Weekly Epidemiological Record, 2010, vol. 85, 32 [full issue]

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No.32

    http://www.who.int/wer

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                                            http://www.who.int/immunization/documents/positionpapers/en/index.html.

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       

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                                                                Rhabdoviridae(Lyssavirus)       (RNA)    G                                         360–368. Knobel DL et al. Re-evaluating the burden of rabies in Africa and Asia. Bulletin of the World Health Organization, 2005, 83,  WHO Expert Consultation on Rabies: first report. Geneva, World Health Organization, 2005 (WHO Technical Report Series, 

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No. 931; available at http://whqlibdoc.who.int/trs/WHO_TRS_931_eng.pdf) 2

                                                                             

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                                 Vero                                      

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         

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Plotkin S et al. Rabies vaccines. In: Plotkin SA, Orenstein WA, Offit PA, eds. Vaccines, 5th edition, Saunders Elsevier, 2008. 4

                                                        G              FAVN   RFFIT     Warrell MJ et al. Economical multiple-site intradermal immunisation with human diploid- cell-strain vaccine is effective for 



post-exposure rabies prophylaxis. Lancet, 1985, 1059–1062.

Briggs DJ et al. Antibody response of patients after postexposure rabies vaccination with small intradermal doses of purified  chick embryo cell vaccine or purified Vero cell rabies vaccine. Bulletin of the World Health Organization, 2000, 78:693-698.

WHO Expert Commitee on Rabies, 8th report, TRS 824, WHO 1992.

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of the immunogenicity of serially diluted purified chick embryo cell rabies vaccine. Vaccine, 2005, 23:3902–3907. of a meta-analysis. Human Vaccines, 2005, 1:187–190. Vaccine, 2009, 27:7149-7155. 2004, pp. 121.

Beran J et al. Potency requirements of vaccines administered intradermally using the Thai Red Cross regimen: investigation  Sudarshan MK et al. Assessing the relationship between antigenicity and immunogenicity of human rabies vaccines. Results  Franka R et al. Rabies virus pathogenesis in relationship to intervention with inactivated and attenuated rabies vaccines.

 

WHO Expert Consultation on Rabies First Report. 2004 WHO Technical Report Series 931. Geneva Switzerland WHO,

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                                                                            WHO Expert Committee on Bilogical Strandardization. Recommendations for inactivated rabies vaccine for human use  produced in cell substrates and embryonated eggs. Annex 2, 56th meeting of the Expert Committee on Biological Standardization , October 2005. Geneva, World Health Organization, 2005 (available at http://www.who.int/biologicals/publications/trs/areas/vaccines/rabies/en/index.html). Kamoltham T et al. Rabies PrEP in children: anamnestic immune response to PCECV booster doses up to 5 years after primary vaccination. In: Proceedings of the second Rabies in Asia Conference, Hanoi, 9–11 September 2009. (Available at www.rabiesinasia.org.)



 

vaccines

Grading table I (efficacy) with key references. Conclusion: high scientific evidence that use of cell culture-derived rabies are efficacious against rabies and/or induce antibodies against rabies virus following IM or ID immunization.

Wilde H. Failures of rabies post-exposure prophylaxis. Vaccine, 2007, 25:7605–7609. 

Clinical Infectious Diseases, 2010, 50:77-79.

Shantavasinkul P et al. Failure of rabies postexposure prophylaxis in patients presenting with unusual manifestations.

long lasting immunity. Vaccine, 2006, 24:3878–3880.

Suwansrinon K et al. Survival of neutralizing antibody in previously rabies vaccinated subjects: a prospective study showing 

Gherardin AW et al. Early rabies antibody response to intramuscular booster in previously intradermally immunized travelers  using human diploid cell rabies vaccine. Journal of Travel Medicine, 2001, 8:122-126.

Horman JT et al. Antibody response after a two-year intradermal booster of rabies human diploid cell vaccine. Journal of the  American Veterinary Medical Association,1987, 191:185-187.

Brown D et al. Intradermal pre-exposure rabies vaccine elicits long lasting immunity. Vaccine, 2008, 26:3909–3912.

culture derived rabies vaccines induces 10 years of

Grading table II (duration of protection) with key references. Conclusion: Moderate scientific evidence that use of cell immunity against rabies.

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                                     http://www.who.int/vaccines-documents/DocsPDF05/815.pdf                           

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 Ajjan N et al. Comparative study of the safety and protective value, in pre-exposure use, of rabies vaccine cultivated on human diploid cells (HDCV) and of the new vaccine grown on Vero cells. Vaccine, 1989,7:125-128.

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Vaccine, 1986, 4:45-49.

Dreesen DW et al. Immune complex-like disease in 23 persons following a booster dose of rabies human diploid cell vaccine.  Fishbein DB et al. Human diploid cell rabies vaccine purified by zonal centrifugation: a controlled study of antibody

response and side effects following primary and booster pre-exposure immunizations. Vaccine, 1989, 7: 437-442. randomized, double-blind trial with purified Vero-cell rabies vaccine (PVRV). Biologicals,1998,26:299-308. Reporting System (VAERS), 1997-2005. Vaccine, 2007, 25:4244-4251. vaccines are safe.

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Lang J et al. Immunogenicity and safety in adults of a new chromatographically purified Vero-cell rabies vaccine (CPRV): a  Dobardzic A et al. Safety review of the purified chick embryo cell rabies vaccine: Data from the Vaccine Adverse Event

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Grading table III (safety) with key references. Conclusion: moderate level of scientific evidence that cell-culture based rabies  Thisyakorn U et al. Safety and immunogenicity of preexposure rabies vaccination in children infected with human

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Pappaioanou M et al. Antibody response to preexposure human diploid-cell rabies vaccine given concurrently with

                           F(ab´)2                                                                                  1989, 67 : 731-736. Wilde H et al. Purified ERIG: a safe and affordable alternative to Human RIG. Bulletin of the World Health Organization,

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                                                                                           9

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                                                                                                       10

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             F(ab')2                                 

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