More medicines for neglected and emerging infectious diseases

572 Bulletin of the World Health Organization | August 2007, 85 (8) Editorials More medicines for neglected and emerging infectious diseases Jack Radisch a a Organization for Economic Cooperation and Development, 2, rue André Pascal, Paris, France, 75016 (e-mail: jack.radisch@oecd.org). doi: 10.2471/BLT.07.045690 Countries in the Organization for Economic Cooperation and Develop- ment (OECD) account for about 80% of gross expenditure in research and development globally,1 but their col- lective health research output has not led to new medicines for many of the infectious diseases that afflict developing countries; human african trypanoso- miasis, leishmaniasis, schistosomiasis, Chagas disease, lymphatic filariasis and onchocerciasis.2 Development and delivery of medicines for such diseases face significant challenges, including cost, safety, stability, formulation and resistance. Low returns on investment combined with high developmental risks discourage business from engag- ing in this type of research. The Global Forum consistently estimates that only 10% of global health research is devoted to conditions that account for 90% of the global disease burden.3 The OECD recently held a high level forum in the Netherlands to increase international momentum on research, development and delivery of medicines, vaccines and diagnostics for neglected and emerging infectious dis- eases. This forum included government officials both from OECD and devel- oping countries and representatives from nongovernmental organizations, academia and industry. The Noordwijk Medicines Agenda describes the general consensus of this meeting surrounding problems, goals, and work that needs to be undertaken to improve the avail- ability of medicines for neglected and emerging infectious diseases.4 The Forum recognized that in addition to humanitarian reasons for fighting infectious diseases in develop- ing countries, OECD countries have a self-interest in combating infectious diseases. Pathogens can spread far from where they first developed due to increases in trade, international tourism and climate change. Severe Acute Respiratory Syndrome (SARS) exemplified how an infectious dis- ease may quickly transcend borders,5 triggering important economic ripple effects globally, even in countries with few cases.6 The Forum considered how to increase the availability of new health technologies and how to reduce the cost of doing so. Participants underscored successful advances made by Product Development Partnerships (PDPs)7 in the discovery, development and deliv- ery of medicines for neglected diseases. Many participants voiced strong sup- port for the objectives and approach of the chemical compound screening pro- cess as done by the Special Programme for Research and Training in Tropical Diseases (TDR). They pointed out the economies of scale that a virtual drug discovery network of researchers world- wide could achieve. WHO/TDR’s suc- cess suggests how cooperation through a model of open innovation8,9 might be broadened to address the major noncommunicable diseases in markets where medicines are likely to become increasingly fragmented due to genom- ics and targeted therapies. There was broad agreement on the need to garner long-term, sustainable financing for PDPs, although there was no consen- sus on which means should be used to ensure this. Participants also noted the importance of using for-profit business models, to complement PDPs, in the development of new medicines, vaccines and diagnostics for neglected diseases. Meeting the cost of scaling-up PDP investments needs to be accompanied by more accurate forecasting of demand for medicines required for neglected diseases,10 as this would reduce the risk to investors and potential innovators and could create stronger incentives to service these markets. Participants made it clear that many health issues in developing countries cannot and will not be solved by developments in health technologies alone. Nevertheless, such technologies are important and efforts are needed to create the innovation environment that will rapidly deliver new medicines for all types of disease. Participants discussed policy mech- anisms designed to spur innovation in medicines for neglected infectious dis- eases, i.e. “push” and “pull” incentives.11 The Forum articulated a coherent, cross-ministry, political message about the need for improving the avail- ability of medicines for neglected and emerging infectious diseases. OECD is considering several streams of analytical work relevant to these discussions with a view to providing a foundation for evidence-based policymaking, includ- ing: exploring the potential value of col- laborative mechanisms for intellectual property rights (IPRs), (such as patent pools or other intellectual property and data management entities); pursuing the viability of a global, virtual drug development network drawing on exist- ing initiatives (e.g. WHO/TDR and PDPs); and exploring alternative policy mechanisms to reward innovation. O References 1. OECD. Main science and technology indicators. 2006. 2. Nwaka S. and Ridley R. Virtual drug discovery and development for neglected diseases through public-private partnerships. Nature Rev Drug Discovery 2003:2. 3. Widdus, R. Public-private partnerships for health; their main targets; their diversity and their future directions. Bull World Health Organ 2001: 79; 728-734. 4. Available at: http://www.oecd.org/ dataoecd/62/11/38845838.pdf 5. Xiaoqin Fan E. SARS Economic Impacts and Implications. ERD Policy Brief, Series No. 15 May 2003. 6. Frederick R. Economic Impact of SARS, Institute of Agriculture and Natural Resources, Policy Brief Vol. 6, No. 18. 7. Moran M. A breakthrough in R&D for neglected diseases: New ways to get the drugs we need. PLoS Med 2006:2;e302. 8. Munos B. Can open-source R&D reinvigorate drug research? Nature Rev Drug Discovery 2006. 9. Nwaka S, Hudson A. Innovative lead discovery strategies for tropical diseases. Nature Rev Drug Discovery, Vol. 5 November 2006. 10. Center for Global Development, Global Health Forecasting Working Group. Saving money and improving global health through better demand forecasts. 2007. 11. Barder O, Kremer M, Levine R. Making Markets for Vaccines: Ideas to Action, Center for Global Development, 2005.