 473,791 320,78 536,214 838rD 405,480 7,166,1@ 1,024,82. 445,2@ 1,572,610 4,856,683 1,227,58 3,888,411 318,7n 238,090 625,637 786,326 451,274 8,660,415 1,312,473 761,937 2,444,111 5,250,000 1,77E,609 3,134,898 580,2@ 23E,798 583,720 983,692 408,451 RECURRENTCOSTS Personnel Services Consultants Operational travel Contracts (Research & Others) Aerial Operations Operating Costs Larvicides Supplies Statutory Meetings Fellowships and Training National Teams Administrative Support Geneva Subtotal CAPITALCOSTS Offae Furniture Data Processing Equipment Vehicles Technical Equipment Buildings 21,r50,OOO 23,708,000 20,551,202 22,601,52s 26,137,373 30,863,645 25,OOO 50,OOO 54{),OOO 2(x).ooo 35,OOO 850,OOO 22,OOO,OOO 20,ooo 40,ooo 310,000 155,0@ 45,000 31,103 126,8U 417,589 78,627 3,882 62,086 390,609 94,467 1,602 16,925 51,829 171,580 118,054 7p02 53,277 65,751 565,988 151,570 15,966 Subtotal s70,000 658,028 548,7il 366,290 TOTAL 24,278,OOO 21,209,230 23,150,289 26,503,663 a52,552 31 ,716,197 TPCL7.4 Page 13 FIGURE 2 BUDGET BY CATEGORY OF EXPENDITURE - 1997 11 12 13 6 5 1 Personnel Services 2 Aerial Operations 3 Larvicides 4 Contracts (research & others) 5 Operating Costs 6 Consuhants 7 National Teams 8 Gapital Costs 9 Fellowships and Training 10 OperationalTravel 11 Adrninistrative Support Geneva 12 Supplies 13 Statutory Meetings (us $) 6,003,000 4,556,000 2,730,000 1,627,000 1,542,000 1,102,300 1,O27,7OO 850,000 665,000 651,000 475,000 471,000 300,000 (%) 27.30 20.70 12.40 7.40 7.00 5.00 4.60 3.90 3.00 3.00 2.20 2.10 1.40 TOTAL 22,000,000 100.00 10 8 9 1 7 4 2 3 NCfi.4 Page 14 TABLE 3 SUMMARY BY PROGRAMME ACTIVITY AND CATEGORY OF D(PEND]ruRE(us $) Activity Categoryot Expenditure Office of the Director Vector Control Planning Evaluation & Transfert Ghemo- Iherapy proiect Adminis- tration Total 1997 RECURRENTCOSTS Personnel Services Consultants Operational Travel Contracts(Research & Others) Aerial Operations Operating Costs Larvicides Supplies Statutory Meetings Fellowships and Training Natlonal Teams Administrative Support Geneva 584,000 144,O@ 55,000 30,000 25,000 300,0m 3,142,O@ 493,500 386,0m 177,000 4,556,0@ 1,152,000 2,730,000 286,000 515,O00 512,000 209,8@ 90,000 70,000 80,o00 50,000 665,000 512,7@ 285,0m 180,000 20,000 1,330,000 20,000 1,480,Om 75,000 100,000 50,ooo 280,000 90,000 475,000 2,550,OOO 5,000 10,ooo 90,000 10,ooo 6,003,OOO ,.1O2'8OO 651,OOO 11627.000 4,556,{X)O 1.542,OOO 2,730,0OO 47'l,OOO 300,ooo 6.65,OOO 1,027,704 475,OOO 21*15O*OOO 25,OOO 50.(rco 540'ooo 200.ooo 35,OOO 850,ooo 22,ooo,ooo Subtotal 1,138,OOO 13,437,500 2,189,500 1,835,0OO CAPITALCOSTS Office Furniture Data Processing Equipment Vehicles Technical Equipment Buildings 5,000 5,000 10,000 25,O00 300,000 140,0@ 35,OOO 5,000 10,ooo 150,0@ 50,000 Subtotal TOTAL 10,ooo 510,OOO 2't5,OOO o 115,OOO 1,148,OOO 13,947,500 2,404,500 1,835,OOO 2,665,O0O P E T: Planning Evaluation and Transfer unit JPCI7.4 Page 15 4. ESTIMATED COSTS BY PROGRAMME ACTTYITY 4.L. Vector Control Unit (VC[D 4.L.1. Zone-s to be treated Original Programme Area krviciding will cease on I January L997, after 22years of unintemrpted vector control on the lower Black Volta and its tributaries in Ghana. However, since certain villages in the basin still show relatively high prevalence, treatment with ivermectin has been intensified and is given four times a year. The latest epidemiological resuls recorded on the Kankelaba in February 1996, were very encouraging. Iarviciding is therefore expected to stop before the end of 1997, subject to the confirmation of these good results by a final epidemiological survey. I-arviciding in the Original area will, as from JuIy 1997, be confined to the Dienkoa basin (treated from the ground by the national team of Burkina Faso, with technical assistance from the PET Unit of OCP) and the tributaries of the Oti, Keran, Kara and M6. These basins will be treated as long as necessary and certainly beyond 1997 n the case of the Oti which had been reinvaded by infective blacKlies up to the time larviciding began in the South-eastern Extension in February 1988. Southern extension C6te d'Ivoire The latest epidemiological results recorded on the Marahoue in 1995 were very encouraging and cessation of larviciding is scheduled for the end of June 1997 subject to confirmation by a final epidemiological survey. Treament will continue n 1997 in the other basins of the Southern Extension in COte d'Ivoire (lower Comoe, lower Nzi, lower Banda:na and Sassandra). South-eastern and Westem Extensions The larviciding coverage for the basins in the South-eastern Extension will remain uasfianged n 1997.In the Western Extension, the Niger and its tributaries in the Baoako area, will continue to be treated from the ground, as in 1996, by the national tearn of Mali with technical assistance from the Vector Control Unit. In Guinea larviciding will remain the sirme as in 1996. In Sierra lrone, the sinration of insecurity has prevented aerial operations in the last tfuee ye:rs. However, depending on the results of epidemiological and entomological surveys scheduled for the first half of 1996, larviciding could be resumed later in 1996, if security conditions continue to improve. JPC17.4 Page 16 4.L.2. Larvicides The principle of rotation of the seven currently available insecticides will be maintained. In accordance with standard procedures B.t. H-14 will be used mainly in the dry season, and never for discharges above 15 m3/s., unless current research successfully produce improved formulations. ffraclofos and phoxim will be used during the transition periods when water levels are rising or the floods are subsiding. Permethrin and carbosulfan will remain the high-discharge insecticides while Abate, outside of the resistance zones, will be used without any special instructions, up todischarges 300 m3/s., if necessary. Vectron (etofenprox) will be used more in the zones of resistance to Abate and phoxim (particularly in C6te d'Ivoire), thereby reducing the pressure on the organophosphates in the discharge range of 15 to 70 m3/s. The requirements for 1997 are as follows: - Abate 24 4OOlitres (2 containers) - Phoxime 16 000 litres (2 containers) - Bt H-14 225 O00litres (18 containers) - Perm6thrine 21 000 litres (3 containers) - Carbosulfan 7 000 litres (1 container) - foraclofos 14 000 litres (1 container) - Vectron 14 000 litres (1 container) 4.L.3. Entomological evaluation network With the expected cessation of larviciding on the lower Black Volta, the subsector of Kintampo is scheduled to close down by 31 December 1996. Six months later, the subsector of Bondoukou will also close down with the planned cessation of larviciding on the Marahoue. Entomological evaluation of the Comoe basin will be carried out by the Bouake subsector. It would not be justified n 1997 to continue operating three sectors in the eastern zone overseeing only five subsectors (Hohoe, Atakpame, Kara, Bohicon and Parakou). The activities will therefore be concentrated in Kara which will be the only entomological sector in the zone. The Tamale and Parakou sectors will close down on 31 December 1996. Consequently, the number of entomological catching points to be visited regularly will be reduced from 150 in 1996 to 140 n 1997. 4.1.4. Aerial operations The year 1997 will be the second year of the new contract with Evergreen Helicopters Inc.. This is the third consecutive contract won by the company. In 1997, the helic<.r*'tg1 requirements for the Eastern and Western zones will be very slightly reduced compareo to 1996, because of the insignificant reduction in larviciding coverage. JPCI7.4 Page 17 4.1.5. Applied research In 1997 research activities will continue to reduce progressively. The equipment for insecticides efficiency testing being now fully operational, the activities in this area will be limited mainly to quality control of the operational formulations. Collaboration with the Instinrt Pasteur of Paris, will continue to pursue the study of the different toxins of B.t. H-14 with a view to elaborating new formulations. The collaboration with the University of Alabama will continue especially towards developing the heteroduplex technique for identification of the parasite. 4.1.6. Monitoring of aquatic environment The monitoring of the aquatic environment will be carried out wittrin the context of the expanded mandate of the Ecological Group. It may be noted that at its seventeenth session held in January L996 lrl.I-ome, decisions were taken to consolidate the environmental studies initiated in the main basins in 1995, as well as the results of aquatic monitoring activities focusing on the possible impact of using larvicides in rotation. Moreover, the evaluation of the long-term impact of Vectron on the non-target fauna should be continued despite the fact that it is fully operational. In the Original Programme area, monitoring will be reduced to a strict minimum and will involve the study of the potential for recolonization of the watercourses which are no longer being reated. In the extension areas, the national teams will continue the evaluation of the long+erm impact of the less selective insecticides (permethrin, carbosulfan and pyraclofos) on the non-target fauna. However, the orientation will be towards the other factors which can have an influence on the aquatic population. 4.L.7. Research contracts Contracs will be reduced to a strict minimum in line with the reduction in research activities. Except for any special studies which could be decided upon at the last moment, research contracts will be limited to those signed in 1996 with the Institut Pasteur of Paris (8.t. H-14) and the University of Alabama (DNA probes). Their costs should, however, be significantly reduced. 4.1.8. Service contracts As in previous years, service contracts will be signed with organizations working in the field of hydrology (teletransmission and maintenance of the hydrological nenvork) or that of hydrobiology (analysis of data and assistance to national teams). Cessation of larviciding on the lower Black Volta and the Marahoue will release a number of hydraulic beacons. Some will serve as spare/back-up beacons while others will be used to reinforce the existing hydrological network. OCP will therefore keep the same number of hydrologic platforms for L997, i.e., 14 PTTs and 70 beacons as back-up. JPC17.4 Page 18 4.L.9. Personnel Compared to 1996, the personnel requirements for the Vector Control Unit will decrease by 4L posts (all categories included) tn 1997, as shown in the table set out below. However, no significant change in larvicide coverage is expected in 1998, nor in the unit's staff number. However both will be markedly decreased from the end of the first year of the final phase, when larviciding ceases in the river basins of C6te d'Ivoire. 4.1.10. Consultants In response to budgetary rigour in 1996, it was possible to reduce the totality of consultancy below the budget provisions, i.e., five man-months instead of seven man- months, wittrout reducing the number of consultants. ln 1997 ttre total man-months of consultation will be four and a hdf instead of five man-months as follows : - Insecticides - DNA probes - Hydrology - Hydrobiology - cytotaxonomy 15 days 15 days 15 days 60 days 30 days 4.1.11. Budget The budget proposed for 1997 for the Vector Control Unit is US$ 13,437,500 The category I corrcsponds to the former General Sen.,'es grades I to 3 (staff harmonized). The category 2 corresponds to cori'..cts for the higher pirrd service grades 4 to 7. WHO/OCP Professionals P6-D2 P4-P5 P1-P3 STP General Service Subtotal category 1- category 2 National staff SSA TOTAL l99.il', ...i. .i.r .i:...: ,- i.::.i:56,:.:',i 65 83 110 1 10 361 :' 7_A.l+1 T1 102 131 131 383 1996 t99s 1994 1993 1992 11111 s6889 5s6s8 57674 0 260 2s9 299 290 274 223154 185 2 1 TPCI7.4 Page 19 VECTOR CONTROL UNIT(us $) (r) Chief VCU, an secondment from "lnstitut Frangais de Recherche Scientifique pour le D6v6lop;'rcment en Coopr6ration" (ORSTOM) TABLE 4 Category of Expenditure PHASE IV Proposed 1997 Approved 1996 l55.OOO 150,000 715,000 605,0m575;OOO 1,l2o,ooo 552,O{rO 1,345,000 614,000 t5,ooo 20,0o0 8.142.OOO 3,449,0@ 4935OO 386,OOO 4,556,OOO 177,OOO 5t5,OOO 1.152,OOO 2,73,0,OAO 286,OOO 521,OOO 540,000 4,865,000 382,000 600,000 1,635,000 2,880,0oo 295,OOO ,o.295.500 11,718,OO0 13,432,5OO 15,167,000 E:<penditure 1995 E<penditure 1994 E<penditure 1993 Expenditure 1992 PERSONNEL SERVICES WHO/OCP Staff Chief VCU (1) Scientists Technical Officers Administrative Assistants, Clerks, Stenographers and other @neral Service Staff Harmonized Staff Temporarv Staff SSA Subtotal 3,397,974 4,133,798 4,739,000 7,195,973 Consultants Operational Travel Aerial Operations Contracts (Research & Others) National Teams Operating Costs Larvicides Supplies 578,383 326,600 3,895,615 221,897 451,464 1,270,281 3,096,100 258,O51 477,759 295,075 4,856,683 194,627 489,938 855,348 3,888,411 183,511 506,437 517,197 5,250,000 141,'179 496,9 7 1,286,762 3,'134,898 323,777 490,724 523,O21 6,583,449 203,461 407,141 1,422,914 4,453,435 328,050 Subtotal 10,098,391 11,241,352 11,657,227 14,412J99 TOTAL 1 3,496,3C< I 15,375,150 16,396,227 21,608,172 l: JPCI7.4 Page 20 4.2. The Planning, Evaluation and Transfer (PED Unit 4.2.1 lntroduction The Planning, Evaluation and Transfer Unit (PET) is a composite unit created towards the end of 1995 with the merging of the former Epidemiological Evaluation Unit, the Unit of Biostatistics and information System and the Devolution Unit. The budget for this unit for 1996 was the result of the appropriate fusion of the budges for the three units as approved by JPC 16. The new Unit is responsible for Epidemiological Evaluation, Diagnostics and drug treatment, Biostatistics, information system and operational research, and Entomological activities as they pertain to the maintenance of residual activities in the original OCP area. ln 1997 the thrust of activities of the Unit will be focused on the direct support to the Paiticipating Countries in the transfer of the tools for diagnosis and orientation of the approach to treatment of communities, the appropriate technical skills for epidemiological evaluation and surveillance, and data management. Additionally, logistic and financial support will be provided to the countries to enable them to bener carry out these activities. Training for all categories of health staff will be continued at ttre different levels i.e. higher level training in epidemiology and other disciplines in institutions of higher learning, and on-the-job training in simple epidemiological evaluation methods in the field for middle- level staff at the District level. The unit will also train staff of the countries in simple entomological metlrods and will assist the countries in ground larviciding. The unit will also make sure that the epidemiological evaluations, patient treatment through ivermectin distribution, data analysis and interpretation, informatics and operational research are suitably adapted to the operational needs of OCP. The unit will assist and support the Participating Countries to maintain vigorous information, education and communication intervention campaigns at government and community/levels on the importance of maintaining onchocerciasis control in the countries. In collaboration with WHO/AFRO and the Participating Countries the unit will work towards the decentralization of epidemiological surveillance and/or evaluation activities. The unit will play a catalytic role in the integration of such activities into the health delivery systems of the countries. JPCI7.4 Page 2l 4.2.2 Specific action plans Epidemioloeical evaluations Specifically the unit will lend its support to the national teams in the respective counties to carry out the following evaluation activities: - evaluation of villages in the areas where interruption of larviciding is planned. The basins in question are the Kankelaba basin in Mali, the Marahoue in COte d'Ivoire and the Black Volta (Bui area) in Ghana. Following the decision to interrupt larviciding, sentinel villages will be selected in collaboration with the national teams to form part of the network of villages for surveillance activities. - evaluations will also be carried out using the national teams to assess ttre impact of combined vector control and ivermectin treatrnent on : (a) the transmission of infection, and (b) on onchocercal eye disease through follow- up ophthalmological surveys in Guinea and Sierra Leone to be carried out by consultants from the Participating Countries. The ophthalmological examinations will include photographic documentation as well as angiographic recordings where possible. - evaluation of the impact of ivermectin treatrnent in the medium tefin on the transmission of infection in the northern part of the Western Extension where this is the only means of control. - carrying out migration surveys will as in the past form part of the epidemiological evaluations/surveillance activities. Deoxyribonucleic Acid (DNA) snrdies to characterize suains of onchocerciasis using the microfilaria obtained from the epidemiological evaluations will be continued. This will be very important in determining the nature of infection still encountered in some of the "trouble spots", e.g. Bui area in the Black Volta basin in Ghana. Furthermore the Unit will continue the search for an alternative community diagnostic tool for epidemiological surveillance /evaluation. In this respect, emphasis will be placed on the validation of the DEC (Diettrylcarbamazine) Patch test and the Polymerase Chain Reaction (PCR) scratch test n 1997. 4.2.3 Distribution of ivermectin Large-scale ivermectin distribution will be continued using personnel from the Participating Countries. This will be carried out in the mapped out areas in the extension areas as well as in the specific areas in the Original Programme area. More than 11000 villages will be involved and over two million people will be treated. The unit will continue to ensure the regular monitoring of the ivermectin distribution campaigns. The evaluation of the ivermectin delivery systems in the counEies, so far carried out in seven of the Participating Countries will be continued, to include Burkina Faso, Guinea Bissau and Sierra Irone. JPCL7.4 Page 22 In 1996 each Participating Country organized a workshop to work out its plan for implementing community-based ivermectin treatnent. This mode of distribution is therefore planned for 1997 in most of the river basins in the extension zones and specific areas of the Programme to replace the mobile teams method of distribution. The national teams together with non-governmental organizations and voluntary organizations will establish this community-based treaftient. The Unit will provide support for the training needed for community-based methods of distribution. Adverse reactions to ivermectin have been minimal and minor over the years. Serious adverse reactions have not been recorded in recent years. However, monitoring and documentation of any adverse reactions to ivermectin will be continued. The volume of passive distribution remains at a minimal level. Staff at hedth centres and other health institutions responsible for this mode of treament will be encouraged through the national coordinators to mainain the simFle up+odate records of treatment given. 4.2.4. Entomological activities The PET unit will pursue a prograrnme of transferring to the countries the simple entomological activities required for control. In this respect the Unit will provide support and 6aining in ground larviciding to the countries to enable them to carry out the minimal entomological activities required in 'trouble spots" such as for example the Dienkoa and the Kulpawn basins. Additionally the Unit will reinforce through the nationals the awareness raising activities in relation to the harmlessness of the returning black flies into the area after the cessation of larviciding. 4.2.5. Data Management A priority of the Unit in 1997 will be the continuation of the 63ining of Nationals in data andysis and the interpretation of survey daa collected from the epidemiological evaluations and surveillance activities carried out by the national teams. Entry and validation programs will be tested and installed in each of the countries to render the nationals completely and independenfly operational in data management. Furthermore, the unit will continue g1g 6ansfer of the large body of accumulated epidemiological data to tlre Participating Countries. Jleining of nationals and OCP staff in the use of mappiot software, and the Global Positioning System (GPS) in the field for village locations will be provided by contracting for these services. Following this, skills in the management of the epidemiological and entomological database, using the Geographic Information System (GIS), will be transferred to the countries. For this purpose, a pool of GPS equipment will be purchased and national teams will be requested to complete the village co-ordinates during both the epidemiologicd survey and large-scale ivermectin distribution and to update the data banks. The Unit will carry out the routine analysis and interpretation of the Prograrnme's epidemiological and entomological evaluation data. This is geared to studying the medium and long-term impact of the combination of ivermectin distribution and larviciding on u'ansmission and on ocular manifestations. Data enry for such analysis will be carried o.rt by staff from the various units concerned, but temporary staff will be recruited to help when the need arises. JPCT7.4 Page 23 Supervision and coordination of the development of data banks on operational research, aerial operations administration and documentation will be continued as in the previous years. Epidemiological modelling will continue to play an important role in the interpretation of epidemiological surveillance results. The epidemiological results from the basins in the Original Programme area where larviciding has ceased will be tested and validated by comparing them with the predicted trends generated by the ONCHOSIM. The prospective evaluations of the different OCP suategies based on epidemiological modelling will be refined as and when new epidemiological results are available, particularly with regard to ivermectin distribution, monitoring and its impact on transmission. Thus, emphasis will continue to be put on the simulations of recrudescence detection and its control with ivermectin. Besides, the estimation of the other important parameters (entomological criteria, migration, etc.) of the recrudescence of onchocercal infection will be continued, taking into account observations made in the field. In this context, a contract will be signed with the Erasmus University of Rotterdam where a considerable number of simulations will be made in order to continue the validation of the model's important parameters in the light of the new epidemiological results. 4.2.6. National teams and national medical personnel of health centres As part of OCP's routine field activities concerning epidemiological evaluation, ivermectin distribution and awareness-raising, the unit will use the services of the national teams. In the eleven Participating Countries, there are national teams (central teams) each of which is composed of a coordinator and an operational (mobile) team comprising six permanent members mainly for the epidemiological evaluations. Almost all the countries have in addition, a Depury Coordinator. For the ivermectin distribution, doctors and nurses in the local health centres will be called upon to help in the supervision of large-scale treatment (by mobile teams) communiry-based and passive treaunent. As part of the effective implementation of communiry self-treatrnent, the personnel of the fixed centres at the peripheral level may be required to extend their services through planning and oufreach supervision of self-treatrnent by the populations in the areas concerned. As part of ensuring the transfer of skills and know-how for entomological activities to the countries, three staff members of the unit will train the national entomological team of Burkina Faso based in Bobo-Dioulasso. The travel allowances of the 11 workers of the national entomological team will be paid for by the unit. 4.2.7. Personnel The staff of the Planning Evaluation and Transfer Unit is set out in the table on page 24. In addition, the unit will continue to take advantage of the expertise of all the other units of the Programme. Particularly, it will use VCU administration and technical chiefs of zones, and entomological sector and subsector chiefs to successfully carry out its prograrnme for the information and awareness-raising of the local authorities and populations as well as its programme for the training of nationals and communities in ground tarviciding techniques. Staff of VCU will also be used in monitoring ivermectin treatnent. JPCI7.4 Page 24 STAFFING FOR PLANNING EVALUATION AND TRANSFER UNIT 1997 t997 t996-1992 PET EPI Professionals P4-P5 STP (short-term) General Service Subtotal Harmonized staff National Staff Temporary Nationd Staff Subtotal TOTAL I 996 I 995 1 994 1 993 1 992 1 2 8 1 2 1 J I 2 J 18 2 3 11 1 23 11 t4 15 23 28 70 70 70 70 70 s9 59 129 129 70 70 70 'iiiiiii;:;1il8ii: 140 143 85 93 98 1996-1992 : Biostatistics & Informatics 1996 t99s 1994 t993 t992 Professionals P4-P5 STP (short-term) General service TOTAL I 1 1 1 2 11 1 1 I 2 1 21 1 3 3 4 4 4 1 994 1 993 I 9921 996 1 995 2 2 1 332 2 3 1 1 5 1 1 1 J ,7 77 3 6 3 1996-1992: Devolution Professionals P4-P5 P"2-P3 STP (short-term) General service Subtotal Harmonized Staff TOTAL JPCI7.4 Page 25 4.2.8. Consultants The services of social scientists and/or primary health care experts will be used for specific studies to be conducted as part of the unit's support to operational research. Subjects for study include human migratory movements, impact of different aids on the raising of the awareness of rural communities, acceptability of diagnostic methods in the communities selected for epidemiological surveillance and follow-up of the ivermectin distribution system. The services of consultant ophthalrnologists will also be used for the detailed evaluation of the villages. The unit will also, if necessary, use temporary staff from the general service category to help in epidemiological evaluation, data entry, data processing and analysis, and temporary technicians for ophthalrnological evaluation. Twenty-nvo months of professional level consulancy and L2 months of temporary staff from the general service category, all under SSA type contracts in these different fields, have been earmarked for the unit in 1997. 4.2.9. Operational travel An amount of US$ 90,000 will be required n 1997 for the travel in the Participating Countries of professional staff under the unit's budget and the travel of national coordinators and some of their assistants mainly to Ouagadougou to review and plan specific activities with OCP. 4.2.L0. Service contracts A service contract amounting to US$ 15,000 will be signed with the Erasmus University, Rotterdam, as part of the epidemiological modelling. In addition, an amount of US$ 20,000 will be required for research on the different diagnostic tests, and an amount of US$ 5,000 will be needed to cover the cost of local contractual services for the updating of the software for the transfgl of epidemiological data to the Participzting Countries. Contracts for training on the use of the geographical information system (GIS) will require us$ 30,000. 4.2.L1. Training As mentioned above, to better t'ansfer the skills and the appropriate techniques to the countries, OCP will continue with its training policy, favouring the following disciplines: epidemiology, public health, health services management, health education, statistics and data processing. Priority will be given to epidemiological training, particularly in the health districts. flxining in all these disciplines will be provided in nro ways, either through award of fellowships to universities and training institutions in Africa or through on-the-job, in- service and field training (for example, refresher courses, ssminar5, workshops), which will be emphasized. An amount of US$ 665,000 will be required n 1997 to continue to finance fellowships already awarded, whose beneficiaries are still continuing with their studies, and to finance new fellowships and in-service raining. 4.2.L2. Budget In view of the above, the budget proposed for the p[anning, Evaluation and Transfer Unit for 1997 is US$ 2,189,500. IPCI7.4 Page 26 TABLE 5 PLANNING EVALUATION AND TRANSFER UNIT 1us $) Category of E<penditure PHASE IV Proposed Approved 1996 145,OOO 145,OOO 20.ooo l2(I,OOG 20,(XX' 62,OOO 143,0@ 143,OOO 39,000 156,000 19,500 47,500 PERSONNEL SERVICES WHO / OCP Staff Chief PET Biostatistician Clerk Laboratory Assistant Ad ministrative assistant Temporary Staff SSA Subtotal 512.OO0 548,0@ Consultants Operational Travel Operating Costs Supplies Contracts (Others) National Teams Fellowships and Training 209,800 9O,(x)O 80,ooo 5O,OOO 70,ooo sl2JOO 665.OOO 1,677,5(X' 2.189,500 450,000 160,000 1 15,500 97,OOO 85,000 530,000 Subtotal 1,437,5m TOTAL 1,985,5@ JPCI7.4 Page 27 4.3. Macrofil Chemotherapy Project (Macrofil) 4.3.1. Objectives for the Macrofil Project in 1997 The primary objective of the Macrofil Chemotherapy Project continues to be the development of safe and effective adulticidal drugs (macrofilaricides) for onchocerciasis and lymphatic filariasis. In view of the inclusion of lymphatic filariasis, additional financial support is provided by the Special Programme for Research and Training in Tropical Diseases (TDR). Phase II clinical trials of amocarzine in Ghana have shown ttrat the threeday divided dose schedule (total dose, 18mg/kg) is clinically acceptable, with no serious adverse effecs. Before the end of L996, it will also be known if this dose regimen gives good macrofilaricidal efficacy in onchocerciasis. If results are acceptable, then further clinical trials against "savanna" onchocerciasis, and "sowda" will be undertaken for registration purposes. If analysis of available amocarzine tablets in 1996 indicates that they have degraded, then manufacture and formulation of new drug supplies will be required. Preclinical studies of UMF078 continued in 1996, and if results merit it, Phase I clinical trials will be planned for 1997, and patent cover for this compound will be maintained. If good macrofilaricidal activity is shown in 1996 by any lead compound(s) tested in the O. ocheneilcattle model, then preclinical toxicology will be initiated. Work will continue on the development of a diagnostic able to detect possible resistance to ivermectin in O. volwlus at the genome level. 4.3.2. Clinical centres The Onchocerciasis Chemotherapy Research Centre (OCRC) at Hohoe Hospital, Ghana, will be retained as a pennanent clinical centre, and also will be used for in vitro chemotherapeutic studies as required. Additional clinical centres in Africa will be utilized as needed for specific additional trials of amocarzine. Estimated cosrs: US$ 310,000 4.3.3. Registration and legal costs Preparation of preclinical and clinical data for amocarzine registration, may require specific expenditure tn 1997, and patent cover will be maintained on UMF078. Estimated costs: us$ 21,000 4.3.4. Drug screening centres Atl testing of potential drugs will be carried out in animal models using Brueia pahanei and Acanthocheilonema vitae in the gerbil, B. pahanei in the dog and Onchocerca ocheflgi in caftle. Estimated costs: $ 415,000 TPCI7.4 Page 28 4.3.5. Chemical synthesis/Preclinical development. Resynthesis of amocarzine (1996-97), and any compound(s) entering preclinical development, will entail costs for large-scale synthesis by a contract company. Estimated costs: US$ 220,000 4.3.6. Strategic research A nenvork of laboratories will continue research to develop a diagnostic tool able to detect ivermectin resistance genes in O.volwlus. A "macrodiagnostics" laboratory to assist in developing macrofilaricidal action of drugs in animal and human trials will be supported through 1997. Validation of molecular targets for compound screening will continue at a low level. Estimated costs: US$ 340,000 4.3.7. Operational Travel Visits to collaborating laboratories, screening centres and companies, etc., by the Project Manager or Temporary Advisers will be carried out as needed. Estimated costs: US$ 20,000 4.3.8. Personnel Personnel requirements for the Macrofil Project remain unchanged for 1997, with one P5 professional and one G4 secretary. Total costs: us$ 285,000 4.3.9. Short-term consultants and technical advisers, meetings The Macrofil Project Steering Committee will hold two meetings in 1997, and the ad hoc Screening or Clinical Task Forces will meet when required. Participants will be paid as technical advisers. The Director, OCRC will continue to be paid as a consultant, and will attend meetings in Geneva, and elsewhere, as requested by OCT and OCP. A part-time project manager for UMF078 preclinical snrdies will be retained for approximately 95 days per annum, in the United Kingdom at a total cost of US$ 23 000. In Geneva, contributions witl be made to the office of lrgal Counsel and to the Library, for specific services to the Macrofil Project. Estimated costs: US$ 180,000 4.3.10. Budget Accordingly a budget of US$ 1,835,000 is proposed for 1997 2 22 2 2 WHO/OCP Professionals P4-P5 General service TOTAL IPCL7.4 Page 29 TABLE 6 MACROFIL CHEMOTHERAPY PROJECT(us $) Category of E:<penditure PHASE IV Proposed 1S97 Approved 1996 Expenditure 1995 Expend Expe 1994 1993 1 992 PERSONNEL SERVICES WHO/ OCP Staff Scientist Secretary r80,ooo 105,OOO 285.0OO 180,OOO 20,o00 1,3IO,OOO 20,(X)O 20,o00 1,550,O(x) 1.835,O0O 't75,0@ 105,0@ Subtotal 280,000 200,000 25,O00 1,550,000 25,O00 20,000 1,820,O@ 2,100,000 242,912 195,505 178,92E 209,373 Consultantsflemporary advisers (1 ) Operational Travel Research Contracts Supplies Cost-sharing Activity 218,69s 11,004 1,258,009 28,801 20,000 144,643 17,055 1,220,833 24,199 20,000 179,326 26,553 2,228,89t' 24,677 20,0o0 246,241 26,265 1,650,448 23,338 Subtotal 1,536,509 1,426,7@ 2,479/9 1,946,292 TOTAL 1,779,421 1,622,235 2,658,382 2,155,665 (1) Costs of meetings are included under €onsultants/Temporary advisers" JPCI7.4 Page 30 4.4. Office of the Programme Director 4.4.1. Activities The Office of the Director will be responsible for maintaining strong liaison with the statutory bodies, the Donors, the Participating Countries and the Scientific community at large. Internally, its main activities will be the management of the Programme and the implementation of general policy. This covers the co-ordination of all programme activities including research contracts and statutory meetings. In the process of setting up the new African Programme for Onchocerciasis Control (APOC), the Director General of WHO, has designated the OCP Prograrnme Director to also manage the new Programme as its Director ad interim. Because of this, 25 % of his salary will be charged to ttre APOC budget. The following activities/services will be directly tinked and charged to the Offrce of the Director - operating the Office of the Co-ordinator to assist the Director in co-ordinating Programme activities, in defining and implementation of general policy and in managing the new APOC progralnme, for which 75 % of the Co-ordinator's salary will be charged to ttre APOC budget; - operating the Documentation Center which serves an internal and an external clientele; - diffr.rsion of information and raising awareness of the various objectives of the Programme at all levels; - operating the liaison office in Geneva to facilitate the links benpeen Programme's installations and WHO Geneva; 4.4.2. Informatics Management The responsibility for the management of informatics activities has been placed in the Office of the Director. These activities are under the direct supervision of the biostatistician who will continue to centralize requests for (and specify), appropriate computer equipment, and supervise the proper use and maintenance of existing equipment. Training activities will be pursued for OCP Personnel and the national tearns of Participating Countries. Provision has been made in ttre 1997 budget for the purchase of trvo micro- computers, an AC printer for computerized cartography and peripherals. The Electronic Mail (e-mail) system is operational in the OCP headquarters and more staff will have access to it after the installation of an internal network towards the end of 1996. Provision has therefore been made for the adjunction of nenvork access cards and communication modems to the computers. JPCI7.4 Page 31 4.4.3. Personnel The restructuring of the Programme in 1996, brought certain posts from other parts of the Programme, into the office of the Director. These were the computer system Manager and the Co-ordinator, who were formerly listed respectively in ttre units of Biostatistics and Information system (BIS) and Devolution (DEVO). In 1997 they are listed under the Office of the Director. The figures in the table below take into account these movements dictated by the restnrcturing. On the other hand, the staff complement of the Office of the Director will be reduced by four fixed-term posts (one professional and three general services). The essential functions of the holders of three of these posts will be undertaken by a short-term professional and a general service staff member under a Special Services Agreement. 4.4.4. Consultants The translation of main documents will be contracted out. The services of external consultants may be needed to assist the Office of the Director in the areas of general policy and Programme management. It is to be noted that the Short-Term Professionals are budgeted under this heading which contains a total of 28 man-months n 1997. 4.4.5. Budget The budget proposed for the Office of the Programme Director for 1997 is US$ 838,000 WHO/OCP Professionals P6-D2 P5 P1-P3 STP (short-term) General Service Subtotal Personnel SSA Harmonized Staff TOTAL 1996 1995 1994 1993 1992 1 I 1 1 1 I 2 I 6 2 1 5 2 1 5 1 2 5 I 2 7 s11 9 9 2 9 11 2 2 2 ;Ii t3 11 11 1t 11 TPCI7.4 Page 32 TABLE 7 OFFICE OF THE DIRECTOR(us $) The APOC Programmc w:ll reimburse 75 percent of the salary of the Co-ordinator/Programme Manager and 25 percent .rf tire salary of the Director. Category of E:<pend itu re PHASE IV Proposed Approved 1996 Expe Expend Expenditu 1992997 1995 1994 1 993 r55,OOO 155,OOO 115,OOO 150,000 150,0@ 110,0@ 110,0@ 39,000 105,0@ 58,500 40,ooo ,o5.ooo 6,O(Xl 8,OOO 7,0O0 5E4,OOO 729,500 547,792 474,691 428,412 571,662 144,O00 55.OOO 30,qro 25,OOO 65,000 70,ooo 35,000 33,000 550,000 60,481 67,729 15,287 27,211 51,836 55,689 55,332 19,283 73,321 54,366 4,785 24,766 58,894 54,619 12,378 45,E96 254,O(X) 753,000 170,7@ 182,1Q 157,2 171,787 838.O00 1,482,500 718,500 656,831 585,650 743,449 PEBSONNEL SERVICES WHO/ OCP staff Programme Director Coordinator,Director ffice Administrative Officer lnformation fficer Administrative Assistants Secretary (Geneva) Clerk Stenographers Temporary Staff SSA Harmonized Staff Subtotal Consultants Operational Travel Operating Coss Supplies Fellowships and Training Subtotal TOTAL Note lPCt7.4 Page 33 4.5. Administration and Support Services Unit 4.5.1. Ouagadougou The Administration and Management Support Services Units in Ouagadougou will provide the necessary support for the technical units to achieve the objectives of the Programme. They will manage the available human, financial and other resources towards this end. The year 1997 is pivotal, since it is at the end of Phase [V and leads into the "phasing out". A medium-term (six-year) perspective will therefore be brought to bear on the management of resources. The Personnel Unit will see to the recruitment of staff (mostly short-term), the management of staff contracts and the orderly separation of staff from the Prograrnme. This includes the routine treatnent of medical examinations, leave, the performance evaluation system and discipline. The unit has the responsibility to see that the process of gradual staff reduction is just and equitable and ttrat the Programme retains the tecbnical competence and versatility of its remaining human resources. There will be increasing use of short-term contracts. The Supply and Services Unit will see to the procurement of goods and services including the management of contracts. It will also maintain appropriate inventories of the goods and equipment belonging to the Programme, and see to their orderly disposal in accordance with the rules. The Unit is also responsible for managing the Ouagadougou office and supporting the other offices with stationery and office equipment. In L997, the policy of rationalization by running down stocks of materials and equipment and disposing of obsolete and surplus materials, will continue. The Transport and Communications Unit wifl operate the fleet of nearly 300 vehicles in support of the field and training activities of the technical units. Vehicles bought in 1987 and before will be progressively phased out. As the Programme moves into the phasing-out period, fewer cars and station wagons will be needed. As sectors and subsectors close down, there will be fewer Toyota Hilux vehicles. In 1997, the fleet will be reduced from 309 to 275 (see paragraph 4.9. capital costs). The Unit will also maintain the existing radio communication system. The Budget and Finance Unit will manage the 1997 budget, operate 14 bank accounts, handle the payroll, make payments to suppliers of goods and services, settle staff claims, keep the books of accounts and report monthly to WHO headquarters. The Unit plans to exercise rigorous control over financial commitrnents to ensure that expenditure remains within the approved budget. 4.5.2. Geneva The Programme will continue to benefit from an adminisfrad-ze support in WHO Headquarters. This support principally takes place in the fields of Personncl administration, budget, finance, insurance, legal services and supplies. For these services, WHO is authorized to charge OCP 13% of the Progra.rnnie budget (since it is a prograrnme supported from extra-budgetary sources). This would have meant for OCP, an approximate levy of US$ 3,0U),000. However, WHO Headquarters has decided to waive this requirement in OCP's case, and charges OCP only on a cost-recovery basis. JPCL7,4 Page 34 4.5.3. Personnel The staff requirements for the administrative and managerial duties will continue to diminish progressively to follow the trend of the operational activities. The staff requirements include the four general service positions in Geneva. 4.5.4. Consultant A Short-Term Professional based in Ouagadougou, will be in charge of the Supply and Services Unit as was the case these past 4 years. 4.5.5. Budget An amount of US$ 2,550,000 is proposed for 1997, which represents a five percent decrease compared with the previous year. It may be noted that the effects of the reduction of the staff are cancelled out by the increase in the cost of personnel. 996 t99s 1994 1993 1992 !O.,ii .1r': ::: 46 50 52 8547 1 2 2 1 I 2 3 1 2 2 1 1 1 2 1 1 1 2 1 I -i-l.: t: Ei::::: A.:::::: J:::J: 52 3l 51 33 s6 58 9t 31 33 WHO/OCP Professionals P6-D2 P4-P5 P1-tTI STP (short-term) General Service Subtotal Harmonized Staff TOTAL Oijr,: 84 83 87 91 9t Onchocerciasis Control Programme in West Africa Programme de Lutte contre I'Onchocercose en Afrique de I'Ouest JOINT PROGRAMME COMMITTEE JPC - CCP COMITE CONJOINT DU PROGRAMME Office of the Chairman Bureau du Pr6sident JOINT PROGRAMME COMMTTTEE Seventeenth session Cotonou. 24 December 1996 tPCr7.4 ORIGINAL : ENGLISH November 1996 Provisional aqenda item 8 ADDENDUM 1 PLAN OF ACTION AND BUDGET 1997 Evaluation of the Fourth Financial Phase (L992-1997) Budgetary implications A proposal is before the current session of the Joint Prograrnme Committee to undertake during 1997 an evaluation of the Fourth Financial Phase (provisional agenda item 11). Should this proposal meet with the approval of the Committee its implementation would incur financial commitments estimated to be in the order of: - Phase IV Evaluation: US $ 300 000 The proposed OCP budget for 1997 (US $ 22 million) would therefore need to be increased to US $ 22 300 000.

JPC17.4 Page 35TABLE 8 ADMINISTBATION AND SUPPORT SERVICES(us $) ( Ouagadougou and Geneva ) Category of Expenditure PHASE IV Proposed 1ggit Approved 1996 Expenditu 1995 Expend 1994 115,OOO 145,000 t15,OOO 115,OOO 150,0@ 143,0@ 110,000 1 10,000 820,OO0 120,OOO 858,000 1 12,000 15,000 475,0m475.O00 1,95s.OOO 1,973,000 1,389,721 1,892,705 75.O00 too.ooo 50,OOO 280,000 90,ooo 115,000 120,000 60,000 300,0m 105,0m 63,354 61,s89 22,801 321,252 52,O20 54,7AO 41,444 22,868 255,573 25,985 595,OOO 700,0@ 521,016 401,054 2.550,OOO 2,673,000 1 ,910,737 2,293,759 Expenditu 1993 Expenditu 1992 PERSONNEL SERVICES WHO / OCP Staff Chief Administration & Management Transportation & Commu. Officer Finance Officer Personnel fficer Ad ministrative assistants,Clerks Typists & Storekeepers Harmonized Staff Temporary Staff SSA Ad ministrative Support Geneva Subtota! 2,533,866 2,353,596 Consultants Operational Travel Contracts (Others) Operating Costs Supplies 48,465 95,81E 40,064 306,059 63,710 66,817 95,E60 42,403 364,9@ 97,237 Subtotal 554,116 667,225 TOTAL 3,087,982 3,020,821 TPCI7.4 Page 36 TABLE 9 OVERVIEW OF ADMIN]STRATIVE AND DGCUNVE MANAGEMENT COSTS * (us $) Category of Expenditure PHASE IV Proposed 1997 Approved 1996 E:<penditure 1995 Expenditure 1 994 Expenditure 1993 Expenditure 1992 PERSONNEL SERVICES WHO / @P Staff Programme Director Coord inator, D irector Office Chief Administration & Management Transport & Communications Offlcer Finance & Tech. Officers Personnel Officer lnformation Officer Administrative & Technical Assistants, Clerks, Steno. Secretary (Geneva) Administrative support Geneva Harmonized Staff Tempo Staff SSA 155,OOO 155,OOO 155.OOO 145.(XX' 230.{XX) 115,OOO 860.OOO 105,OOO 475,(XX) 128.OOO 16.000 150,0@ 150,0@ 150,000 1€,Om 220,O@ 110,000 110,0@ 955,500 105,O00 475,000 119,0@ 15,000 Subtotal 2,539,(xxt 2,702,5@ 2,342,993 2,367,396 2,962,278 2,925,5s8 Consultants Operational Travel Contracts (Others) Operating Costs Supplies Fellowships and Training 229,OOO 145,000 50,o00 310,OOO 1I5,OOO 1EO,O@ 190,000 60,oo0 335,0m 138,0m 550,000 123,835 129,318 22,4O1 336,539 79,231 '106,616 97,537 22,464 310,905 45,268 121,76 150,184 40,064 310,A4 88,476 't25,411 150,479 42,403 377,2ffi 143,133 Subtotal 849,OOO 691,724 583.194 711,39 838,712 TOTAL 8.S88.OO0 2,950,590 3,673,632 3,764,270 1,45!,O00 4,155,500 3,034,717 * Summary of table 7 - Office of the Direcbr ; table I - Administration and Support Services ( Ouagaoougou and Geneva ) IPCL7.4 Page 37FIGURE 3 BUDGET BY PROGRAMME ACTIVITY - 1997 OVERVIEW ADMINISTRATIVE AND DGCUTIVE MANAGEMENT COSTS 7 4 3 1 1 Vector Control 2 Planning Evaluation and Transfer 3 Ghemotherapy Project 4 Capita! Costs (us $) 13,437,500 2,189,500 1,835,000 850,000 (/") 61.00 10.00 8.30 3.90 1.408 Statutory Meetings TOTAL 300,000 22,000,000 100.00 JPCI7.4 Page 38 4.6. Statutory meetings The meetings planned for 1997 are similar to those of the past years: the Ecological Group, the Expert Advisory Committee, three or four sessions of the Commiuee of Sponsoring Agencies, the Joint Programme Committee. The budgetary provision for these different meetings mainly covers the costs of travel and per diem, interpretation services, translation of documents, and various supplies. The costs of the participation of experts in meetings other than those mentioned above (research, ivermectin distribution, hydrology, hydrobiology, national coordinators) have been included in the "Otrlerational travel" category of the budgets of the host units. One full-time administrative officer and a secretary, budgeted for in the Office of the Director, are employed for the organization of meetings. The budget proposed for 1997 is US$ 300,000, i.e., equal to that of last year TABLE 10 STATUTORY MEMNGS(us $) 214,24 Category of E<penditure ,.PftAS E lV Approved 1996 1 995 Eqenditure 1994 Expenditure 1993 E:<penditure 1992 PERSONNEL SERVICES Temporarv Staff 30;000 35,000 35,0O0 140,0@ 110,0@ 10,000 5,000 Subtotal go,ooo 135,(xro 't25,@O 5.rloo 5,{XX) 51,926 44,464 26,677 24,135 Consultantsflemporary Advisers Operational Travel Operating Costs Contracts / Translation 113,099 154,531 1,179 93,784 95,99s 3,447 116,495 93,645 1,981 110,586 89,'103 13,672 883 Subtotal 270.(XX) '900.ooo 265,000 300,0@ 268,86 193,226 212,1z'.l. TOTAL 320,78 238,090 238,798 238,379 Propgsed; iggr.i, lPcr7.4 Page 39 4.7. Capital costs 4.7.L. Office equipment The purchase of new equipment will be strictly limited to essential items; most of the needs in office furniture will be satisfied by the redeployment of materials from closed installations. However there is need to replace some old photocopiers with faster and more versatile machines to carry the Programme for the next six years. 4.7.2. Computer equipment The purchases will be mainly focused on the effective computer tools established during the past years. There is need to establish a Local Area Nework linking the computers in the office to enable the efficient implementation of e-mail services. Installing the nenvork will also facilitate ttre introduction of WHO's new Accounting and Financial Information System (AFI). A number of machines will have to be upgraded with modems and larger memories to accommodate the current software for office work, e.g. Windows 95, and Excel. A budget of US$ 50,000 is necessary. 4.7.3. Technical equipment A small amount of scientific equipment is needed for the research laboratories and some replacements. A documentation project is being developed in conjunction with WHO Headquarters to make all the scientific and technical information now in the OCP Documentation Center, available to Participating Counfries and the scientific Community at large, on computer diskettes or CD-ROM. A scanner and nvo good printers will be required. There are also plans to refurbish the OCP region-wide radio/telerype system. Certain items of equipment will be replaced. A consolidated budget of US$ 200,000 is proposed. 4.7.4. Vehicles It is proposed to continue the gradual reduction of the fleet in 1997 n line with projections for reduction in vector conEol activities and progressive devolution to countries. The fleet will be reduced to reach an approximate level of 275 vehicles in 1997. It is necessary to remove from the fleet 93 vehicles which are already over 10 years old, replacing only 63 of them, over the two1ear period 1997-1998. This accounts for the increase in vehicle replacement cost in this final year before the start of the phasing-out period. 4.7.5. Buildings All proposals for building works will be thoroughly screened to ensure that only those which are necessary to take the Programme to ttre yeat ZNZ are approved. The amount of US$ 35,000 proposed for 1997 covers elements of 1996 projects such as the refurbishing of the Odienne compound to house the Zone West Headquarters. There is need for a hangar with a concrete floor, to store larvicides to prevent loss and deterioration, as well as paved parking for the large number of vehicles to be transferred there from Bamako. The total proposal for capital costs is US$ 850,000. NCfi.4 Page 40 TABLE 11 CAPITAL COSTS (us $) Category of Expenditure PHASE IV Proposed Approved 1996I 1995 25,OOO 20,ooo 31,103 50,o00 40,000 126,827 2@,O@ 't55,000 78,627 54O,OOO 310,000 417,58S 35,OOO 45,000 3,882 850.O00 570,000 658,028 Expenditure 1994 Expenditure 1 993 Expenditure 1992 ffice Furniture Data Processing Equipment Technical Equipment Vehicles Buildings 62,086 94,467 390,6@ 1,602 16,925 51,829 118,054 171,580 7p02 53,277 65,751 1s1,570 565,988 15,966 Tota! 548,7U 366,290 852,552 JPCI7.4 Page 4L ANNEXES I. OCP ORGANIZATION CHART il. AVERAGE COSTS USED FOR BUDGETARY CALCULATIONS M. RATES OF EXCHANGE OF THE US DOLLAR/F CFA FROM 1995 TO 1996 IV. PERSONNEL COST FROM 1992TO 1997 V. AERIAL OPERATIONS FROM T992TO 1,997 VI. MAP - PROPOSED VCU PLAN OF OPERATIONS FOR 1997 V[. MAP - VCU SECTORS, SUBSECTORS AND OPERATIONAL BASES - 1997 VI[. MAP - LARGE-SCALE TVERMECTIN TREATMENT PLAN - 1997 Ix. VEHICLES IN OPERATION FROM 1992TO 1997 42 43 44 45 46 47 48 49 50 JPCL7.4 Page 42 Annex I t6 o t - t -9t a E C E :l() oo o- o otr,5c a E o E E e6lo CL .o o a) o ?5 o5 oIE o o 6s1' o 6 @ € 1'c6 oI o I tJo o ED .s(, G G' & Eo JA o ao o o Ec Eood o .EF tU E, o o Ei(LE r( O ,rr CE IY'Fz40I r--ok i5 cEEo LrJo o oz o Er iE t d. z .( ulFa 6 J3r PE <IJc6UU a.Eo 2 EEg JI ,o(, Eo B E EEE E E !JE 2EqFa UJ! BU EEtr:, EET HEE 35YJT H 6F62t99;8rt EEEE Er- EE5 EET 832 J 6 qE 3EPt)2<!, L o utIltL o tc oFo UTE o UI . E CI ooE c 2^th =sJE< trl>Lu6 212F26<zd< rE: o o EHo5 H8 =iIETg6 E -o EE =Ttr{FC'' Eg EE oz k oG 2I F IUE- 2fr 5HElIacIJ fiE -.t cEF4 .,)ok{Foo6 o 1a tgE.ErE ,o6 9a ;HEE ir3 E5ZL =t?6 lrJ 2 1 E EIlo AVERAGE COSTS USED FOR BUDGETARY CALCULATIONS (US$) JPCI7.4 Page 43 Annex II 1996 1995 L994 Personnel Professionals - D2-P6 - P5-P4 - P3-P1 General Service Programme area Geneva Programme area Geneva 150,000 150 143,000 140 175,000 175 110,500 105 19,500 16,000 - 105,000 ,000 ,000 ,000 ,000 3,500 7,000 800 143,000 126,000 175,000 96,500 22,500 96,500 3,500 7,000 800 823 7t2 National Personnel - Consultants/month - Temporary (General Service/month) Aerial Operations Cost per flying hour (incl. fuel) - Guaranteed helicopter hours - Excess helicopter hours '4;Q0fl,1 J 7r,,gg0l 800' ,500 ,000 800 864 748 823 7t2 Insecticides Cost per litre (CIF) - B.t. H-i4 - Temephos 20 Vo EC - Permethrin20Vo EC - Carbosulfan 25Vo EC - furaclofos 50Vo EC - Phoxim - Vectron 4.64 13.94 r0.29 20.82 26.45 t7.02 24.15 4.64 t4.59 10.18 20.82 26.45 4.64 13.85 10.29 20.82 26.45 14.85 24.t5 Value of US dollar - CFA Franc - French Franc - Swiss Fra:e - Pound Sterlir,g - Deutsche Mark - Canadian Dollar - Japanese Yen :.'i --ii.:...::: :'::,jgg.'pg 'lr'..s:00 450.00 4.50 l.l4 0.62 1.37 t.36 84.00 5.80 1.43 0.67 t.67 1.38 103.00 285.00 s.68 1.47 0.60 1.68 1.18 149.00 s80.00 -O- The average cost of US$ 20,0ff) t.sed for General Service staff refers to higher-grade staff members who will maintain the OCP status. JPCI7,4 Page 44 Annex III a o- -oo lJ. ooo oo o, :, o 1() sf o rO (o o) o) (U E C(U? oolo lo OI o)\t 2[Il0kFG,f O lrrtg(+a (U o o o C o = Cf .? o- -ooII oz o- oa =? (U = (U @ @s o) @$ (o @ st lt- rO o @ ro LL o E, 5JO(ooE (@_D-io) -' O) z o trlJ o Lu o)\t (o co$ !oolo 1()9o)J o) I c(U - oo a.) o 1()(f) oo$ o 1('{' oo ro stt o r(,lo oo(o oto(o @\t o!o ot VIC=$Sn TPCL7.4 Page 45 Annex IV a t }- o) o) q(o o) @ co st (o o) o) o(Y) (Y) u?(o F- o) P oF GI o) P E*,oP,8,5tL u)fu)aLu6 =8rux(n* og8 I -E vlz E. tUL tL o Faoo o (u EE U)f o oc e E .= a oo tBy oF l+-(U Hf;F'E o E L(d .C +(LSR35 - e o o e8.(f) 8 9lo) o- .=CD= axoba 'o-6Eb?96ECI b(\tooEsgFEE :t=zz lffi tt q '@ 8t Co $!t r GO$ r(, cr) Nsl q(o $st o(f)t o a) I ooooooooooc)Oo)@f-@tosfg)Ol- o enPA z66L lo eoEluasJod (o ro ro sf TPCI7.4 Page 46 Annex V F- o) o)@ot rO lo o) CD C '= E o)x EjtrEI eo -!v'v o-oODgu) ol .cvo 9.o(f)?19 cD9ho): i; -e=o)9 EOcEEoo NF Oplffi (o o) o) (o ot c) G) o, CD\r lot+ lO cot @ I @ F- o)I oF otE6 oo =a\JA!+o U)E -)1OE l- -e lT :=ilr! o- o J E, Lu rO(o COlf NIto o,(o\f sf CO CDlrl rc) sf a t (o 6t o) a J oNa) (spuesnoq, (of-@O) tPC17.4 Page 4i Annex VI E P e 6 CD6lr or Ol a I o-o E'E €o .9o >Lhe -oE'Oc.> ehOo JJ f- o) o) tfoIL fo lUo U)zo tr tr trJ(L ob z (L I- o) O) t olL @z o tr t r,u(L o LL o z J o- l C) D t =oc c, o- u, fo C o) E o =(u F EoEc 0')oo f U' co E (I, o F 0 I tt) u E o3E EE Eo) =E Eo '"(En PE,5 € EE &o == \ = x,E 1'A E* *6 iii= I = .oto 6 . o< ai) =E ,1, E E E o,I o_ coo E(L I a+ c .9 u) EEio (l) @x. F(l) OU, F,fri5r uJd a JPCI7.4 Page 48 Annex VII ( l{J o = f- O)f- O,Cl)-9u)a5I.U Ju) [rJ 6ZJO 6fiElU tr8 lIJ .rt EU2s A I.Utu)l.)Etr=)OTU a5madg u)ox. u)9uibElUf@LuFo LU U) a a o E E E8E tL .o =FEEst'=\ c{t =.9(It 'E! =(DoEo EG,(5c.B.e9Ed-zl I (D c ceoaEcgE o{) 1pOE3CO(g\CO Ega)(l,o-o(rt u, .g?o) 93' =(ExCn O aE-EC. .ee a!s E E^ta\ () vq:s Tg@ oaD9 6-oXo)fN(/)(/) H* € E ol2E o(D = =tua c= olz E(U o_ o o ol- e €t =so oo -coI l o of oo (, l o o u)I = Ytf,a ct r \-7 Eo (U o arto E, oEo oEooE UJY :) o G) TU -o lllt- oo t6c-sOg5EE g.() --Y6q Hs f, s -9Ec c o (U{) o_ oov(! E(U(D e oo(E -otc o o o o- o C6.oo(,) =Eo.g -X5ul '4= bg Eg ag 2 r.rlY ttl{ a -I{o tU z IJJ u) (5 E -o(I, o e o =o{)Y €o : .91a =o o) =op oo v I z g. LL (5 otoJ o =o :< e e= o E c,E I q 5 I o i-:] --l i= JPCI7.4 Page 49 Annex VIII s 5 d 8 \.-_4tllJ o = z a ) a F- O) o) z I.IJ Luz trolu =E, tU J TUJ LU I o I.JJ UJ oz t(, Fz LU TUF tF tU o U) TUz oN N O) O)r z zU F l'rltrF z tr C) UJ =E,u uJ C) ct) I l.rl CIt J lJ. o U) [rJz oN o .E oo E o <! co E(lJ --C, oE oocoN o6 6) o ao E 6o c oo E (l): E UJ o o co 1! oE oltg 6 o oc -9oco! 0) ooT' o =E J -6Ec o -o c -9oc o)li uJ a a a a a a o6Eo=(EE 9E)EO EL 8'6L@CLEE=CL Pgo< I I I o E E(U CDo o- JE o =E J b(UEcfoII(L o o , Eo F 1 o U) U) a rrj =f, o e s oa rl col o u) il = Ytf,o 3oo E6 o B a H oo o_-\ o 1 o a \ JPCI7.4 Page 50 Annex IX a a a lo (\I o) o) $AI ot oo 6 oFI oo E -co E6 IL r.--::= t -:-'-ai Ii:n-l l.:-'-:.1 l.:+ l U,oEEo c o ut (6 = ffi 10 o) o) (f) o) o) (o o)(t) t o) o) $(\l @N (r) lo (D(o <,N$I \f$I ot sf ot ot @N ol to coN (r) C') ol (7)o(o o ol G) N o) P o ta C\I 9o) .!zPE =Eo.9 CE, IJ.LL uiqo6€E9k= !.u 6(L'6o= z0E @=tu l-Jo I ru ol $ OI (,, OIC"(f, a q, 6E:' olo) Gl -e& N o) o)C')(o (o tr) OI ooorooo(\I o LON oo cf) o LO cr) o(f, I oo u)