Generic annual budgets for antiretroviral toxicity monitoring approaches: surveillance of antiretroviral toxicity: annexes

ANNEXES GENERIC ANNUAL BUDGETS FOR ANTIRETROVIRAL TOXICITY MONITORING APPROACHES JUNE 2020 SU RV EI LL AN CE O F AN TI RE TR OV IR AL T OX IC IT Y Annex: Generic annual budgets for antiretroviral toxicity monitoring approaches2 ANNEX: GENERIC ANNUAL BUDGETS FOR TOXICITY MONITORING APPROACHES Generic estimated budgets for implementing the toxicity surveillance approaches described in this publication are presented below. All figures should be adapted to reflect the local context and costs and adjusted to the time period. Active surveillance for specific types of toxicity within sentinel cohorts Number of sites 5 Number of people with HIV followed up 5 000–10 000 Example Total 1. Protocol development, advocacy tools and training Number of staff members per site Transport costs Per diem payment Production of reporting forms and training materials 2 000 Posters and reminder cards 1 000 Staff site training (two trainers on site times five sites times one day) 5 200 150 3 000 Subtotal 6 000 2. Recording and reporting toxicity at sites Number of staff members per site Cost per staff member per month Number of months Site coordination 1 300 12 18 000 Nurse incentives 5 100 12 6 000 Data entry and cleaning 1 150 12 9 000 Subtotal 33 000 3. Equipment and supply Laboratory supply (additional to antiretroviral therapy programme if and as needed) 11 500 Office supply 250 Printing and photocopying 250 Communication 500 Subtotal 12 500 1. GENERIC ANNUAL BUDGET (IN U.S. DOLLARS) FOR ACTIVE SURVEILLANCE FOR SPECIFIC TOXICITIES WITHIN EXISTING COHORTS Annex: Generic annual budgets for antiretroviral toxicity monitoring approaches 3 4. Monitoring and evaluation Number of staff per site Cost per staff member per month Number of months Project coordination (100%) 1 250 12 15 000 Supervision visits Note: coordinator + driver (two days per visit, US$ 100 per diem payment, four visits) 4 000 Note: fuel + four flights for remote areas (US$ 200 each) 3 000 Data management (25%) 3 000 Steering group meeting 500 Subtotal 25 500 5. Technical support Consultant (US$ 500 daily fee, US$ 200 per diem payment, eight days) and flight 8 000 Statistical support for analysis and interpretation 7 500 Subtotal 15 500 6. Report and dissemination of results Report production and dissemination 3 500 Workshop to discuss results and actions (10 national + 10 outside participants) 4 000 Subtotal 7 500 Total 100 000 Annex: Generic annual budgets for antiretroviral toxicity monitoring approaches4 2. GENERIC ANNUAL BUDGET (IN U.S. DOLLARS) FOR A PROSPECTIVE PREGNANCY EXPOSURE REGISTRY AT THE SUBNATIONAL LEVEL (HOSPITAL AND ANTENATAL CLINICS) Prospective pregnancy-exposure registry Number of sites (hospital + antenatal and delivery clinics) 2 Number of pregnant women receiving antiretroviral therapy 10 000–15 000 Example Total 1. Protocol development, advocacy tools and training Number of staff members per site Transport costs Per diem payment Production of reporting forms and training materials 6 000 Posters and reminder cards 4 000 Staff site training (two trainers on site times five sites times one day) 5 200 150 10 500 Subtotal 20 500 2. Recording and reporting toxicity at sites Number of staff members per site Cost per staff member per month Number of months Site coordination 1 350 12 8 400 Nurse incentives 12 150 12 43 200 Data entry and cleaning 2 200 12 9 600 Subtotal 61 200 3. Equipment and supply Laboratory supply (additional to the programme for preventing the mother-to-child transmission of HIV if and as needed) 15 000 Office supply 1 000 Printing and photocopying 3 000 Communication 2 000 Subtotal 21 000 4. Monitoring and evaluation Number of staff members per site Cost per staff member per month Number of months Project coordination (100%) 1 2 000 12 24 000 Supervision visits Note: coordinator + driver (two days per visit, US$ 100 per diem payment, four visits) 4 000 Note: fuel + four flights for remote areas (US$ 200 each) 3 000 Data management (25%) 1 1 000 12 12 000 Steering group meeting Note: one annual meeting 500 National working group Note: four annual meetings 300 1 200 Subtotal 44 700 Annex: Generic annual budgets for antiretroviral toxicity monitoring approaches 5 5. Technical support Consultant (US$ 500 daily fee, US$ 200 per diem payment, eight days) and flight 12 800 Statistical support for analysis and interpretation 15 000 Subtotal 27 800 6. Report and dissemination of results Report production and dissemination 10 000 Workshop to discuss results and actions (10 national + 10 outside participants) 10 000 Subtotal 20 000 Total 200 000 Annex: Generic annual budgets for antiretroviral toxicity monitoring approaches6 3. GENERIC ANNUAL BUDGET (IN U.S. DOLLARS) FOR A BIRTH DEFECTS SURVEILLANCE PROGRAMME Birth defect surveillance Number of sites 2 Sample size (births) 10 000–20 000 Example Total 1. Protocol development, advocacy tools and training Number of staff members per site Transport costs Per diem payment Production of standard operating procedures, reporting guidelines, forms and training materials 6 000 Posters and reminder cards 4 000 Staff site training (two trainers on site times two sites times three days) 10 200 150 10 500 Subtotal 20 500 2. Recording and reporting toxicity at sites Number of staff members per site Cost per staff member per month Number of months Site coordination 1 350 12 8 400 Nurse incentives 10 150 12 36 000 Data entry and cleaning 2 500 12 24 000 Subtotal 68 400 3. Equipment and supply Laboratory supply (additional to the programme to prevent the mother-to-child transmission of HIV if and as needed) 15 000 Office supply 1 000 Printing and photocopying 3 000 Communication 2 000 Subtotal 21 000 4. Monitoring and evaluation Number of staff members per site Cost per staff member per month Number of months Project coordination (100%) 1 1 250 12 15 000 Supervision visits Note: coordinator + driver (two days per visit, US$ 100 per diem payment, four visits) 4 000 Note: fuel + four flights for remote areas (US$ 200 each) 3 000 Data management (100%) 1 500 12 6 000 Steering group meeting Note: one annual meeting 500 National working group Note: four annual meetings 300 1 200 Subtotal 29 700 Annex: Generic annual budgets for antiretroviral toxicity monitoring approaches 7 5. Technical support Consultant (US$ 500 daily fee, US$ 200 per diem payment, 14 days) and flight 12 800 Statistical support for analysis and interpretation 16 800 Subtotal 29 600 6. Report and dissemination of results Report production and dissemination 10 000 Workshop to discuss results and actions (10 national + 10 outside participants) 10 000 Subtotal 20 000 Total 200 000 Annex: Generic annual budgets for antiretroviral toxicity monitoring approaches8 Prospective monitoring of cohorts of mother-infant pairs during the breastfeeding period Number of sites 1 Sample size (births) 1 000–2 000 Example Total 1. Protocol development, advocacy tools and training Number of staff members per site Transport costs Per diem payment Production of reporting forms and training materials 4 600 Posters and reminder cards 2 000 Staff site training (two trainers on site times one site times two days) 5 200 150 3 500 Subtotal 10 100 2. Recording and reporting toxicity at sites Number of staff members per site Cost per staff member per month Number of months Site coordination 1 300 12 3 600 Nurse incentives 5 100 12 6 000 Data entry and cleaning 1 150 12 1 800 Subtotal 11 400 3. Equipment and supply Laboratory supply (additional to ART programme if/as needed) 20 000 Office supply 1 000 Printing and photocopying 1 000 Communication 1 000 Subtotal 23 000 4. Monitoring and evaluation Number of staff members per site Cost per staff member per month Number of months Project coordination (100%) 1 1 250 12 15 000 Supervision visits Note: coordinator + driver (two days per visit, US$ 100 per diem payment, four visits) 4 000 Note: fuel + four flights for remote areas (US$ 200 each) 3 000 Data management (25%) 1 250 12 3 000 Steering group meeting Note: one annual meeting 500 Subtotal 25 500 4. GENERIC ANNUAL BUDGET (IN U.S. DOLLARS) FOR A PROSPECTIVE MONITORING OF COHORTS OF MOTHER–INFANT PAIRS DURING THE BREASTFEEDING PERIOD Annex: Generic annual budgets for antiretroviral toxicity monitoring approaches 9 5. Technical support Consultant (US$ 500 daily fee, US$ 200 per diem, 14 days) and flight 12 000 Statistical support for analysis and interpretation 7 500 Subtotal 19 500 6. Report and dissemination of results Report production and dissemination 5 000 Workshop to discuss results and actions (10 national + 10 outside participants) 5000 Subtotal 10 000 Total 100 000 ISBN 978-92-4-000794-9 For more information, contact: World Health Organization Department of HIV/AIDS 20, avenue Appia 1211 Geneva 27 Switzerland Email: hiv-aids@who.int www.who.int/hiv © World Health Organization 2020. Some rights reserved. This work is available under the CC BY-NC-SA 3.0 IGO licence.