Bhutan The story of how a small mountain kingdom eliminated measles
from
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Bhutan
The story of how a small mountain kingdom eliminated measles
ISBN 978-92-9022-593-5
© World Health Organiza on 2017 Some rights reserved. This work is available under the Crea ve Commons A ribu on-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; h ps:// crea vecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no sugges on that WHO endorses any specific organiza on, products or services. The use of the WHO logo is not permi ed. If you adapt the work, then you must license your work under the same or equivalent Crea ve Commons licence. If you create a transla on of this work, you should add the following disclaimer along with the suggested cita on: “This transla on was not created by the World Health Organiza on (WHO). WHO is not responsible for the content or accuracy of this transla on. The original English edi on shall be the binding and authen c edi on”. Any media on rela ng to disputes arising under the licence shall be conducted in accordance with the media on rules of the World Intellectual Property Organiza on. Suggested cita on. Coffee table book to showcase elimina on of Measles and rubella/CRS control from Bhutan. New Delhi: World Health Organiza on, Regional Office for South-East Asia; 2017. Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publica on (CIP) data. CIP data are available at h p://apps.who.int/iris. Sales, rights and licensing. To purchase WHO publica ons, see h p://apps.who.int/bookorders. To submit requests for commercial use and queries on rights and licensing, see h p://www.who.int/about/licensing. Third-party materials. If you wish to reuse material from this work that is a ributed to a third party, such as tables, figures or images, it is your responsibility to determine whether permission is needed for that reuse and to obtain permission from the copyright holder. The risk of claims resul ng from infringement of any third-party-owned component in the work rests solely with the user. General disclaimers. The designa ons employed and the presenta on of the material in this publica on do not imply the expression of any opinion whatsoever on the part of WHO concerning the legal status of any country, territory, city or area or of its authori es, or concerning the delimita on of its fron ers or boundaries. Do ed and dashed lines on maps represent approximate border lines for which there may not yet be full agreement. The men on of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by WHO in preference to others of a similar nature that are not men oned. Errors and omissions excepted, the names of proprietary products are dis nguished by ini al capital le ers. All reasonable precau ons have been taken by WHO to verify the informa on contained in this publica on. However, the published material is being distributed without warranty of any kind, either expressed or implied. The responsibility for the interpreta on and use of the material lies with the reader. In no event shall WHO be liable for damages arising from its use. Photos: © WHO/Bhutan
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Contents Foreword Introduc on Picking up the challenge Laying the founda on Leadership Planning Infrastructure Partnerships The vaccine Let’s protect our people The vaccina on process Surveillance and verifica on Surveillance Laboratories Ge ng ready for the fes vi es Verifica on commi ee Closing the door on measles Lessons learnt Protec ng the future How can this be done? v 1 3 5 5 7 8 11 12 14 14 16 17 19 20 20 21 22 23 25
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arogyaparama labha “Health is the highest gain.” - Buddha Taking these words to heart, every day Buddhist monks chant prayers for longevity and health (ayuarogyasampatti) to bestow blessings on the people. In Bhutan, this blessing has found many manifestations, but one of the most recent has been the elimination of measles from the country.
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Foreword Bhutan has shown us that when dedicated men and women come together under commi ed leadership, they can achieve their goals, surely and convincingly. Through visionary leadership and strategic planning, the country has built a fortress against measles, far in advance of the targets set in September 2013, when Member States of the SouthEast Asia Regional Commi ee, during the Sixty-sixth Mee ng of the Commi ee, resolved to eliminate measles by 2020. Bhutan is a country that measures success through the happiness of its people. Ensuring good health is, therefore, germane to its policy. Close to four decades ago, Bhutan, in collabora on with WHO, started its programme of immuniza on, with the introduc on of MCV1 as part of the Expanded Programme on Immuniza on. As rou ne immuniza on has been strengthened and coverage expanded, the country has made remarkable gains not only in increasing the coverage of MCV1 and MCV2 to over 90% in most parts of the country but also in ensuring that surveillance and response are sharpened. Overcoming the challenges of dispersed habita ons and mountainous terrain through the enthusiasm and efforts of its well-trained and hard-working health staff, Bhutan has not seen a case of endemic measles since 2012 and in April 2017, the WHO South-East Asia Verifica on Commi ee was convinced that endemic measles has been interrupted in the Kingdom, making it one of the first two countries of the Region to achieve this success. Certainly, it is a me to celebrate and I extend my hearty congratula ons to His Royal Highness King Jigme Khesar Namgyel Wangchuck and the people of Bhutan on this remarkable achievement.
Kh lS Dr Poonam Khetrapal Singh Regional Director WHO South-East Asia Region
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Dzongkhags (districts)
Gewogs (blocks)
Population
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757 042
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In 2008, the Royal Government of Bhutan transi oned peacefully from an absolute monarchy to a democra c cons tu onal monarchy. It follows a unique policy of measuring the country’s well-being through the Gross Na onal Happiness (GNH) index – a measure of human fulfilment that informs the government’s policies. Of the nine domains of GNH, the Bhutanese are reported to have the most sa sfac on in health.
INTRODUCTION Measles – a dreadful disease. The virus hides in the air or on infected surfaces, wai ng for as long as two hours to a ack an unprotected host. Considered an almost inescapable life event in the age before vaccina on, measles, the manifesta on of infec on by the minuscule, hardy, o en deadly paramyxovirus, remained unchallenged, plaguing genera on a er genera on. When did measles first occur? We do not know for sure, but as early as the 11th century CE, Abu Bakr Mohammad ibn Zakariya al-Razi, court physician and director of a large hospital in Baghdad, described measles as a disease “more dreaded than smallpox”. When the Expanded Programme on Immuniza on (EPI) was introduced in 1979, the number of measles cases in Bhutan showed a marked decline. Measles did not, however, go away completely and in 2010 and in 2016, it resurfaced in outbreaks that affected more than 66 children and adults totally (21 in 2010 and 45 in 2016). Clearly, business as usual was not effec ve at keeping the virus at bay. What could this small, mountainous na on do? If you expected them to shrug off the challenge, read further, and you will find the story of a plucky, determined na on that came together to protect itself from a terrible scourge.
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Significant events 2016 2 outbreaks of measles and measles-mumps-rubella vaccine (MMR) introduced in routine immunization (RI)
2015 Strengthened surveillance
2013 & 2014 Zero cases of measles for two years
2012 Last endemic measles case
2010 3 outbreaks of measles
2007 Case-based measles-rubella surveillance initiated
2006 2nd dose of measlescontaining vaccine and rubella vaccine introduced in routine immunization (RI)
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1979 Launch of EPI 1st dose of measles-containing vaccine
PICKING UP THE CHALLENGE Fortresses or dzongs have been a part of Bhutanese culture for millennia, not just protec ng the people from a ack, but also serving as administra ve centres, garrisons for the army and gathering places for the celebra on of fes vi es. So, to defeat measles, Bhutan decided to build a dzong. Not a brick and mortar dzong, of course, but a fortress of immuniza on to protect the people from the onslaught of the measles virus. The leadership and administra on came together to strategize within this dzong, an army of health staff and volunteers took on the challenge of administering and opera onalizing the plan, and the en re na on came together in unity and celebra on to rid the na on of the measles virus. Before measles vaccina on was introduced in Bhutan in the year 1979, most children under the age of 15 years got measles. Treatment did not, and s ll does not, exist. Once infected, the disease took its untrammelled course, leaving its host vic m with a troublesome rash, fever, runny nose, red eyes and other such symptoms. Progress in elimina ng measles was slow, but determined efforts con nued in the ensuing decades. Between 1993 and 2002, a total of 3201 cases of measles were reported all over the country, although there were virtually no reports of other vaccine-preventable diseases. In 2000, WHO es mated that globally, 5% of all under-five deaths were caused by measles. Reducing this number was closely linked to the vision of Millennium Development Goal 4, which aimed at a two third reduc on of under-five mortality by 2015. The lead strategists of the Bhutan measles elimina on plan took this goal very seriously. As a result, Bhutan surged forward to be at the forefront of the fight against measles in the South-East Asia Region. I always ensure that vaccines are properly handled, temperature and hygiene standards are followed, and everyone is given full information about the importance of maintaining immunization coverage. A vaccinator
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LAYING THE FOUNDATION Leadership The dzong tradi onally houses the leadership and administra on, in addi on to providing a protec ve fortress for the people. In our an -measles dzong, the two arms of leadership and administra on came together to forge a strong founda on. In 2008, the Cons tu on of Bhutan, under Ar cle 9, guaranteed that “the State shall provide free access to basic public health services in both modern and tradi onal medicines”, which is delivered to its ci zens through 30 hospitals and 210 basic health units (BHUs). In May 1998, with the support of WHO, the Royal Government established the Bhutan Health Trust Fund (BHTF) to ensure sufficient finances to meet, among others, all annual expenditure on vaccines, including na onwide introduc on of measles–rubella vaccines and provision of essen al drugs as well as needles and syringes. A unique feature of the Trust is that a donor contribu on to the Fund, whether big or small, is matched by a government contribu on on a one-to-one basis. The founda on for universal health coverage in Bhutan is well established, with legal and policy mandates for universal access, the values of the Gross Na onal Happiness (GNH) concept, and strong investments in development of the health sector by the government since the early 1960s. In fact, the commitment to good health is so high that approximately 88% of health financing in Bhutan comes from the government. For the fiscal year 2016–2017, Nu. 4505.796 million was allocated for the health sector (which is about 8% of the total government expenditure). H.E. Lyonpo Tandin Wangchuk Health Minister Royal Government of Bhutan
Good health of our population is an overwhelming priority of the Royal Government of Bhutan. The health system has invested heavily in prevention. Measles elimination is an important milestone in that direction.
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Planning Protec ng a na on against disease requires mul ple layers of planning to ensure a coordinated and effec ve response. Within our
dzong, Bhutan put in place mul layered plans, ranging from wider na onal-level plans to detailed community-level plans, to ensure the successful execu on of its immuniza on programme. The Ministry of Health, under the able guidance of H.E. Lyonpo Tandin Wangchuk, has taken the lead in conver ng the en re na on into a measles-resilient dzong. Under the EPI, steps were taken to reduce morbidity and mortality from vaccine-preventable diseases, including measles. A comprehensive Mul -Year Plan (cMYP) 2014–2018 was launched to consolidate several immuniza on ac vi es. The Ministry of Health has charted effec ve strategic guidelines to ensure the effec veness of the Na onal Immuniza on Policy. Covering various aspects, including provision of quality services such as immuniza on coverage, documenta on of childhood immuniza on, iden fica on of target groups, reaching the unreached and quality assurance of immuniza on programmes (cold chain and logis cs, safety, and safe disposal of vaccina on waste), the Policy has set the bar for quality performance, right from the centre to the thromde.* Bhutan is also guided by WHO in ac ng on the Global Vaccine Ac on Plan (GVAP) and the “Strategic Plan for Measles elimina on, and Rubella and CRS Control in the South-East Asia Region”. With measles elimination, we have achieved another victory in public health in Bhutan. Dr Ugen Dophu Health Secretary Royal Government of Bhutan
*A thromde is the third level of administration, akin to a municipality.
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The strategy for elimination of endemic measles is rooted in maintaining high immunization levels in the general public and maintaining meticulous surveillance processes for detection, testing and management of reported cases. Through an active surveillance system, we are able to track every suspected case of measles, no matter where in the country it may occur. Dr. Karma Lahzeen Director Department of Public Health
Infrastructure There is a three- er system of health care in the country that comprises the three regional referral hospitals, district hospitals and the BHUs. The autonomous Jigme Dorji Wangchuck Na onal Referral Hospital is the only na onal reference hospital, with the Mongar Regional Referral Hospital and Gelephu Regional Referral Hospital being the two referral hospitals func oning under the Ministry of Health. District health offices are available in each district to look a er the domains of cura ve and preven ve health care. There are 30 hospitals, 210 BHUs and 49 sub-posts across the country. The BHUs provide primary health care and conduct outreach clinics for dispersed popula ons and those located in geographically hardto-reach areas. All district health centres, including hospitals, provide immuniza on services through immuniza on clinics. Measles and rubella surveillance are also undertaken by BHUs. At the na onal level, the EPI unit in the Department of Public Health, under the Ministry of Health, is responsible for immuniza on ac vi es. Surveillance of measles and rubella is a joint responsibility of the Vaccine-Preventable Disease (VPD) Surveillance Programme in the EPI Unit as well as the Measles, Rubella Laboratory, Royal Centre for Disease Control (RCDC), Ministry of Health. The improved laboratory at RCDC in Serbithang has greatly enhanced disease surveillance and outbreak inves ga on. To cover the cost of health-care services that are not available in the country, Nu.200 million is allocated to finance the cost of referrals to India.
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Partnerships Partnerships lie at the heart of the successful health structure in Bhutan. WHO and other UN agencies provide technical and financial support to the Ministry of Health in vaccine procurement, surveillance and other training, manual development and relevant quality improvement. The Bhutan Health Trust Fund of the Ministry of Health also provides support to the EPI programme. The district-level administra on (through district health offices) helps in the funding and implementa on of district-level programmes. Ac ve community par cipa on and empowerment in the health-care delivery system are being encouraged to facilitate the achievement of universal health coverage. There is a huge emphasis on inter- and intrasectoral collabora on and coordina on, and a need for encouragement of public–private partnerships to address health issues. Bilateral and mul lateral coopera on are always significant, not only for the resources they bring, but also because they help align the country programme with ongoing developments in the world. India provides support as the referral centre for health-care services that are not available in the country. Other important partners include WHO, UNICEF, World Bank, Japan Commi ee “Vaccines for the World’s Children”, Organiza on of the Petroleum Expor ng Countries (OPEC) and GAVI.
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The Vaccine The garrison working against measles has its roots in 1757 when Francis Home, a Sco sh physician, demonstrated that measles is caused by an infec ous agent in the blood. Nearly 200 years later, in 1954, John F. Enders and Dr Thomas C. Peebles isolated the measles virus in the blood of a 13-year-old schoolboy, David Edmonston and by 1963, the measles vaccine was licensed in the United States. In 1968, an improved measles vaccine, developed by Maurice Hilleman and his colleagues, began to be distributed. This vaccine, called the Edmonston–Enders vaccine, is usually combined with mumps and rubella and is known as the measles–mumps–rubella (MMR) vaccine.
Elimination of measles was possible due to strong commitment from our leaders, dedicated and hardworking health workers, and support from our development partners. Mr Tshewang Tamang Programme Manager VPDP
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Measles cases over the years
The vaccination process In Bhutan, the warriors of vaccine-preventable diseases were armed when the EPI was launched in 1979. One of the arrows in their quiver was measles vaccina on for children at 9 months of age. This was further sharpened when the Na onal Plan of Ac on for the Accelera on of EPI was made in 1987. In February 1988, the Sixtysixth Na onal Assembly passed a resolu on calling for all children and pregnant mothers to have access to immuniza on services and to be fully vaccinated. The health system responded effec vely and achieved universal child immuniza on (UCI) in 1991. More than 85% of the target popula on has been covered by the vaccine since 1994, with an es mate in 2000 poin ng to nearly 96% coverage. As Bhutan waged its ba le to banish measles, guidelines on measles and rubella (MR) were updated and health workers trained. In 2006, a second dose of MR vaccine was added to the EPI schedule for children aged
1998 819
2000 418
2002 2
2009 6
LET’S PROTECT OUR PEOPLE 14
24 months. In the same year, the country ran a special one- me campaign that reached out to 332 041 people in the 15–44 years age group. During the 11 days of
2016 45
2010 21
2015 11
this campaign (16–26 March), 1495 immuniza on posts achieved a coverage of over 98% of the targeted popula on. Yet, the year 2010 saw three outbreaks and 21 confirmed cases. With much effort, Bhutan managed to clamp down on the measles virus with zero cases ll 2014. But the enemy always tries to strike back – twice in 2016, outbreak situa ons were experienced in the country. The latest 2016 outbreak in the district of Trashigang (in subdistrict areas of Merak and Sakteng) had 45 cases. Clearly, more needed to be done to eliminate the virus. Measles con nued to make its presence felt, with sporadic incidents and major outbreaks reminding the health authori es that there was s ll work to be done. When the MMR vaccine replaced the MR vaccine in 2016, Bhutan was on the home stretch.
2012 1
I ensure my family is up to date on all required vaccinations. So I am proud to say, I too have helped banish measles from Bhutan. Karma Choden A proud Bhutanese parent
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SURVEILLANCE AND VERIFICATION
The WHO South-East Asia Regional Office has set the year 2020 as the measles elimina on target for the Region. Bhutan has high immuniza on coverage, an established surveillance system for mely detec on and inves ga on, and an outbreak preparedness plan. Since WHO’s defini on of elimina on of measles means zero indigenous cases in a country, how do we say that Bhutan is free of indigenous measles, given that cases were reported as recently as 2016?
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Surveillance Vaccina on can prevent a disease but surveillance detects the disease and collects ac onable informa on that helps to contain and eventually stamp it out. Surveillance efforts in Bhutan are me culous. The warriors in the health system are armed to search and scru nize every possible case of the enemy virus. Bhutan has devoted me, effort, and human and financial resources to protect its people from the clutches of measles. Surveillance is a complex ac vity. It involves detec on, no fica on and inves ga on of suspected cases using standard case defini ons; collec on, shipment and tes ng of specimens at a proficient laboratory, with mely repor ng of results; linking laboratory and surveillance data; adequate repor ng; data analysis; and taking ac on on the data. The most basic tools for surveillance are a set of uniform criteria that define the disease. These help public health officials classify and count cases consistently across repor ng areas. Bhutan has strengthened its surveillance through training of all healthcare workers at hospitals and BHUs. It has also broadened the defini on of a suspected measles case to a more sensi ve surveillance case defini on of fever and rash. Health centres no fy suspected measles cases, iden fied as “fever and rash”, to the Royal Centre for Disease Control (RCDC) under the Na onal Early Warning Alert and Response Surveillance (NEWARS) through a web-based, online informa on system (NEWARSIS), with an SMS alert to the Vaccine-Preventable Disease Surveillance Office and other relevant authori es.
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Laboratories Even a fortress needs an alarm system to ensure early warning and rapid response to
an emergency, whether it is external, like a burglary, or internal, like a fire. Laboratories sound the alarm when there is a measles outbreak. In 2016, an body tests, or serological tests, which were conducted in laboratories on 206 suspected measles cases, detected 42 posi ve cases of measles. At the same me, virology profiling is run on the blood samples, which detects the type and source of the virus. Such tes ng has great relevance to iden fy if the virus is imported or not. Molecular epidemiology analyses the unique gene c profile of the virus in an infected person. Like fingerprints, these are unique, but when the laboratory The outbreak of 2016 raised concerns about finds a pa ern that is close, it can draw linkages between the the elimination status of measles. Fortunately, cases and track its origin and movement across borders. This helps the virology results showed that this was due to surveillance track the movement of the virus from place to place. So importation of the virus and not an endemic strain. accurate is this process that the laboratory was able to confirm that Mr Sonam Wangchuk the recent outbreak in 2016 was imported and epidemiologically linked to neighbouring Chief Laboratory Officer countries, travelling across boundaries with non-vaccinated children of cow-herding families! Great care is taken to collect specimens from all suspected cases of measles, and ensure swi and safe delivery to the Na onal Measles, Rubella Laboratory at RCDC through controlled transporta on with adequate cold chain maintenance. The Na onal Measles, Rubella Laboratory was accredited by WHO in 2006, and provides facili es for inves ga on of suspected measles and rubella cases for serology and virology to the en re country. Gene c tes ng support is provided by the Regional Reference Laboratory in Thailand. RCDC
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Getting ready for the festivities No dzong can be said to have fulfilled its purpose if the people do not joyously celebrate fes vi es in its protected courtyards. But care must be taken to ensure that the celebra ons are safe and the courtyard walls high enough to prevent intrusion by unwanted pests. Bhutan worked hard to achieve the status of “no endemic measles”, but it needed an independent “security pass” cer ficate before it could celebrate this fact, secure in the knowledge that the measles virus had indeed been eliminated.
Verification Committee The Na onal Verifica on Commi ee (NVC) for Elimina on of Measles, Rubella and CRS is an independent five-member commi ee, formed on 29 September 2015. The Commi ee monitors the popula on-level immunity gaps, especially in difficult geographical loca ons, border areas, and among categories of nomad popula ons so that supplementary immuniza on ac vi es (SIAs) are accordingly conducted to plug these gaps. The NVC is assured and confident that Bhutan’s immuniza on programmes, recent improvements in and measures taken by the surveillance programme, capacity for early detec on and response to importa on of cases from neighbouring countries can keep endemic measles at bay, thus acquiring the cer fica on and status from WHO as a measles-free na on.
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Closing the door on measles And so, on 20 April 2017, the South-East Asia Regional Verifica on Commission for Measles Elimina on and Rubella/CRS Control verified that Bhutan is now free of measles. This spirited na on has shown that it is capable of reinven ng itself and finding new ways to deal with old problems. It has the ability to protect its people and take them from the high mountains and deep valleys to the forefront of development, overcoming myriad challenges – whether related to sca ered popula ons or disease.
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Lessons Learnt When quality building materials are cra ed by experts, the results are bound to be remarkable. In building the fortress of measles elimina on, leadership, planning and implementa on worked together to energize the en re na on with the common cause of figh ng the virus. Some specific learnings that emerged were as follows: Leadership invigorates a programme. The commitment and involvement of the country’s leadership brought focus to the measles elimina on effort
Today, you can breathe freely in Bhutan without fearing that the sweet mountain breeze or the warm handshake of a Bhutanese carries with it a malicious and often deadly virus.
and gave it the stature of a na onal campaign. Planning pays dividends. Detailed plans made for every level ensured that there was alignment with the na onal plan. It enabled efficient use of resources – human, financial and material – and prevented both overlap of responsibili es and “falling between the cracks”. Clarity of roles was ensured.
Coordina on is the key. In Bhutan, every arm of the system worked together in a seamless fashion. From careful and error-free surveillance at the district level to mely and sensi ve laboratory analysis, and from na onal-level campaign planning to community ac on on the ground, health workers were able to efficiently manage the elimina on process. Informa on-sharing ensures appropriate responses. No ma er how well individual components work, systems fail when they work in isola on. In Bhutan, the swi flow of informa on has been pivotal to the successful elimina on of measles in the country. In addi on, sharing of informa on across borders forms the basis of a global coordinated response that will one day lead to global eradica on of the measles virus.
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Protecting the future The measles virus survives. Hidden in the shadows, this hardy antagonist waits for the ba lements to be le unmanned to slip in and spread its malaise once more. Vigil has to be maintained to hold this ny tyrant at bay. Even when Bhutan has been declared measles-free, the high coverage of measles vaccine must be maintained, always above 95%, but the closer to 100% coverage, the be er. Hawk-eyed surveillance and con nued tes ng of suspected cases, combined with an aggressive and well-managed response to import-related cases, are crucial in preven ng the epidemic from jumping back into the country. The fortress must remain protected. Not only today, or tomorrow, but for genera ons to come.
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How can this be done? The same methods used to free Bhutan of measles must continue. Epidemiological surveillance. Rigorous repor ng on measles from every health facility in Bhutan must remain a standard prac ce. Filing the daily/weekly report under the NEWARS ensures that the virus cannot slip unseen into the system. Even a single suspected case must be reported to the RCDC for inves ga on, classifica on and follow up according to the exis ng protocols. Coordina on between surveillance and laboratory inves ga on needs to remain a priority to ensure that there is rapid informa on flow and ac on for containment of any measles occurrence. Preven on through vigilance at borders and in geographically difficult terrain. Health-care centres must remain prepared to respond readily to suspected measles cases or outbreaks, especially in labour camps and isolated pockets of low immuniza on coverage in the country iden fied by the dzongkhags. Con nued immuniza on ac vi es. Funding support for vaccina on is secured through the cMYP to be received through the annual health budget. Bhutan has not experienced any stock-outs for MR/MMR vaccines in the recent past. The Ministry of Health, together with partner organiza ons, provides regular orienta on programmes, and refresher and in-service training to health-care staff so that human resources are developed and health centres are upgraded for be er, con nued service provision. In addi on, the memory and experience of the disease drives the uptake of vaccina on. Vigilance is required by public health specialists to ensure that MR vaccina on remains a part of rou ne immuniza on and supplementary immuniza on ac vi es are carried out whenever required, not only in the near future but un l measles is completely eradicated from the face of the earth.
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Our Bhutan – We helped make it free from measles.
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World Health House Indraprastha Estate Mahatma Gandhi Marg New Delhi-110002, India www.searo.who.int