The Accelerating Access Initiative: experience with a multinational workplace programme in Africa

794 Bull World Health Organ 2009;87:794–798 | doi:10.2471/BLT.08.052027 Lessons from the field The Accelerating Access Initiative: experience with a multinational workplace programme in Africa S Van der Borght,a V Janssens,b MF Schim van der Loeff,c A Kajemba,c H Rijckborst,a JMA Langeb & TF Rinke de Wit b Problem A multinational company with operations in several African countries was committed to offer antiretroviral treatment to its employees and their dependants. Approach The Accelerating Access Initiative (AAI), an initiative of six pharmaceutical companies and five United Nations’ agencies, offered the possibility of obtaining brand antiretroviral drugs (ARVs) at 10% of the commercial price. PharmAccess, a foundation aimed at removing barriers to AIDS treatment in Africa, helped to establish an HIV policy and treatment guidelines, and a workplace programme was rolled out from September 2001. Local setting Private sector employers in Africa are keen to take more responsibility in HIV prevention and AIDS care. An important hurdle for African employers remains the price and availability of ARVs. Relevant changes The programme encountered various hurdles, among them the need for multiple contracts with multiple companies, complex importation procedures, taxes levied on ARVs, lack of support from pharmaceutical companies in importation and transportation, slow delivery of the drugs, lack of institutional memory in pharmaceutical companies and government policies excluding the company from access to ARVs under the AAI. Lessons learned The launch of the AAI enabled this multinational company to offer access to ARVs to its employees and dependants. The private sector should have access to these discounted drugs under the AAI. A network of local AAI offices should be created to assist in logistics of drugs ordering, purchase and clearance. No taxes should be levied on ARVs. Une traduction en français de ce résumé figure à la fin de l’article. Al final del artículo se facilita una traducción al español. .ةلاقلما هذهل لماكلا صنلا ةياهن في ةصلاخلا هذهل ةيبرعلا ةمجترلا a Heineken International Health Affairs, Tweede Weteringplantsoen 21, 1017 ZD Amsterdam, Netherlands. b PharmAccess Foundation, Amsterdam, Netherlands. c GGD (Public health service), Amsterdam, Netherlands. d Bralima SARL, Kinshasa, Democratic Republic of the Congo. Correspondence to S Van der Borght (e-mail: Stefaan.vanderBorght@heineken.com). (Submitted: 16 April 2008 – Revised version received: 9 January 2009 – Accepted: 28 January 2009 – Published online: 20 August 2009 ) Problem HIV is the largest threat to adult survival in sub-Saharan Africa. According to UNAIDS, 33 million people were living with HIV by December 2007, of whom 22 million were in sub-Saharan Africa. In 2007 an estimated 1.5 million sub- Saharan Africans died of AIDS and an estimated 1.9 million became infected with HIV.1 Several international initiatives were launched to increase funding for antiretroviral therapy. This has led to a spectacular increase in access to antiretroviral drugs (ARVs) in Africa: by April 2007 an estimated 28% of eligible HIV patients in sub-Saharan Africa were on ARVs.2 One initiative that aimed to increase access was the Accel- erating Access Initiative (AAI). This paper reports practical experiences of a multinational company with the AAI. Approach In May 2000 five United Nations organizations – United Na- tions Population Fund (UNFPA), United Nations Children’s Fund (UNICEF), WHO, The World Bank and the Joint United Nations Programme on HIV/AIDS (UNAIDS) – an- nounced a partnership with five pharmaceutical companies to address the lack of affordable HIV medicines in resource- poor settings.3 This partnership, the AAI,4 was committed to offer ARVs at about 10% of the commercial price to the public sector and nongovernmental organizations that complied with three conditions (correct use, no mark-up, no backflow of drugs to markets in developed countries). By September 2006, an estimated 424 000 Africans were treated with ARVs provided through AAI arrangements,5 most of them in public sector treatment programmes. In July 2001, multinational brewing company Heineken International, with headquarters in the Netherlands and operating companies (OPCOs) in several African countries, decided to include ART among the medical benefits for em- ployees and their dependants, including children. The com- pany, itself selling a brand beer, preferred to purchase brand ARVs, and accepted that this would make the programme more expensive. The AAI price reductions made the provi- sion of ARVs to employees and dependants affordable for the company. A partnership was established with PharmAccess, a foundation specialized in removing barriers to AIDS treat- ment in Africa. PharmAccess conducted assessments, provided training, helped define treatment protocols, provided laboratory sup- port, established a web-based database for patient follow-up6 and conducted monitoring, evaluation and quality control. PharmAccess interacted with AAI to guarantee a continuous availability of ARVs at the OPCOs. The programme was gradually rolled out at 14 OPCOs in 6 countries: Burundi, the Congo, the Democratic Republic of the Congo, Nigeria, Rwanda and Sierra Leone. The average size of the workforce 795Bull World Health Organ 2009;87:794–798 | doi:10.2471/BLT.08.052027 Lessons from the field Access to antiretrovirals in the private sector in AfricaS Van der Borght et al. per OPCO varied between 200 and 500 employees; including spouses and children, the total target population was ± 30 000 of which 10 332 were adults (Table 1). Through the company’s voluntary counselling and testing pro- gramme, 531 infections were diagnosed among employees and dependants, and 273 HIV patients had started highly active ARV therapy (HAART) by mid- 2008. PharmAccess arranged purchase and shipment of ARVs and the OPCOs organized customs clearance and stor- age. The chosen first and second line regimens implied procurement of eight drugs from six different pharmaceuti- cal companies. PharmAccess signed agreements with these six companies. Because neither the pharmaceutical companies nor PharmAccess had local offices in most of the six countries, the local OPCO had to clear the goods at customs. If the products were not yet registered in the country, the OPCO had to arrange temporary import per- mits. In the rare cases that a pharma- ceutical company had a local office, this did not assist in ordering and receiving drugs for the company. It was difficult to import newer ARVs as they were usually not registered. Challenges After some time it became possible in some countries to purchase ARVs (both generic and brand) locally. If the drugs were prequalified by WHO, the OPCOs obtained ARVs locally through government agencies. The Ministry of Health in one country felt that drugs Table 1. Test results and treatment uptake in six sub-Saharan African countries in the workplace programme of a multinational company, 2001–2008 Countries with operating companies with operational HIV workplace programme Adult target population as of 1 January 2008 Number of HIV tests done in adultsa Number of HIV infections diagnosed Male/female ratio of HIV diagnoses Cumulative number of patients who started ARV therapy as of 25 July 2008 Male/female ratio of patients on ARV therapy Burundi 1 059 1 283 77 1.40 57 1.38 Congo 1 214 980 68 1.61 38 1.85 Democratic Republic of the Congo 3 040 3 828 64 1.06 28 1.42 Nigeria 3 889 5 605 154 1.33 77 1.19 Rwanda 1 000 949 115 1.74 73 1.25 Sierra Leone 130 64 4 only male 0 0 Total 10 332 12 709 482 1.45 273 1.34 ARV, antiretroviral a Some people might have been tested more than once. Due to turnover of the workforce, it cannot be calculated which proportion of the current workforce has been tested. purchased with a grant from the Global Fund to fight AIDS, Tuberculosis and Malaria should not be re-sold, so it stopped the provision of drugs to the OPCO. The same government declined to provide free ARVs to the OPCO, ar- guing that a for-profit private company should not have access to free drugs. Given these challenges, the company sometimes purchased generic ARVs. Generic drug companies were generally more helpful than brand pharmaceuti- cal companies in the importation of products through their local representa- tives. For newer drugs, the AAI was the only source of supply. Procuring ARVs was complex. Several pharmaceutical companies had not yet developed AAI-agreement documents and practicalities differed from one to another. Sometimes a pharmaceutical company insisted that PharmAccess should sign one agree- ment per country rather than one gen- eral agreement covering all sub-Saharan countries. The high turnover of staff in the pharmaceutical companies af- fected institutional memory; at times PharmAccess had to explain AAI pro- cedures to new staff at pharmaceutical companies. The price discount that was ob- tained was different per product and per company and varied between 77% and 93%. The door-to-door delivery time of small ARV orders varied between 1 and 5 months. Despite the explicit as- surance that pharmaceutical companies would carry transport costs of ARVs, this was not always the case in practice. Surprisingly none of the pharmaceutical companies ever requested PharmAccess to provide evidence of drug flows or absence of mark-up. Lessons learned The AAI was set up as a public sector, country-led process.7 This implied that the private sector in most African coun- tries could not benefit from the AAI. We argue that allowing the African private sector employers, private clinics and private health insurance compa- nies to obtain ARVs through AAI will contribute to more sustainable access for all patients in sub-Saharan Africa.8 Private sector employers in Africa are keen to take more responsibility in HIV prevention and AIDS care.9 An important hurdle for African employ- ers remains the price of ARVs; allowing them access to ARVs under the AAI would make a big difference. The over- stretched African public health care sector would indirectly benefit from this, allowing increased access for the poor. The second sector that would ben- efit from AAI support is the private health care sector. Private clinics in Africa provide care to a substantial and increasing part of the population.10 Na- tional governments should allow these clinics to use ARVs obtained through AAI. The quality of the performance of these clinics should be assessed and monitoring is needed regarding mark- ups on drugs; all private clinics provid- ing ARVs should comply with national treatment standards.11 The third entity requiring access to AAI is the private health insurance sec- tor in Africa. Private health insurance 796 Bull World Health Organ 2009;87:794–798 | doi:10.2471/BLT.08.052027 Lessons from the field Access to antiretrovirals in the private sector in Africa S Van der Borght et al. is uncommon in most of sub-Saharan Africa but this situation is changing in several countries.12 Health insurance and managed care may be instrumental in making African health care more self-supporting and less dependent on external donors. Therefore, African health maintenance organizations and health insurance companies should be given access to AAI-discounted ARVs. The launch of the AAI in the year 2000 enabled this multinational to provide ARV therapy to its employees, their spouses and children in Africa. The company’s experience with the AAI indicates the need for local AAI of- fices in African countries. Such offices could facilitate ordering, clearance and channel bulk-procurement of ARVs for the three private sector actors named previously. Registration of drugs is often prob- lematic, importation is highly complex and taxes are being levied on ARVs. These issues should be addressed by African governments. The lessons learned are summarized in Box 1. Recommendations The AAI has led to substantial price reductions of brand drugs and increased Box 1. Lessons learned • The private sector should have access to discounted ARVs under the AAI. • A network of local AAI offices should be created to assist in logistics of drugs ordering, purchase and clearance. • No taxes should be levied on ARVs. AAI, Accelerated Access Initiative; ARV, antiretroviral drugs. access to ARVs. Administrative, logisti- cal and regulatory hurdles have meant that the full potential of the AAI has not been fulfilled. The following four rec- ommendations are made to strengthen the AAI and increase access to afford- able good quality drugs in sub-Saharan Africa. (i) AAI eligibility should be ex- tended beyond the public sector. Local private clinics, health insurers and health maintenance organizations should get access to AAI ARVs, under specific con- ditions. (ii) Governments should waive taxes on ARVs, simplify and harmonize the drug registration process and certify private clinicians. (iii) Private companies and non-profit organizations that wish to provide ART to their employees and dependants should be encouraged to do so and should benefit from AAI. (iv) The pharmaceutical companies within AAI should support the creation of a network of local AAI distributors of ARVs. International donor funds should invest in this network. ■ Acknowledgements JMA Lange & TF Rinke de Wit are also affiliated with the Center for Poverty-related Communicable Dis- eases (CPCD), Academic Medical Cen- ter (AMC), University of Amsterdam, Meibergdreef 9, 1100 DE Amsterdam, the Netherlands. The pharmaceutical companies in the AAI were, initially, Boehringer-Ingelheim, Bristol Myers Squibb, GlaxoSmithKine, Merck&Co and F Hoffman-LaRoche. Abbott Laboratories joined in 2001 and Gilead Sciences in 2004. Funding: The Workplace programme is funded by Heineken International. Competing interests: None declared. Résumé Initiative Accélérer l'Accès : expérience acquise avec un programme de délivrance des ARV au poste de travail, mené par une multinationale en Afrique Problématique Une entreprise multinationale opérant dans plusieurs pays africains s'est engagée à proposer un traitement antirétroviral à ses employés et à leurs dépendants. Démarche L'Initiative Accélérer l'Accès (IAA), impliquant six entreprises pharmaceutiques et cinq agences des Nations Unies, offre la possibilité d'acquérir des antirétroviraux (ARV) de marque à un dixième de leur prix dans le commerce. PharmAcces, une fondation visant à éliminer les obstacles au traitement du sida en Afrique, a aidé à mettre en place une politique contre le VIH, ainsi que des recommandations thérapeutiques, et un programme de lutte contre cette maladie au poste de travail a été mis en route en septembre 2001. Contexte local En Afrique, les employeurs du secteur privé souhaiteraient prendre plus de responsabilités dans la prévention du VIH et la prestation de soins concernant le sida. Le prix et le manque de disponibilité des ARV restent un obstacle important dans cette voie. Modifications pertinentes Le programme s'est heurté à diverses difficultés, dont la nécessité de passer de multiples contrats avec un grand nombre d'entreprises, la complexité des procédures d'importation, les taxes prélevées sur les ARV, le manque de soutien des entreprises pharmaceutiques pour l'importation et le transport de ces médicaments, la lenteur de leur livraison, le manque de mémoire institutionnelle de l'industrie pharmaceutique et les politiques gouvernementales interdisant aux entreprises d'accéder aux ARV par le biais de l'IAA. Enseignements tirés Le lancement de l'IAA a permis à cette entreprise multinationale de proposer un accès aux ARV à ses employés et à leurs dépendants. Le secteur privé devrait avoir accès à des ARV à prix réduit dans le cadre de l'IAA. Il faudrait aussi créer un réseau de bureaux locaux de l'IAA pour apporter une assistance logistique dans la commande, l'acquisition et l'autorisation de ces médicaments. Aucune taxe ne devrait être prélevée sur les ARV. 797Bull World Health Organ 2009;87:794–798 | doi:10.2471/BLT.08.052027 Lessons from the field Access to antiretrovirals in the private sector in AfricaS Van der Borght et al. Resumen Iniciativa para Acelerar el Acceso: experiencia de un programa en los centros de trabajo de una multinacional en África Problema Una multinacional que operaba en varios países africanos se comprometió a ofrecer tratamiento antirretroviral a sus empleados y a sus familiares a cargo. Enfoque La Iniciativa para Acelerar el Acceso (IAA), en la que participan seis empresas farmacéuticas y cinco organismos de las Naciones Unidas, ofreció la posibilidad de obtener antirretrovirales (ARV) comerciales a un 10% del precio habitual. PharmAccess, una fundación cuyo objetivo es eliminar las barreras al tratamiento del sida en África, ayudó a establecer una política y directrices terapéuticas para la infección por VIH, y a partir de septiembre de 2001 se puso en marcha un programa para los centros de trabajo. Contexto local Los empleadores del sector privado de África tienen gran interés en asumir más responsabilidad en la prevención de la infección por VIH y la atención a los enfermos de sida, pero el precio y la disponibilidad de ARV siguen siendo obstáculos importantes para ellos. Cambios destacables El programa tropezó con diversos obstáculos, entre ellos la necesidad de múltiples contratos con diversas empresas, unos procedimientos de importación complejos, los impuestos que gravaban los antirretrovirales, la falta de apoyo de las empresas farmacéuticas para la importación y el transporte, la lentitud del suministro de los medicamentos, la falta de memoria institucional en las compañías farmacéuticas, y las políticas gubernamentales que impedían a la empresa acceder a los antirretrovirales en el marco de la IAA. Enseñanzas extraídas El lanzamiento de la IAA permitió a esta multinacional ofrecer acceso a los ARV a sus empleados y sus familiares a cargo. El sector privado debería tener acceso a esos medicamentos con descuento en el marco de la IAA. Se debería crear una red de oficinas locales de IAA que facilitaran la logística de los pedidos, la autorización y la compra de los medicamentos. Por último, los ARV no deberían estar sujetos a impuestos. 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Geneva: Initiative on Public-Private Partnerships for Health; 2004. صخلم ايقيرفأ في تايسنجلا ددعتلما لمعلا نكامأ جمانبرل ةبستكلما ةبرخلا :ةَّلجعلما ةحاتلإا ةردابم تايلمع اهل يتلا تايسنجلا ةددعتلما تاكشرلا ىدحإ تمزتلا :ةلكشلما تاسويرفلل ةداضلما ةيودلأاب ةجلاعلما ميدقتب ةددعتم ةيقيرفأ نادلب في .مهنوليعي نلمو اهيفظولم ةيرقهقلا تاكشر تس اهيف تكراش ةردابم يه ةل َّجعلما ةحاتلإا ةردابم نإ :بولسلأا لىع لوصحلا ةيناكمإ ميدقتل ،ةدحتلما مملأل ةعبات تلااكو سمخ عم ةيئاود ةيرقهقلا تاسويرفلل ةداضلما )ةيكللما ةلجسلما( يراجتلا مسلاا تاذ ةيودلأا يتلا سسكأ مراف ةسسؤم تدعاس دقو .يراجتلا اهرعس نم %10 ءاقل لىع ،ايقيرفأ في زديلإا ةجلاعم لىع لوصحلا مامأ قئاوعلا ةلازإ لىإ فدهت لمعلا نكاملأ جماربو ةجلاعملل ةيداشرإ لئلاد عضوو تاسايس سيسأت .2001 برمتبس/لوليأ نم ًاءدب اهذيفنتل نم ديزلما لمحل ايقيرفأ في صاخلا عاطقلا وفظوم صرحي :ليحلما عقولما رفاوتو رعس ىقبيو .هاضرم ةياعرو زديلإا سويرف نم ةياقولا نع تايلوؤسلما .مهمامأ ةيربك ةبقع ةيرقهقلا تاسويرفلل ةداضلما ةيودلأا لىإ ةجاحلا اهنيب نم ،ةفلتخم تابقع جمانبرلا هجاوي :ةلصلا تاذ تايرغتلا ،دايرتسلال ةدقعلما تاءارجلإاو ،ةديدع تاكشر عم ةديدع لاصتا طاقن دوجو نادقفو ،ةيرقهقلا تاسويرفلل ةداضلما ةيودلأا لىع ةضورفلما بئاضرلاو ،ةيودلأا ليصوت ءطبو ،ةيودلأا لقنو دايرتسا في ةيودلأا تاكشر نم معدلا يتلا ةيموكحلا تاسايسلاو ،ةيودلأا تاكشر في ةيسسؤلما ةركاذلا نادقفو تحت ةيرقهقلا تاسويرفلل ةداضلما ةيودلأا لىع لوصحلا نم ةكشرلا دعبتست .ةل َّجعلما ةحاتلإا ةردابم ةلظم ةكشرلا هذه ينكتم لىإ ةل َّجعلما ةحاتلإا ةردابم قلاطإ ىدأ :ةدافتسلما سوردلا ةيرقهقلا تاسويرفلل ةداضلما ةيودلأا ةحاتإ ميدقت نم تايسنجلا ةددعتلما لىإ لوصولا صاخلا عاطقلل حاتي نأ دبلاو .مهنوليعي نم لىإو اهيفظوم لىإ .ةلجعلما ةحاتلإا ةردابم ةلظم تحت تاضيفختلا نم ةديفتسلما ةيودلأا هذه في ةدعاسملل ةل َّجعلما ةحاتلإا ةردابلم ةيلحلما بتاكلما ةكبش ءاشنإ يغبنيو ضرف مدع يغبنيو .اهصيلختو اهئاشرو ةيودلأا بلط في ةيدادملإا تامدخلا .ةيرقهقلا تاسويرفلل ةداضلما ةيودلأا لىع بئاضر ةيأ 798 Bull World Health Organ 2009;87:794–798 | doi:10.2471/BLT.08.052027 Lessons from the field Access to antiretrovirals in the private sector in Africa S Van der Borght et al. 9. 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