W O R L D H E A L T H ORGANIZATION ^ ORGANISATION M O N D I A L E DE YELLOW FEVER 1971 LA SANTÉ
VIR/YF/71.1 ORIGINAL: ENGLISH
EXPERT COMMITTEE ON E n t e b b e , 9-15 March
DRAFT AGENDA
A. B. C. 1. 2.
Opening by D i r e c t o r - G e n e r a l Appointment o f O f f i c e r s Administrative Previous and arrangements
or h i s
representative
p r e s e n t s t a t u s o f y e l l o w f e v e r i n the ecology
world
E p i d e m i o l o g y and 2.1 2.2 2.3 Natural
h i s t o r y of y e l l o w f e v e r i n the A m e r i c a s fever i n A f r i c a
Recent views on the n a t u r a l h i s t o r y o f y e l l o w P o s s i b l e spread of y e l l o w f e v e r t o new areas
3.
Virology 3.1 S t r u c t u r e , r e p l i c a t i o n , p h y s i c a l and chemical p r o p e r t i e s ^
4.
Immunology 4.1 4.2 A n t i b o d y responses a f t e r n a t u r a l I n f e c t i o n and Cross-reactions immunity, after vaccination
from i n f e c t i o n w i t h o t h e r Group B v i r u s e s ( i n t e r p r e t a t i o n of protection conferred by h e t e r o l o g o u s Group B
r e s u l t s i n s e r o l o g i c a l surveys, etc.)
5.
Laboratory 5.1 5.2
diagnosis single
C u r r e n t methods of d i a g n o s i s ( h i s t o p a t h o l o g y , s e r o l o g y - p a i r e d s e r a and s e r a - i s o l a t i o n and p r e l i m i n a r y i d e n t i f i c a t i o n o f v i r u s ) Recent advances i n d i a g n o s t i c methods f o r a r b o v i r u s e s and t h e i r p o s s i b l e a p p l i c a t i o n to yellow fever (immunofluorescence, gel d i f f u s i o n , e t c . ) vaccination
6.
V a c c i n e s and 6.1
17D and Dakar s t r a i n v a c c i n e s . Problems and d e s i r a b l e improvements: a d a p t i o n o f 17D v a c c i n e t o t r o p i c a l mass v a c c i n a t i o n programmes; s t u d i e s on t h e r m o s t a b i l i t y : q u a l i t y c o n t r o l ; s p e c i f i c recommendations t o t h e E x p e r t Committee on B i o l o g i c a l Standards V a c c i n a t i o n programmes i n e m e r g e n c i e s R e g u l a r v a c c i n a t i o n programmes i n " J u n g l e - y e l l o w f e v e r " a r e a s R e g u l a r v a c c i n a t i o n programmes i n " U r b a n - y e l l o w f e v e r " a r e a s control Urban a r e a s ( m a i n l y Aedes Rural areas (mainly other aegypti) species)
6.2 6.3 6.4 Vector 7.1 7.2
VIR/YF/71,1
page 2 8. Methods o f s u r v e i l l a n c e f o r y e l l o w 8.1 8.2 Early recognition fever
of suspected cases number
Conduct o f s e r o l o g i c a l s u r v e y s i n human b e i n g s (mode o f s a m p l i n g s e r a , required, m u l t i p u r p o s e s e r a , a r e a s and groups o f p r i o r i t y , e t c . ) studies i n w i l d and s e n t i n e l reservoirs animals
8.3 8.4 8.5 9. 10.
Serological
V i r u s c i r c u l a t i o n i n animal Vector surveillance
F u r t h e r r e s e a r c h and i n v e s t i g a t i o n C o n c l u s i o n s and recommendations