Expanded Programme of Research, Development and Research Training in Human Reproduction: second annual report: appendices

INDEX WORLD HEALTH ORGANIZATION EXPANDED PROGRAMME OF RESEARCH, DEVELOPMENT AND RESEARCH TRAINING IN HUMAN REPRODUCTION · SECOND ANNUAL REPORT APPENDICES NOVEMBER 1973 • WORLD HEALTH ORGANIZATION ORGANISATION MONDIALE DE LA SANTE HR/73.5b ENGLISH ONLY WORLD HEALTH ORGANIZATION EXPANDED PROGRAMME OF RESEARCH, DEVELOPMENT AND RESEARCH TRAINING IN HUMAN REPRODUCTION SECOND ANNUAL REPORT The issue of this document does not constitute formal publication. It should not be reviewed, abstracted or quoted without the agreement of the World Health Organization. APPENDICES NOVEMBER 1973 Ce document ne constitue pas une publication. II ne doit faire l'objet d'aucun compte rendu ou resume ni d'aucune citation sans l'autorisation de !'Organisation Mondiale de la Sante. - 2 - APPENDICES TABLE OF CONTENTS Appendix A - Details of Expenditures and Estimated Financial Obligations as at 1. 2. 3. 4. 5. 6. 31 December 1973 • • • • • • • • • • • . • • . • • • • • • • . . Task Forces for Collaborative Research and Development Clinical Research Centres • , • • • • • • • , • • • Research and Training Centres on Human Reproduction. Research Training •• Other Programmes Programme Operations Appendix B 1. 2. 3. 4. Advisory Group Review Group WHO Staff and Consultants Major Activities, November 1972 - October 1973 3 4 31 33 34 38 50 52 53 56 57 - 3 - DETAILS OF EXPENDITURES AND ESTIMATED FINANCIAL OBLIGATIONS AS AT 31 DECEMBER 1973 APPENDIX A November 1973 - 4 - Appendix A 1. TASK FORCES FOR COLLABORATIVE RESEARCH AND DEVELOPMENT Expenditures and Estimated Obligations as at 31 December 1973 Task Force on Methods for the Regulation of Ovum Transport Task Force on Methods for the Regulation of Male Fertility Task Force on Methods for the Regulation of Sperm Migration and Survival in the Human Female Task Force on Methods for the Regulation of Implantation Task Force on the Use of Prostaglandins for the Regulation of Fertility Task Force on Immunological Methods for the Regulation of Fertility Task Force on Injectable Contraceptives Task Force on the Assessment of the Sequelae of Induced Abortion Task Force on Acceptability of Fertility Regulation Methods Other Task Forces Planning Meetings, Duty Travel and Consultants us$ 314 OOO 389 OOO 460 OOO 305 OOO 536 OOO 288 OOO 246 OOO 233 OOO 156 OOO 108 OOO 415 OOO Total 3 450 OOO A detailed computer print-out of research projects by task force and year of funding follows: 01/11/73 HR - FXPANDED PROGRAM - Pi~1.:JE:CTS BY TASK FOPC.i: ,V~1.1 SH T Jt.'>i TASK FORCE: 001 kEG!JLATION CF OVUM TRANSP"F.T SECT JDN: 007 TIJBAL !JCCLllS ION PROJECT NO. PROJECT TITLE Pr. INCI PAL INVESTIGATOR 00172 DEVELOP NEW CHEMICAL TUBAL KAR A.B. OCCLUSION METHODS & TRIAL IN RHESUS MONKEYS 00272 DEVELOP CHEM TUBAL OCCLUDING DUNCAN G.W. STERILIZING METHODS WITH SCLE- POSING AGENTS BUT NOT GRF 00372 DEVELOPMENT OF CHEMICAL TU~AL QUINONES R. OCCLUSION METHODS PHASE I CLINICA( STUDIES 00572 OEVELUPMEfH OF HYSTEROSCOPY AS OUINONES R. A METHOD FOR REGULATING FERTILITY 500573 EVALUATION OF HICROPOROUS IN- MARGOLIS A.J. TERFACE COATED FALLOPIAN TUBE PLUGS IN ANIMALS 00672 DEVELOPMENT OF HYSTEROSCOPY AS KUETSOWANG S. A METHOD FOR REGULATING FERTILITY 00872 DEVELOP HYSTEROSCOPY AS A METHOD FOR REGULATING FERTILITY 00972 DEVELOP HYSTEROSCUPY AS A HETHOIJ FOR REGULATING FERTILITY 501873 DEVELOPMENT OF REVERSIBLE INTRATUBAL OCCLUDING DEVICE DEVI P.K. RATNAH S.S. NUWAYSER E. S. INSTITUTION CENTRAL DttUG RESEARCH INSTITUTE LUCKNCW INOIA BATCLlf: INST.ITUTE SEATTL.E u.s.A. HOSPITAL GINECO OBST ETRICIA CFNTRO MEDIC NACIONAL MEXICO MEXICO HOSPITAL GINECO OBST ETRICIA CENTRO MfDIC NAC IONAL MEXICO MEXICO DEPARTMENT OBSTETRIC & GYNAECOLOGY SCHOOL MEO UNIV SAN FRANCIS u.s.A. FAHiLY PLANNING RfSE ARCH UNIT MAHIDOL UNIV. BANGKOK THAILAND POST GRADUATE INSTIT UTE OF MEDICAL EDUCA TION CHANOIGARH INDIA DEPARTMENT OBST./ GYNAECOLOGY KANDANG K. HOSP SINGAPORE SINGAPORE ABCOR INCORPORATED CAMBRIDGE MASS. u.s.A. S : SMALL 10NTPACT ALLPTMFNT * : PFnJf[f AT FINAL STAGf OF PEVIFW MA: NGT APPL[CABLE I NOT AVAtLaBLF INITI~l FUNDlijG Yf:A~ 72 72 73 73 73 73 73 73 73 TOT,\l BtJDfifT us t 60000 61400 2f\C('IC *NA* 910'.) * NA * *NA* *NA* 7 lt8 (' FIEST YEAR PUf>GET us$ 27000 47000 22500 2500 9100 4950 2700 2700 7480 SFCONI) YEA~ BUDGET us $ 33000 14400 5500 *NA* *NA* *NA* *NA* *NA* *NA* DURA- Tlll"; ( MPNT~!S) 24 24 24 24 24 24 24 ?.4 12 U1 I 01/11/73 HR - EXPANDED PROGRAM - PROJECTS UY TASK FORCE AND SETT IO~: S : SM,Ll CONTFACT ALL8TMFNT TASK FORCE: 001 REGULATION OF OVUM TRANSPORT SECTION: 007 TUBAL OCCLUSION * : ppnJECT AT FINAL ST~Gf nF PEVI~W ~~ : NOT APPLICABlf I N0T •VAILABLE PROJECT NO. PROJECT TITLE PR INC.I PAL INVESTIGATOR S05873 EVALUATION OF REVERSIBLE TUBAL RICHART R.H. OCCLUUING DEVICE (ABCOR) 508173 EVALUATION OF REVERSIBLE TUBAL NEUWIRTH R.S. OCCLUDING DEVICES (BATTELLE) *10473 CLINICAL STUDIES OF QUINACRINE NEUWIRTH R.S. TUBAL SUPPOSITORIES TO PRODUCE TUBAL STERILIZATION *10573 MODEL FOR OUT-PATIENT APPLI- RICHART R.H. CATION OF CHEMICAL AGENTS THROUGH THE FALLOPIAN TUBE 511473 FABRICATION OF EXPERIMENTAL TUBAL OCCLUDING PLUGS KITRILAKIS S. INSTITUTION COLLEGE PHYSICIANS & SURGEONS COLUMBIA UNIVERSITY N YORK u.s.A. COLLEGE PHYSICIANS & SURGEONS COLUMRIA UNIVERSITY N YORK u.s.A. COLLEGE PHYSICIANS & SURGEONS COLUMBIA UNIVERSITY NEW YORK u.s.A. COLLEGE PHYSICIANS & SURGEONS COLUMBIA UNIVERSITY NEW YORK u.s.A. TECNA CORPORATION EMERYVILLE CAL. u.s.A. INITIAL FUNDING YEfR 73 73 73 13 73 TOTAL. BUDGET us$ 7400 7400 13600 4590') 7450 FIRST YFAP BUDGET LIS$ 7400 7400 13600 45900 SHONLl Yf/\9 BUDGET us$ *NA* *NA* *NA* *NA* 7450 *NA* TOTAL FOR SECTION NO. 007 FINANCIAL OBLIGATIONS FOR 1972: 74000 142250 38830 FINANCIAL OBLIGATIONS FOR 1973: SMALL CONTRACT ALLOTMENT 1973 . . f)UPA- TJ 01\1 (Mtll\iTHS) 12 12 12 12 12 0) 01/11/7] HI< - EXPANDED Pl-:IJGRAM - N'llJff.TS l!Y T,\SK FOVCE !\N'J SEC:T ht• SMALi COIHR.ACT 111.LOTMENT TASK FORC[: CJOl REGULATION flf iJVUM TRANSPr:P-T s • :,J! PROJFf.T AT f!NAL STAGE OF REVIEW NOT APPLICABLE I ~OT AVAILABLE SECTION: :)09 CONTROL Of HUMAN >)VJ DUCT FUNCT (:JN PROJECT oo. ?kOJECT T ITU: PRINCIPAL INVF STI GATPR INSTTTUTION 01072 EFHCT VARIOUS rHAxMACOLUGICAL CK,1XATTO It. INSTITUTO CIENCIAS GIOLDGICAS LABORATOP ,1F FNDOCR SANT IAGfl CHILF AGENTS >lN EGG TKANSPCP T P·I WOMEN 01272 FACTU!<S CLJNT!<ilLLING Ml'TIL ITY Of HUMAN UVI ')UC r 01073 TUBAL MOTILITY ?ATTER~S I~ NORMAi. OVIJLAPlRY Aim MOOJFJED OVARIAN CYCLES 01172 BASELINE STUDIES ON TUBAL MDT I L ITY IN i~<lM,::r·J 03973 STUDIES OF NORMAL l'ATES IJF UVlJM TRA,~SPOl<l PAT,1N U.NI. FACULTY OF MEDICINE UNI VEKSJ TY OF ALBERTA CANADA lr'A,,RA-POU• 1\/1 THF!:E NATIONS PRO- GFAHME-CEBRE SArHJAGO CHI Lf. C!JlJTINHO E.!'. MATEHNIOADE OLIVERIO FAC MFO UNJVERSJDADA FEDERAL DE BAHIA tl~AZIL PAUrnSTEIN c.J. DFPAPT OBSTETRICS + GYNAl:CULDGY UNIV ,1F TEXAS SAN ANTONIO tJ.S.A. S07573 llF.VFLUPMPH Df i{AbillT EM·}f;YOS HAMNFk C.f. '.)f P.UF OoST .&GYN. umv. VIRGINIA LHARLUTTESVILLE VI~. u.s.A. DURING JN VITRO I•JCUBATI(Jt,1 *07973 !JEVfLOPMENT OF RABBIT EMl:IRYOS 1-!AtHlP C.E. UURING IN VIVO A!'.;) JN VITRO INCUBATION *09273 STUDY OF OVlm~AL CONTRACTILE BECK L.R. ACTIVITY IN A SUB-HUMAN PRIMATE (BABOON) S09573 EVALUAlION OF EGG DEVELOPMENT ADAMS C.E. ANO VIABILITY UNOER DIFFERENT ENDOCRINE CuNO.IN THE RABBIT OEP.Llf nBST.& GYN. IJNIV. VIRGINIA CHAPLOTTESVILLE VIR. u.s.A. OEP.UF 0~STET.&GYN. UNIV. OF ALABAMA BIRMINGHAM ALA. u.s.A. AGRIC.RESEARCH INST. CAMI\RIOGE UNITEO KINGIJOM INITIAi. FUNDING Y[A,, 72 72 73 73 73 73 73 73 73 TfJTAL BUDGET LIS $ 26.~0fl 41100 31900 16500 ll7400 6200 22000 48500 9400 FI PST Yf-AP BUOGFT us .$ 2201\0 19fifl() 15300 16500 43700 6200 22000 485!10 9400 TOTAL F•JI: Sf:C T l(IN NO. 009 FINANCIAL OBLIGATIONS FOR 1972 FINANCIAL OBLlf.ATIONS FOR 1973 SMALL CONTRACT ALLOTMENT 1973 TOTAL FOR TASK FORCE NO. 001 FINANCIAL OBLIGATIONS FOR 1972 FINANC1AL l!BLIGATIPNS ffl~ 1973 SMALL CO~TRACT ALLOTMENT 1973 SFCl'I\ID Yl:IIR BUDGET tlS $ 4300 21300 16600 * NA * 43700 • N.4 * * NA * •NA* * NA * 418'10 171600 156')0 115ROO 313850 54430 DURA- TION ( MONTHS) 24 24 24 12 24 12 12 12 12 ... 01/11/73 HR - EXPANDED PROGRAM - PROJECTS BY TASK FORCE AND SECTION S : SMALL CONTRACT ALLOTMfNT TASK FORCE: 003 REGULATION OF HALE FERTILITY * : PROJE[T AT FINAL STAGE UF REVIEW NA: N0T APPLJCAeLE I NOT AVAilABLE SECTION: 010 COORDINATION PROJECT NO. PROJECT TITLE 73001 CO-ORDINATION 73002 PREPARATION Of ANNUAL TF REVIEW & ARTICLE INITIAL FIRST PRINCIPAL FUNDING TOTAL YEAR INVESTIGATOR INSTITUTION YEAK BUDGFT AUOGH us$ us$ PAU...SEN A. DEPT HED SCHOOL MEO 73 17800 17800 U WASHINGTON SEATTLE u.s.A. DE KRETSER O.M. MONASH UNIVERSITY 73 355 355 MELBOURNE AUSTRALIA TOTAL FOR SECTION NO. 010 FINANCIAL OBLIGATIONS FOR 1972: FINANCIAL OBLIGATIONS FOR 1973: SMALL CONTRACT ALLOTMENT 1973 SECOND DURA- YEAR TION SUOGET (MONTHS) us$ *NA* 12 *NA* 12 18155 I ao 01/11/73 HR - EXPANDED PROGRAM - PPDJEf.TS P,Y TASK frJRCE flNll SECTJU', S : SMALL (0NTrACT ALLrT~f~T TASK FORCE: 003 REGULATidN OF HALE FERTILITY SECTION: 011 SPERHATOGENESIS * : PRflJFCT AT f-Pl/lL <;T,\.GF 'lF ?fVIFW NA: NOT APPLICABLE I NnT AVAILABLE PROJECT NO. PROJECT TITLE PR I NCI PAL INVESTIGATOR INST tTUTION 01773 CLI.STUDY-EFFECTS OF GESTAGEN- DE KRETSER D.M. MONASH UNIVERSITY ANDROGEN COMBINATIONS ON TES- MHBOIJRNE TICULAR FUNCTION IN HEN 03173 ANTI-FSH (INHIBIN) IN RETE TESTIS FLUID SETCHELL B.P. AUSH<ALIA AGR1CUl.TURL RESEARCII COUNCIL INSTITUTE CAMBRIDGE UJllITED Kl l<JGOOM *09173 EXP.STUDIES TO ISDL.&STUDY THE Df. KRETSEP n.M. MONASH UNIVERSITY PROP.OF ASEL.INHIBITOR OF FSH MELBOURNE SECRETION FRUM TEST.EXTRACTS AUSTRALIA INITIAL FIRST FUNDING TOTAL Yf:Ail YfAP. BUDGET BUDGET us$ us$ 73 68200 68200 n 58300 1530fl 7.3 74500 39800 TOTAL FOR SECTION NO. 011 FINANCIAL OBLIGATIONS FOR 1972: FINANCIAL OBLIGATIONS FOR 1973: SMALL CONTRACT ALLOTMENT 1973 SECCNO DURA- YcAP TIO"I ~IJOGET (MONTH<, us$ *NA* 12 2450() 36 34700 24 123300 <Q I 01/11/73 HR - EXPANDED PROGRAM - PROJECTS BY TA SK FORCF. AND SECT Fii'i TASK FORCE: 003 REGULATION OF HALE FERTILITY PROJECT NO. SECTION: 012 SPERM MATURATION PROJECT TITLE PRINCIPAL INVESTIGArnR INSTITUTION 01472 CLINICAL EFFECTS OF CYPROTERON HAMMERSTEIN J. l<LINil<UH STEGLITZ ACETATE ON HUMAN EPJDIDYMIS FRFIE UNIVERSITAT BERLIN 01572 TEST CYPROTERUNF. ACETATE IN ROY s.& PRASAO MAN AS A POST-TESTICULAR ANTI- FERTILITY DRUG 01672 STUDIES MECHANISM OF ACTION WHITE I.G. ALPHA-CHLOROHYDRIN + CYPROTER- ONE ACETATE 01772 SELECTIVE INHIBITION OF ANDRO- FRENCH F.S. GEN ACTION ON EPIDIDYMAL FUNC- TION&. SPERM MATURATION 01872 HICROVASCULAR ANATOMY OF HUMAN KO~MANO M. EPIDIDYMIS 01972 STUDY EPIOIOYMAL PERMEABILITY WAITES G.H. + ROUTES OF ENTRY OF COMPOUNDS. 01373 REGION DEPEND OF MATURATN CHAN BEDFORD J.M. GES IN NUCLEUS SURFACE SPERHAT OZA NORM ANDROG-DEF EPIDIDYMJS *01473 HORMONAL CONTROL OF EPIDIDYHAL FUNCTION BLAQUIER J. 02273 REGIONAL HISTOLOGY,CYTOLOGY&CY GLOVER T.O. TOCHEMISTRY HUMAN EPIOIDYMIS £ RELATN TO CONTAIN SPERMATOZOA NATIONAL INSTITUTE FOR FAMILY PLANNING NEW DEHL I INDIA DEPARTMENT VETERIN- ARIAN PHYSIOLOGY UN- VrRSITY Of SYDNEY AUSTRALIA LABORATORY REPROOUC- TIVf BIOL.UNIV.NORnt CAROL. CHAPEL Hill u.s.A. DEPARTMENT OF MEO CHEMISTRY UNIVER- SITY OF HELSINKI FINLAND DEPARTMENT OF PHYSI- OLOGY & BIOCHEMISTRY READING UNIVERSITY UNI TED KINGDOM CORNELL UNIVERSITY MEDICAL COLLEGE NEW YORK u.s.A. INST.BIOL.Y MEOICINA NAT.RESEARCH COUNCIL BUENOS AIRES ARGENTINA UNIVERSITY OF LIVER- POOL UNITED KINGDOM $ ,. ~ NA INITIAL FUNDING YF:Af n 72 72 72 72 72 73 73 73 Sf"t\LL CfHJTfU.ICT tillfiTMP;T PRl'JFCT f\.T FINAL STI\GF •.1F RF:IIH,J NPT APPLICAPLi' I "lOT l'VAILA'3LF. TOTl\l. guoGF:T us$ 39200 :-n 000 37600 19700 2730'1 43300 ~8100 972')0 '3 'Hin r: FIRST YEAR BlJOGfT us 1- 25700 14(')0() 17000 19700 16400 15400 19800 HlOO 11rnoo SECON!J VfAR ~UOGH us$ 13500 17000 ?0600 *NA* 10'100 14000 18300 2981)() 15ROO OUF !I- T I ON , Mmin;sl 24 24 24 12 24 36 24 16 24 .... 0 01/11/73 HR - EXPANDED PROGRAM - PROJECTS BY TASK FORCE AND SECTION S : SHALL CONT?ACT ALLuTME~T TASK FORCE: 003 REGULATION OF HALE FERTILITY * : PROJECT AT Fl~AL STAGF OF REVIFW NA: NOT APPLICABLE I ~OT AVAILABLE SECTION: 012 SPERM MATURATION PROJECT NO. PROJECT TITLE PRINCIPI\L INVESTIGATOR 02373 FACTORS AFFECT CHEMICAL COMPOS GLOVER T.D. ITION EPIDIDYMAL FLUID&RELATN TO SPERM SURVIVL IN MALE TRACT 506073 CHARACTERIZATION OF SPECIFIC ANDROGEN CARRIER & RECEPTOR PROTEINS FRENCH F.S. •09673 ANALYSIS OF EPIDIDYMAL LUMINAL SETCHELL B.P. CONTENTS COLLECTED BY MICRO- PUNCTURE TECHNIQUES *09873 SELECTIVE INHIBITION OF ANDRO- FRENCH F.S. GEN ACTION ON SPERMATOGENESIS AND SPERM MATURATION INSTITUTION UNIVERSITY OF LIVER- POOL UNITED Kl NGOOH LABORATORY REPRODUC- TIVE BIOL.UNIV.NORTH CAROL. CHAPEL HILL u.s.A. AGRJCULTURL.RESEARCH COUNCIL INSTITUTE CAMBRIDGE UNITED KINGDOM LABORATORY REPRODUC- TIVE BIOL.UNIV.NORTH CARot.. CHAPEL HILL u.s.A. INITIAL FUNDING YEM~ 73 73 73 73 TOTAL BUDGET us$ 57000 4500 63700 79500 FIRST YEAR BUDGET us$ 18500 4500 20500 39000 SECOND YEAR BUDGET us$ 18600 * NA * 20100 40500 509973 IDENTIFICATION OF FUNCTIONAL ELIASSON R. KAROLINSKA INSTITUTE STOCKHOLM 73 15000 15000 •NA* PARAMETERS IN HUMAN SPERMATOZ. RELATED TO MALE FERTILITY SWEDEN 73005 PROVISION OF SAMPLES OF HUMAN POMEROL SERRA J.INSTITUTO DE UROLOG. 73 8700 8700 TESTICULAR TISSUE FUNDACION PUIGVERT BARCELONA SPAIN 73006 PROVISION OF SAMPLES OF HUMAN SCHOYSMAN R. DEP OF ANDROLOGY UNIV.HOSPITAL BRUG- 73 7500 7500 TESTICULAR TISSUE MANIII BRUSSELS BELGIUM TOTAL FOR SECTION NO. 012 FINANCIAL OBLIGATIONS FOR 1972: FINANCIAL OBLIGATIONS FOR 1973 SMALL CONTRACT ALLOTMENT 1973 TOTAL FOR TASK FORCE NO. 003 FINANCIAL 'lRLIGATIONS FOR 1972 Fl~ANCIAL n~LIGATIONS FOR 1q73: *NA* *NA* 108200 24710'> 19'>00 108200 31'18555 DURA- TION (MONTHS) 36 12 36 24 12 12 12 .... .... I 01/11/73 HR - EXPANDED PROGRAM - PROJECTS BY TASK FORCE ANO SECTION S : SMALL CONTRACT ALLOTMENT TASK FORCE: 004 SPERM MIGRATION AND SURVIVAL * : PROJECT AT FINAL STAGF. OF REVIEW NA: NOT APPLICABLE I NOT AVAILABLE SECTION: 023 MEDICATED VAGINAL RINGS PROJECT NO. PROJECT TITLE 02072 PREPARATION t ASSESSMENT SJLASTIC VAGINAL DEVICES CONTAINING PROGESTJNS 00473 DEVELOPMENT OF A DEVICE PRINClPAL INVESTIGATOR DUNCAN G.W. ALZA CORP. 05373 CLINICAL ACCEPTANCE STUDIES OF MISHELL D.R. SILASTIC+2 PROPRIETARY POLYMER VAGINAL RINGS INSTITUTION BATEL LE INSTITUTE SEATTLE u.s.A. ALZA CORPORATION PALO ALTO CAL. u.s.A. PROF. STAFF ASSOC. UNIV. S. CALIF. LOS ANGELES u.s.A. INITIAL FUNDING YEAR 72 73 73 TOTAL BUDGET us$ 60300 42800 2500 FIRST YEAR BUDGET tJS $ 41000 42800 2500 SECOND VF.AR BUDGET us$ 13300 * NA * *NA* *11273 PHASE 1 STUDY OF VAGINAL RINGS 4 INVESTIGATORS HAGENFELT, UASPELS 13 28600 28600 *NA* CONTAINING A PROGESTAGENIC HUBINOT, GUAL COMPOUND 73003 COORDINATION: VAGINAL RINGS - DUNCAN G.W. BATTELLE INSTITUTE SEATTLE u.s.A. TUBAL OCCLUSION-MEDICATED IUDS TOTAL FOR SECTION NO. 023 73 5000 5000 *NA* FINANCIAL OBLIGATIONS FOR 1912: FINANCIAL OBLIGATIONS FOR 1973: SMALL CONTRACT ALLOTMENT 1973 . . 47000 92200 DURA- TION f MONTHS) 24 12 12 07 12 .... Ill) 01/11/73 HR - EXPANDED PROGRAM - PROJECTS BY TASK ff)RCE AND SECT JQN TASK FORCE: 004 SPERM MIGRATION AND SURVIVAL SECTION: 024 CERVICAL CONTRACEPTION PROJECT NO. PROJECT TITLE PRINCIPAL INVESTIGATOR 02172 DEVELOPMENT OF INTRA CERVICAL DAVAJAN V. DEVICE 02272 PREPARATION+PRECLINICAL ASSESS DUNCAN G.W. MENT MECHANICAL+ORUG RcLEASING CERVICAL CONT~ACt.PTIVE DEVICES 02372 STUDY RHEOLOGICAL PROPFRTIES AND EFFECTS OF CALCIUM NAKAMURA R.H. 02472 INFLUENCE METALLIC+ STEROIDAL KESSERU E. AGENTS ON IN VITRO SPERM MIGRA TION THRU HUMAN CERVICAL MUCUS INST ITUTIUN WOMENS HOSPITAL UNIV S CALIF MEO CENTER LOS ANGELES u.s.A. BI\TfLLE INSTITUTE: SEATTLE u.s.A. PRCJF. STAFF ASSOC. UNI V. S. CALI F. LOS ANGELES u.s.A. MARCELLINO RESEARCH INSTITUTE UNIVERSITY Of CAYETANO LIMA PERU 00273 ESTABLISHMENT SCREENING MODELS SETTLAGE o.s.F. PROF. STAFF ASSOC. TEST SPERMICIDAL AGENTS IN UNIV. S. CAlIF. CERVICAL MUCUS LOS ANGELES u.s.A. 00373 STUDIES ON CERVICAL MUCIN & SPERM fllllGRATION 00673 STUDY ON MACROMOLECULAR CONTENT OF CERVICAL MUCUS & CERVICAL EPITHELIAL CELLS MOGHISSI K.S. FERIN J. DEPART REPRODUCTIVE BIOLOGY WAYNE STATE UNIV DETROIT u.s.A. PHYSIOL HUMAN REPROD RES UNIT DEP EXP MEO UNIV CATH OE LOUVAIN BELGIUM 00873 LOW MOLECULAR WEIGHT PROTEINAS SCHUMACHER G.F. DEPARTMENT OBSTETRIC INHIBITORS IN HUMAN CERV MUCUS + GYNAECOLOGY UNJVER DURING PRESUM OVULATORY CYCLES SITY Of.CHICAGO u.s.A. 02873 ACROSOMAL PROTEINASES & PROTE- FRITZ H. INASE INHIBITORS: MOLECULAR ASPECT Of INTERACTION INSTITUT KLINISCHE CHEMIE+ BIOCHEMIE UNlVERSITAT MUNCHEN S : SHALL CONTPACT ALLOTMENT * : PROJfCT AT FIN•L STAGF ~F ~~VtFW NA: NOT APPLICMU.f I NflT f\V.AJU.f'LE INIT l Al FUNDING YEM' 72 72 72 72 73 7'1 73 73 7) TOTAL BUOGFT us$ 48700 77700 397.00 30()00 45700 84200 67900 65000 60600 FIPST YEAf: BUOGf:T us$ 241<)() 4521)0 19800 16000 22200 27500 39600 28300 32800 SFCPN!i VEAR BUDGET us 1,; 2460() 32500 19400 14000 23500 29200 28300 36700 ~7800 DURA- TION (MONTHS) 24 24 24 24 24 36 24 24 24 .... (.) I 01/11/73 HR - EXPANDED PROGRAM - !>ROJECTS tlY TASK FO!lCE AND SECTIDN SM~LL CONTPACT AlLOTMfNT TASK FORCE: 004 SPERM MIGRATION ANO SURVIVAL ;:, * N.4 PROJECT AT rIN~l ST!\Gr ,1r flfVItW NOT QPPll(AALF I ~nT ~VAILARLE SECTION: 024 CERVICAL CONTRACEPTION INITI.U FIR~T PROJECT PRINCIPAL FUND WG TDDL Yb'H' NO. PROJECT TITLE INVESTIGATOR INSTITUTION YFAR BUDGF:T bUDGE:T us$ us$ 03273 COMPAR BIOPYSICAL STUDIES META OOEBLAD E. Of?ARTMENT MEDICAL 7:,, 3850fl 22000 LS CHEMICALS THAT AFFECT SPERM PHYSICS UMEA UNIVER- MIGRATION THRtJ CERVICAL MUCUS SITV SWEOE:-.i 06973 LOW MOLECULAR WEIGHT PROTEINAS RAJAN! C.M. LADY HARDING MEDICAL 71 16000 7700 INHIBITORS IN HUMAN C[P.V MUCUS CULL EGE DURING PRESUM OVULATGRY CYCLES NEW DEHL I INDIA *10173 DISTR.Of TRACE ELEMENTS BTW. ELSTEIN M. DcP.nF HR t OBSTET. n 4450!') 2150() CC~PONENTS OF CE~V.MUCUS IN UNIV.Of SOUTHAMPTON REL.TO THE DEV.MENT Of ICDS SOUTHAMPTON UNITED KINGDOM TOTAL FOR SECTION NO. 024 FINANCIAL OBLIGATIONS FOR 1972: FINANCIAL OBLIGATIONS FOR 1973 SMALL CONTRACT ALLnT~ENT 1973 : SECPMD YE.4? BI JO GET us $ 8400 :non 23000 10.5100 n2100 PURA- TION ( ~01\iTHS) 36 24 24 ... ,,,. 01/11/73 HR - EXPANDED PROGRAM - PRn.JECTS BY TASK FORCt ANO :SECT ln"l Sl.tALL CU'lTkJ\CT ~LLl!TMf.NT TASK FORCE: 004 SPFRM MIGRATION AND SURVIVAL s * !\IA PROJFCT AT FINAL STAGE ~f 1FVIEW NCT I\PPLJCI\F\l E I NUT AVAll.rlBLE: SECTION: 025 EFFECTS OF PHYS. FACTORS & CURR. METH. UN SPERM IN UTEkUS PROJECT NO. PROJi:CT TITLE PRINCIPAi. 11\!VESTIGATOf? 02572 INFLUENCE INTRAUTERINE ENVIRON.BERNSTEIN G.S. ON MOTILITY METABOLISM PHAGO- CYTOS OF HUMAN SPERHATOZUA 02672 METABOLISM AND SURVIVAL OF SPERM 02772 BIOCHEMISTRY Of SPERM WITH REFERENCE TO UTFRLIS AND ACT ION OF SPERMICIDES JANNE J. WHITE J.G. S00973 COPPER INTRAUTERINE CONTRACF.P- MAYNARD P.V. TION X-RAY MICPOANALYSIS OF HUMAN SPERM CELLS INSTITUTION Of.P. U8STR. & GYN. UNIV. S. CALIF. LltS ANGFLES u.s.A. DEPART MEDICAL CHEMI STRY UNJVERSJTY Of HELSINKI FINLAND DEPART VETERINARY PHYSIOLOGY UNIV. OF SYDNEY AUSTRALIA TENOVUS INST CANCER RESEARCH WELSH NAT. SCHOOL MEO. CARDIFF UNITED KINGDOM IN IT lAl. FI!' ~T FUN'.1 ING T\1TAl. Y~AF V<=Aq_ BIJD<;:C:T f\lJDGf.T us$ us $ 7:>. 550')0 289()0 72. 79400 22000 n ,;9000 17000 73 5500 5500 TOTAL FOR SECTION NO. 025 FINANCIAL OBLIGATIONS FOR 1972: FINANCIAL OBLIGATIONS FOP 1973: SHALL CONTRACT ALLOTMFNT 1973 : TOTAL FOR TASK FORCE NO. 004 FINANCIAL OBLIGATIONS FOR 1972: FINANCIAL OBLIGATIONS FOR 1973: SMALL CONTRACT ALLOTMENT 1973 . . Sf:-CflNO DUPII- YEI\R TION RUOGET ( lolOfHHS t us$ 26100 24 28700 36 2050') 36 *NA* 12 67900 75300 5500 220000 459600 5500 ..... (II 01711/73 AR - EXPANDED PROGRAM - PROJECTS BY TASK FORCE AND SECl luN s : SMALL CONTRACT ALLOTME~T TASK FORCE: 002 REGULATION OF IMPLANTATION * : PROJECT AT FINAL STAGE OF ~EVIEW NA: NOT APPLICABLE I NOT AVAILABLE SECTION: 015 INTRAUTERINE MEDICATION INITIAL FIRST SECOND DURA- PROJECT PRINCIPAL FUNDING TOTAL YEAR YEAR TION NO. PROJECT TITLE INVESTIGATOR INSTITUTION YE=AR BUDGET BUDGET BUDGET I MONTHS) us$ us$ us$ 04173 DETERMINATION PROSTAGLANOINS HAGENFELOT K. KAROLINSKA INSTITUTE NA *NA* •NA• •NA* 06 IN ENDOMETRIUM WOMEN BEFORE & STOCKHOLM DURING USE INTRAUTERINE DEVICE SWEDEN 04273 TRANS EXAMIC ACID VIA INTRAUTE HAGENFELDT K. KAROLINSKA INSTITUTE NA •NA* •NA* •NA* 06 RINE ROUTE-RESORPTN+INFLUENCE STOCKHOLM UTERINE FIBRIOLYTIC ACTIVITY SWEDEN 04373 ALZA 1 S UTERINE PROGESTERONE ALZA CORP. ALZA CORPORATION NA *NA• *NA* *NA* 18 SYSTEM PALO ALTO CAL, u.s.A. 05073 ALZA T PROGESTERONE INTRAUTER- HAGENFELDT K. KAROLJNSKA INSTITUTE NA *NA* *NA* •NA• 06 INE DEVICE STOCKHOLM SWEDEN .... 0) 04573 DEVELOP CLINICAL STUDIES IN MOYER D.L. PROF. STAFF ASSOC. 72 Vt815 16015 8800 24 USE OF MEDICATED IUDIWITH CRCS UNIV. S. CALIF. IN BRUSSELS IBAOAN UTRECHT) LOS ANGELES u.s.A. 00773 STUDY MODE ACTION,TOXIC TESTNG HOYER O.L. PROF. STAFF ASSOC. 73 60300 30600 29700 24 +MORPHOL RESPONSE OF HEDICATN UNIV. S. CALIF. DESIGNED FOR USE IN MEDIC IUD LOS ANGELES u.s.A. 01973 CONTRACEPTIVE EFFECTS IN WOMEN GOMEZ-ROGERS C. DEPART OBSTETRICS+ 73 12000 12000 *NA* 12 OF UTERINE PROGESTERONE SYSTEM GYNAE. UNJV OF CHILE CU-72-5E) ALZA CORPORATION SANTIAGO CHILE 02573 STUDY PHYSICAL+BIOCHEMICAL CON LEBECH P.E. DEPART OBSTETRICS• 73 1600 1600 *NA* 12 STITUENTS OF CERV MUCUS IN WOM GYNAECOLOGY FREDRIKS EN WITH ALZA l INTRAUTER DEVIC BERG HOSP COPENH DENMARK 02673 HORMONAL STUDIES IN WOMEN WITH NEWTON J.R. KINGS COLLEGE HOSPI- 73 6000 3000 3000 24 ALZA T PROGESTERONE RELEASING TAL LONDON INTRAUTERINE DEVICE UNITED Kl NGDOM 01/11/73 HR - EXPANDED PROGRAM - PROJECTS BY TASK FOPCE AND SECTIQ~ TASK FORCE: 002 REGULATION OF IMPLANTATION SECTION: 015 INTRAUTERINE MEDICATION PROJECT NO. PROJECT T ITU: PRINCIPAL INVESTIGATOR 04473 COMPARATIVE CLINICAL TRIAL OF tJJO o. ALZA PROGESTERONE LIPPES LOOP INTRAUTERINE DEVICES 04673 INFLUENCE HED INTRA UTEPINE DE GALLEGOS A.J. VICES ON BIOCHEMICAL COMP META BOLISM+STRUCT HUH ENDOMETRIUM 04773 SEARLE-LEH POST-PARTUM PROTOCOL 04873 SEARLE~LEM POST ABORTION PROTOCOL WHO WHO INSTITIJTIOI\I DEPART OBSTETRICS+ GYNAECOLOGY UNIVER- SITY JBADAN NIGERIA BIOL RtP DIVISION INST. MEX.SEGURO SOCIAL MEXICO C. MEXICO WHO WHO 05173 PHASE III/IV ALZA T STUDY KWON E.H-PAI D. SEOUL NATIONAL UNIVERSITY RfPUBLIC OF KOREA *06573 ELECTRON MICROSCOPY OF HUMAN HOHMAN W.R. PROF.STAFF ASSOCIAT. ENOOMETRIUM I Ii CONTACT WITH UNIV. SOUTH CALIF. MEDI CAT ED IUDS .LOS ANGELES u.s.A. 07273 ALZA T STUDY NEWTON J.R. KINGS COLLEGE HOSPI- TAL LO NOON UNITED K INGDUH 07373 ALZA T STUDY LE BECH P. E. DEPART OBSTETRICS & GYNAECOLOGY FREDRIKS 8.ERG HOSP COPENHAGEN DENMARK *10373 ENOOHETRIAL CHANGES INDUCED BY GALLEGOS A.J. BIOL.REP.DIVISION ACTIVE IU-DEVICES CONTAINING INST.MEX.SEGURO DIFFERENT PROGESTOGENS SOCIAL MEXICO au:vTrn .. ,:, * i'lA INITIAL FUNf:ING YEAK 73 73 73 73 73 73 73 73 73 SMhLL [ONTR4CT ILL0T~FNT PPOJFCT AT flNAL ~TAr,F SF RFVlf~ NOT APPLJC.At>Lf I NOT AVAIL.ABLE TOTAL BlJOGH us$ 600 i5600 20000 2000() 4000 8900 4000 1800 14000 FIF<ST YEA~ !3UOGFT us$ 600 9900 10000 10000 4000 8900 40()0 1800 1400(' Sl:'CllNI) YEAR ,)tJOGET us$ *NA* 5700 10000 10000 *NA* *NA* *NA* *NA* *NA* OURA- TifJN ( "10NT!-lS) 12 24 24 24 12 12 12 12 12 .... ..;i 01/11/73 HR - FXPANDED PPOGRAM - PR8JECTS BY TASK FQRCf AND SECTION s SMALL CONTRACT ALLOTMENT TASK FORCE: 002 REGULA T JON Of IMPLANT.a TI ON "' Nh PROJECT AT FINAL STAGE Of ~EVJEW NOT APPLICABLE I NOT AVAILABLE SECTION: 015 INTRAUTERI~E "EDICATJ~N PROJECT NO. PJIOJECT TITLE PRINCIPAL JNVESTIG~T· INSTITUTION *10673 STUDIES OF f.N00'4.£. )1YUM.i'LASM. SH!lh S.T. PH:f.~TAFF ASSOCIAT. UNIV. SOUTH. CAl.IF. LOS ANGELf.S ACTIVATOR& ENi)(]M.FLUIO PIASMJN PLASMINOGEfll AND PLASM.I\CTIVAT. *10773 S TUOY flf COAGULATION fACTf)~. S l N ENDPMETRl AL FU.II O SHAW S. T. u.s.A. PROF.STAFF ASSOCIAT. UNIV. SOUTH. CALIF. LOS ANGEU:S u.s.A. *10873 LIGHT£.t:l..MICROSC.STUfHrS-Hfl1AT HUHMAN w.~. £.VASCULAR ASPS.ENDOM&MYOM.FRO~ PROF.STAFF ASSOCIAT. UNIV. SOUTH. CALIF. LOS ANGELES UTERI CONTAINING IUDS IJ.S.A. *10973 ENDOM.OIOPSIES HYSTERUCOPIAL. ISRAH R. PROF.STAFF ASSOCJAT. UNIV. SOUTH. CALIF. LOS ANGHES STUDY PLASMINUGEN ACTIVATOR IN UTERI CONTAINING Ill CONTR.OEV. U.S.A. *11173 EFFECT Of 1U MEOICAT JON JN THE 3 JNVESTIGAT!,RS l\ENGTSSON-LUNCI MOTILITY Of THE NON-PREGNANT COUTINHO-SALVADOR HUMAN UTERUS ESKES-NIJMEGEN *11373 CLINICAL STUDIES WITH THl CHLOROQUINE T IUD *11873 DEVELOPMENT OF CLINICAL STUDifS IN THE USE 0F MFOICATEO IUDS 512273 EFFECT OF IUD ON [STPAJH•1L PROGEST ERON[ AND P. GlANDI N LEVELS IN ENOOMETPIUH 512973 ANTI Pi<U6[ STATI O,liAL AGENTS FEASIBILITY STU~Y 3 I NVESTI Gl\fl'JRS HASPEL S-UTl<ECHT HUR I NOT-BRUSSELS !JJ,l-1 BAD AN 3 INVESTIGATORS HASPfLS-UTRECHT IJUB I NtH-BRUSSELS OJD-IBADAN SPERtlFF L. TERENIUS L. DEP. OBST. & GYN. YALE UNIV.SCHUOL MEO NEW HAVEN CONN. u.s.A. OfP.MEn.PHARMACOLUGY UIHV. llF UPPSALA Uf>PSAU\ SloEDHJ INITIAL fUNOTNG Yff:..>: 7? 73 n 73 73 73 73 73 71 Tf1TAL BUOGFT u~. s 31900 9700 20500 7700 45200 950('! 3400 665() 7500 FIRST YEAP. BUDGET us i 31AOO 9700 2050() 77'JO 45200 9500 3400 6650 7500 .TOTAL FOP Sl=CTION NO. 015 FINANCIAL OBLIGATICNS FflR 1972 FJNANCIAL llBL IGATIO"IS FOR 1973 SHILL CONTRACT ALLOTMENT 1973 SECOND YEAP BUDGET us $ * NA * * NA * *NA* *NA* *NA* *NA* *NA* *NA* *NA* 16015 247000 14150 DURA- TlfJN C MOfllTHSI 12 12 12 12 12 18 24 12 12 ... OD 01/11/73 HR - EXPANDED PROGRAM - PROJECTS HY TASK FORCE ANO SECTitli', 5 : SM>\Ll CONTRACT ALLOT"'IENT TASK FORCE: 002 REGULATION OF IMPLANTATION * : PROJECT AT FINAL STAGE OF REVIEW 'IA : NOT APPL I CABLE I ;-.ior AVAILABLE SECTION: 017 OTHER METHODS TO DISRU~T IMPLANTATION INITIAL FrnST SECOND DURA- PROJECT PRINCIPAL fUNOl!ljG TOTAL YFAR YEAR TION NO. PROJECT TITLE INVESTIGATOR INSTITUTION YfAf:' BUOGFT SUD GET BUDGET ( MONTHS) us$ us $ us$ 05773 SCREEN 3 COMPOUNDS IN 1 YEAR GOLDZlEHER J.W. SOUTHWEST FOUNDATION 73 513100 58100 *NA* 12 FOR CONTRACEPTIVE ACTIVITY IN FOR EDUCATION+ RE- BABOONS SEARCH SAN ANTONIO u.s.A. 510073 EFFECTS OF GLYPRESSIN ON BENGTSSON L. DEP.OF OBSTET.&GYN. 73 7'>00 7500 *NA* 12 HYOMETR IAL ACTI V ITV IN THE UNIVERSITY OF LUND NON-PREGNANT WOMAN LUND SWEDEN 511573 HETEROLOGOUS IMPLANTATION NILSSON O. INST.OF HUMAN ANAT. 73 3350 3350 *NA* 12 IN VJTRO UNIV. OF UPPSALA UPP SALA SWEDEN TOTAL FOR SECTION NO. 017 FINANCIAL OBLIGATIONS FOR 1972: FINANCIAL OBLIGATIONS FOR 1973: 58100 SMALL CONTRACT ALLOTMENT 1973 : 10850 ~ ~ I TOTAL FOR TASK FORCE NO. 002 FINANCIAL OBLIGATIONS FOR 1972: 16015 FINANCIAL OBLIGATIONS FOR 1973: 305100 SMALL CONTRACT ALLOTMENT 1973 . 25000 . 01/11/Tj HR - t'XPA"l')EO PROGRAM - l'FC)Ji:CTS ;:W Ti',SK FORCE ANL SffTION TASK FORCE: 005 PROSTAGLANDH,S StCTION: 018 PG FOR TER~INATION OF PRtGNMJCY PROJECT NU. PROJ Ec:T TIT LE ?RINCI PAL INVf:STIGAT\W INSTITUfHlN 02872 PHASE III CLINICAL TRIAL PROST ~GRELL u. KAFOLI~SKA HOSPITAL STOCKH~LM AGLANOIN F2-ALPHA-SALINE COUMD I NATION SWf11t:N 03772 SET UP AND RUN JJATA PROCESSING HARKINS J. UNIVERSITY OF TORONTO SYSTEM fOR PHASE Ill TRIAL 02972 PHASE III CLI~ICAL TRIAL 03072 PHASE III CLINJCAL TRIAL 03172 PHASE III CLINICAL TRIAL 03272 PHASE III CLINICAL TRIAL 03472 PHASE III CLINICAL TRIAL 03572 PHASE III CLINICAL TRIAL 03672 PHASE III CLINICAL TRIAL CANADA PURANDARE V.N. INSTJTUTE RESV:ARCH REPRO BIOL GS SETH MEO.COLL. BOMBAY INDIA HINGQRANI V. ALL INOIA INSTITUTE OF MEDICAL SCIENCES NEW OEULI I NOIA DEVI P.K. POST GRADUATF !NSTI- TUTE OF MEDICAL EDU- CATION CHANOIGARH INDIA HUSAR H. GINEKOLOSKO-AKUSERSK KLI NI KA BEOGRAD YUGOSLAVIA RAJKOVIC V. GINEKOLOSKO-AKUSERSK BOLNICA BEOGRAD YUGOSLAVIA SZONTAGH F.E. DEPART OBSTETRICS+ GYNAECGLOGY MEDICAL SCHOUL UNIV SZEGED HUNGARY QUILLIGAN [.J. PROF. STAFF assoc. UNIV. S. CALIF. LU~ ANGFU:S u.s.A. 5 : SHALL CGNT~ACT ALLnTMFNT * : PR[•JFCT •\T FINAL STAGf llf REVIF_W NA: NOT AD?LICABLE I ~OT AVAflABLE INITIAL FUNDING Y"AF 12 7? 73 73 13 73 73 13 73 TflTl\l. flUOGH us$ 46r1 1)<"' 18350 60('0 6001) 6000 4000 4000 4()()) 15{'';') FIRST YFA!<' BUDGET us .$ 21000 5600 6000 60('0 6000 4000 4000 4000 150')(') SECONl1 YFAR BUDGET us$ 25000 127'5:-1 *NA* * NA * *NA* *NA* *NA* *NA* * NA * OUPA- TifiN IMO~THS) 24 24 12 12 12 12 12 12 12 I t,:, 0 01/11/73 HR - EXPANDED PROGRAM - PRflJfCTS RY TI\SK FORCE ANfl SlUI 11H TASK FORCE: 005 PROSTAGLANiHNS SECTION: 018 PG FOR TERMINATION OF PRtG~ANCY PROJECT NO. PRUJECT TITLF: 03872 PHASc Ill CLINICAL TRIAL 11773 PG CLINICAL TRIAL PHASE 2 B 4 CRCS 90073 PHASE II 1 CLINICAL TRIALS OF PG ANALOGUES 90173 EXPANDED.PHASE I ANO II CLINICAL TRIALS Of NEW PG ANALOGUES PRINCIPAL INVEST I GA TUF KINCH R. BORELL u. 15-20 CENTRES 4 CENTRES INSTITUTION GF:Nf.PAL HOSPITAL MC GILL UNIVERSITY MONTREAL CANAOA KARULINSKA INSTITUTE STOCKHOLM SWEOEN MULTI CENTRE CLINICAL TRIAL HUL TI CENTRE CLINICAL TRIALS ::, * N" l"HT I AL FUNf'II·'•G y t .\~: 73 73 B 73 SMALL cnNlk~CT ALLOTMENT ppnJ~CT I\T FINAL STAG[ ~F ~FVIF~ NUT ,\PPLICI\H.[ I MOT iW~Jl4'3LF t-n ST su:oNn i:1URI\- Ti'TAL ntir YEAR TH'~• PIJ['i;n HlnGFT ~IJOGf. T ( MO~'THS) us$ us 1 •JS $ "'>ll()() Vi00C * t!A ~ 12 12000 12000 *NA* l fl 80000 80000 *NA* 12 3000() 30000 * NA * 12 TOTAL FOR SECTION NO. 018 FINANCIAL OBLIGATIONS FOR 1972: 26600 z397i;o FINANCIAL OBLIGATIONS FOR 1973 : SMALL CONTRACT ALLOTMENT 1973 : I I\) ... 01/11/73 tlR - EXPANDED PHOGRAM - PKi!JECTS BY TASK FORCE ANt1 SffT ~tl:': S~'ALI. CUII-T'!ArT .~1.u·T'·H~;T TASK fORCE: 005 PRflSTAGLANl>INS s * ~!A PR·1J~CT AT f'.H,,-\L STAt;f dF ll"VIH, f\!UT APPl.ICAt;Lf I ,j11T J\V~JL\SLf' SECTION: 019 METABOLISM PG£ ANALOGUES & DEVELOP ANALYTIC METHUOULOGY PROJECT NO. PROJECT T ITU: 04072 ANALYTIC METABOLIC STUDIES 04172 HETASOLIC MDNITOMING PRINCIPAL INVESTIGATOR BCRGSTROM S. KINCH R. IMSTITUTION l<AROLINSKA INS TlTUTE STOCKHOLM SWEDEN GfNflU•.L HOSPITAL MC GILL UNIVERSITY MflNTRFAL CANADA I NIT l I\L FIRST FIINOING TOTl\L YU\R VE1W fllJDGH dUDGET 05 $ us$ 72 721901' 15f.'"l00 7·~ .. 1<}2400 3000(\ TOTAL FOR SECTifJN NU. 019 FINANCIAL ORLJGATIONS FOR 1972 FINANCIAL CBLIGATIONS FOR 1973 SMALL CLJNTRACT ALLOTMENT 197~ SECOND YEAR fllJDGET us$ 11()000 33()!)0 186900 1430()(' our<\- TlON ( MO~JTYS) 60 6(' II:> II:> 01/11/73 HR - EXPANDED PROGRAM - PROJECTS JY TASK FOPCE ANU SECT10~ PROJECT NO. TASK FORCE: 005 PRCSTAGLANDINS SECTION: 021 PG AS CONTRACEPTIVE ANO/OR MENSES INCUCER PROJECT TITLE PRINCIPAL INVESTIGATOR 03972 PHASE I+II CLINICAL TRIALS BORELL U. S03373 INVESTIGATION OF POSSIBLE JONES W.R. LUTEOLYTJC ROLE INTRAUTERINE PGF2A IN NON-PREGNANT FEMALE *11673 DEVELOPMENT OF TARGET flRGAN SAMUELSSON 8. SPECIFIC RECEPTOR SITE SCREEN. SYSTEMS FOR PG ANALOGUES INST ITIJTION KAROLINSKA HOSPITAL STOCKHOLM SWEDEN QUEEN ELIZABETH 11 RES INST MOTHER+ EN- FANTS UNIV SYDNEY AUSTRALIA KAROLINSKA INSTITUTE STOCKHOLM SWEDEN s * !\~A !NIT I Al FUNOING VF.AR 1?. 73 73 SMALL UWT:<M:T ALUlTMf",; f PRf"iJFCT H FJt:AL C:T~(;f .-JF H:V!Fii' NUT AP 0 LICA6LE I ~PT AV~fld~LF FIRST SfCO"!D OUP.A- TfiTI\L YEAP Yf A? TiflN SUOGFT ::!UOGET H!JDGET ( '°'uNTH.<;) ttS $ us$ !JS$ 300000 45000 '>Ot'OO 60 4200 4200 *NA* 12 1820iJO 74800 52500 36 TOTAL FOR SECTION NO. 021 FINANCIAL OBLIGATIONS FOR 1972: 45000 124800 4200 FINANCIAL UBLIGATIONS FOR 1973: SMALL CONTRACT ALLOTMENT 1973 Ill) w 01/11/73 PROJECT NO. HR - EXPA~OED PROGRAM - PROJECTS RY TASK FORCE AND SECT ION TASK FORCE: 005 PROSTAGLANDINS SECTION: 022 COORDINATIUN & DATA PROCESSING PROJf:CT TITLE PRINCIPAL lhlVESTIGATUR INSTITUTION s * ;\JA INITIAL FUNOINC YEA~ SMALL CONH A( r j:. Lt (lp,1r ~'T PPtlJF.'CT AT f INAL STAG~ Uf '"f:VHW NtH t\PPL lCAn f I 1i;;r ,f\V/\ Il. \RU: f IF ST SE:Cf!Nfl fJIWJI- TOll\L Yf:A~ VfAR TIUN BUDGET 8UDGET flUDGET (MUNTI-IS) us$ us$ us$ 04272 TASK FORCE PLANNING +OP~RATION BERGSTROM s. KARULINS~A INSTITUTE STOCKHOLM 72 155700 2,,eo 2!'1000 6() SW[l)EN TOTAL FOK SECTION "O. 022 TOTAL FOR TASK FORCE NO. 005 FINANCIAL tll3LIGATifJNS FnR 1972 : FINANCIAL OBLIGATIONS FrR 1973 SHALL CONTrACT All0T~ENT 1Q73 FINANCIAL OBLIGATIONS FOR 1972: FINANCIAL OBLIGATIONS FOR 1973 SMALL CONTRACT ALLUT~ENT 1973 25500 28000 28,,tOOD 5355'i0 42QO I '-) ~ 01/11/73 HR - EXPANDED PROGRAM - PROJECTS BY TASK FORCE AND SECTIU\ TASK FORCE: 013 IMMUNOLOGICAL METHODS PROJECT PRINCIPAL NO. PROJECT TITLE INVESTIGATOR INSTITUTION *04073 CONTRACEPTIVE STUDIES WITH GLASS L.E. DEP. Of ANATOMY ANTIBODY AGAINST ZONA SCHOOL Of MED.UNIV. PELL UC IDA CAL. SAN FRANCISCO u.s.A. *07773 EVAL.IHMUNIZATIONS FEM.BABOONS STEVENS V.C. DEPART OBSTETRICS & W.HAPTEN-COUPLED PLACENTAL LAC GYNAECOLOGY OHIO TOGEN AS A FERT.CONTROL METHOD STATE UNIV. COLUMBUS u.s.A. S07873 PREPARATION OF BABOON JOSIMOVICH J.B. SCHOOL OF MEDICINE PLACENTAL LACTOGEN UNIVERSITY OF PITTSB PITTSBURG PENS. u.s.A. 508073 IMMUNIZATION AGAINST ZONA GLASS L. E. OEP. Of ANATOMY PELLUCIDA SCHOOL OF MEO. UNIV. CAL. SAN FRANCISCO u.s.A. *508273 FCRMATIGN OF INFERTILITY BEHRMAN S.J. OEP.OF OBSTET.& GYN. BLOOD SERUM DISTRIBUTION BANK UNIVERSITY OF MICH. ANN ARBOR MICH. u.s.A. *08573 I MMUNOLOGJCAL FERTILITY REGUL. GOLDBERG E. NORTHWESTERN UNIY. BY LACTATE DEHYDROGENASE-X EVANSTON ILL. u.s.A. *08673 lMMUNOENZYMJC INVEST.INTO FERT MURTON o.e. STRANGEWAYS RESEARCH -SPERM ACROSOMAL HYALURONIDASE LAB. &TRYPSIN-LIKE NEUTR.PROTEINASE CAMBRIDGE UNITED KINGDOM *08973 IMMUNIZATION OF CHIMPANZEES JOSHI S.G. DEP.OBST.&GYN. MEO. AGAINST HCG-B COLL. UNION UNIY. ALBANY N.Y. u.s.A. 509073 ISOLATION ANO CHARACTERIZATION MENGE A.C. OEP.OF OBSTET.& GYN. Of THE SPERM-IMMOBILIZING ANTI UNIVERSITY Of HICH. GEN OF THE PRIMATE TESTIS ANN ARBOR MICH. u.s.A. s * !\IA INITIAL FUNDING YEAR 73 73 73 73 73 73 73 73 73 S~All CO~TQACT ALLOTMFNT PROJECT AT tlNAL STACE UF REVIEW N~·r APPLICABLE I NUT AVAILABLE FIRST StCON!J DURA- TOTAL YEAR YEAR TtON BUDGET BUDGET BUDGET I MONTHS) us$ us $ us $ 34700 34700 *NA* 12 49200 27200 22000 24 12600 12600 *NA* 12 1500 7500 *NA* 12 12000 12000 *NA* 12 48200 48200 *NA* 12 97600 41800 27100 36 24000 24000 *NA* 12 15000 15000 *NA* 12 ~ (II 01/11/73 HR - EXPANDED PROGRAM - PROJECTS BY TASK FORCE AND SECT ION TASK FORCE: 013 IHHUNOlOGICAL METHODS PROJECT PRINCIPAL NO. PROJECT TITLE INVESTIGATOR INSTITUTION 502973 ACQUISITION & STABILIZATION STEVENS V.C. DEPART OBSTETRICS+ BABOONS GYNAECOLOGY OHIO STATE UNIV COLUMBUS u.s.A. 05473 PREPARE PURIFY AND SHIP BETA DONINI P. INSTITUTO fARMACOLOG SUBUNIT Of HCG ICO ROME ITALY 05573 SYNTHESIS PEPTIOt FRAGMENTS Of NIALL H.O. HARVARD UNIVERSITY HUMAN GONAOOTROPHIN DEPARTMENT MEDICINE CAMBRIDGE MASS. u.s.A. 05673 EVALUATION ACTIVE IMMUNIZATION STEVENS V.C. DEPART OBSTETRICS+ WITH SUBUNITS+ FRAGMENTS OF GYNAECOLOGY OHIO HCG AS FERTILITY CONTROL METH STATE UNIV COLUMBUS u.s.A. 505973 SYNTHESIS HEXACOSAPEPTIDE SCHNEIDER C.H. INSTITUTE CLINICAL DERIVATIVES RELATED TO BET A IMMUNOLOGY SUBUNIT OF HCG BERN SWITZERLAND ---·· S : SHAlL CONTRACT ALLOTMENT * : PROJECT AT FINAL STAGE OF REVIEW NA: NOT APPLICABLE I NOT AVAILABLE INITIAL FIRST SECOND DURA- FUNDING TOTAL YEAR YEAR TION YEAR BUDGET BUDGET BUDGET I MONTHS) us$ us.$ us s 73 7500 7500 *NA* 12 73 20000 2th)00 *NA* 12 71 17?0!} 17200 *NA* 12 73 34700C 75000 136500 36 73 7300 7300 *NA* 12 TOTAL FOR TASK FORCE NO. 013 FINANCIAL OBLIGATIONS FOR 1972: FINANCIAL OBLIGATIONS FOR 1973: SMALL CONTRACT ALLOTMENT 1973 : 288100 61900 I I),) 0) 01/11/73 HR - EXPANDED PROGRAM - PROJECTS BY TASK FOMCE AND SECTION TASK FORCE: 031 INJECTABLE CONTRACEPTIVES PROJECT PRINCIPAL NO. PROJECT TITLE INVESTIGATUI< INSTITUTION *08873 DEVELOPMENT OF AN INJECTABLE DYNATECH COMP. OYNATECH COMPANY SUSTAINED RELEASE FERTILITY CAMBRIDGE MASS. CONTROL SYSTEM u.s.A. •S09397 STUDIES TO DEV.AND TEST AN INJ BECK L.R. OEP. Of OBSTET.&GYN. BIOOEGRAD. DEL.SYSTEM FOR SUST UNIV. OF ALABAMA RELEASE OF NORETHISTERONE BIRMINGHAM ALA. u.s.A. *09473 IMPROVED DELIVERY SYSTEM FOR ALZA CORP. ALZA CORPORATION A HORMONAL CONTRACEPTIVE PALO ALTO CAL. u.s.A. *11073 COMPARATIVE STUDIES OF MEDROXY 8 INSTITUTIONS CRCS AND PANEL PROGESTERONE ACETATE AND NOR- CENTRES ETHISTERONE OENANTHATE 506873 DEVELOPMENT Of NfN TYPE LONG TAUBERT H.O. J.W.GOETHE UNIVER- ACTING INJECTABLE STEROID SJTY PREPARATION FRANKFURT A.M. FED.REP.GERMANY S : SMALL CONTRACT ALLOTMENT * : PROJECT AT FINAL STAGE Of XEVIEW NA: NOT APPLICABLE I NOT AVAILABLE INITIAL F 11._5 T SECOND DURA- FUNDING TOTAL YEAR YEAR TION YEAk BUDGET BUDGET BUDGET I MONTHS) us$ us$ us $ 73 175000 139900 85100 21t 73 i4800 14800 *NA* 12 73 118400 118400 *NA* 12 73 37800 37800 *NA* 12 73 14950 14950 *NA* 12 TOTAL FOR TASK FORCE NO. 031 FINANCIAL OBLIGATIONS FOR 1972: FINANCIAL OBLIGATIONS FOR 1973: SMALL CONTRACT ALLOTMENT 1973 : 246100 29750 .., ..., 01/11/73 HR - EXPANDED PROGRAM - PROJECTS BY TASK FORCE AND SECTION s : SMALL CONTRACT ALLOTMENT TASK FORCE: 006 SEQUF.LAf Of INDUCED Af\nf'.TION * : PROJECT AT FINAL STAGE Of REVIEW NA: NOT APPLICABLE I NOT AVAILABLE SECTION: 026 SOMATIC COMPLICATIONS ANO SHWELAE INITIAL FIRST PROJECT PRINCIPAL FUNDING TOTAL YEAR NO. PROJECT TITLE INVESTIGATOR INSTITUTION YEAR BUOGfT BUDGET us$ us$ 03372 ANALYSIS LATE SEQUELAE INDUCED DAVIES A. HEBREW UNIVERSITY 72 5600 5600 ABORTION HAOASSAH MEDICAL SCH OOL JERUSALEM ISRAEL 04372 SHORT-TERM COMPLICATIONS CHENG M.C. DEPARTMENT OBSTETRIC 72 50800 50800 I NOUCED ABORTION &GYN. KANOANG KERB. HOSPITAL SINGAPORE SINGAPIJRE 04472 SHORT-TERM COMPLICATIONS OF ANDOLSEK L. FAMILY PLANNING 72 65700 40700 I NOUCED ABORT ION INSTITUTE tJUBLJANA YUGOSLAVIA 12073 LONG TERM COMPLICATIONS 5 CENTRES NtWCASTLE-COPENHAG.- 73 *NA* 180000 INDUCED ABORTION LJUBLJANA-SEOUL- STOCKHOLM 12173 IMMEDIATE COMPLICATIONS t MULTIPLE CENTR. SEVERAL CENTRES IN 73 *NA* 25000 ABORTION/STERILIZATION- INDIA COMBINED INTERVAL TOTAL FOR SECTION NO. 026 FINANCIAL OBLIGATIONS FOR 1972: FINANCIAL OBLIGATIONS FOR 1973 SMALL CONTRACT ALLOTMENT 1973 . . SECOND YEAR BUDGET us$ *NA* *NA* 25000 *NA* *NA* 97100 230000 DURA- TION ( MONTHS) 12 12 18 Zlt 36 w OD 01/11/73 HR - EXPANDED PROGRAM - PROJECTS BY TASK FORCE AND SECTION S : SMALL CONTRACT ALLOT~ENT TASK FORCE: 006 SEQUEL AE OF I NOUCED ABURT ION SECTION: 029 COORDINATION * : PROJECT AT FINAL STAGE OF REVIEW NA: NOT APPLICABLE I NOT AVAILA8LE PROJECT NO. PROJECT TITLE 73004 COORDINATION 73008 PREPARATION OF RECORD FURMS & CODES-COMP.STUDY INDUCED ABORT AND TUBAL STERILIZATION INITIAL FIRST PRINCIPAL FUNDING TOTAL YEAR INVESTIGATOR INSTITUTION YEAR BUDGET BUDGET us$ us s EDSTROM K. KAROLINSKA HOSPITAL 73 1800 1800 STOCKHOLM SWEDEN TIETZF. S.L. BIOMEDICAL DIVISION n '1500 1500 POPULATION COUNCIL NEW YORK N.Y. u.s.A. TOTAL FOR SECTION ND. 029 FINANCIAL OBLIGATIONS FOR 1972: TOTAL FOR TASK FORCE NO. 006 FINANCIAL OBLIGATIONS FOR 1973: SMALL CONTR4CT ALLOTMENT 1973 : FINANCIAL OBLIGATIONS FOR 1972: FINANCIAL OBLIGATIONS FOR 1973: SMALL CONTRACT ALLOTMENT 1973 . . SECOND YEAR BUDGET us.$ *NA* *NA* 3300 97100 233300 DURA- TION ( MONTHS) 12 12 !!I:> co 01/11/73 HR - EXPANDED PROGRAM - PROJECTS BY TASK FORCE ANO SECTION TASK FORCE: 016 ACCEPT. FERT. REG. METHODS PROJECT PR INC I PAl. NO. PROJECT TITLE INVESTIGATOR INSTITUTION 12473 WORKING GROUP FOR THE DEVELOP- MARSELLA A.J. UNIVERSITY Of MENT OF METHODOLOGICAL HAWAII INSUUMENTS HONOLULU HAW. u.s.A. 12573 REVIEW OF EXISTING flACK K.W. DUKE UNI VERS ITV KAP STUDIES DURHAM N.C. u.s.A. 12673 PILOT STUDY YO DEVELOP RE- HARDING J. POLICY RESEARCH ANO SEARCH INSTRUMENTS FOR PLANNING GROUP ASSESSING ACCEPTABILITY BERKELEY CAL. u.s.A. 12773 COORDINATION: INDIGENOUS NEWMAN L. HOOPER FOUNDATION FERTILITY REGULATING METHODS UNIV.OF CALIFORNIA BERKELEY CAL. u.s.A. 12873 OEV.&PRETEST: METHODOLOGICAL 3 CENTRES COLLAB.CENTRES IN INSTR.FOR ASSESSING PERCEPT. KOREA-PHILLIPINES- Of FERT. KEGULATING METHODS USA (HAWAIU 73007 COORDINATION MARSHALL J. f, CAROLINA POP. CENTEK UNIV. NURTH CAROLINA CHAPEL HILL u.s.A. 73009 ANNOTATED BIBLIOGRAPHIC REVIEW SHIPMAN P. CAROLINA POP. CENTER ON THE ACCEPTABILITY OF UNIV. NORTH CAROLINA FERTILITY REGULATING METHODS CHAPEL HILL u.s.A. s * NA INITIAL FUNDING YEAR 73 73 73 73 73 73 73 SMALL CONT~ACT ALL~TMfhT PROJECT AT FINAL STAGE: UF REVIfW NOT APPLICABLE I NOT AVAILABLE FIRST Sf.:CONO DURA- TOTAL YEAH YfAR TlfJN BUDGET BUDGET BUDGET ( MOI\THS) us$ us$ us$ 7200 1200 4000 24 15700 15700 *NA* 12 16')1)() 16000 * NA * 0.5 43500 14500 14000 3o 24000 24000 *NA* 12 9570 957C *NA* 05 13300 13300 *NA* 12 TOTAL FOR TA.SK fllRCE NO. 1)16 fl!'.ANClAL !Jt\l lG1iTIUNS ,-:.d,: 197Z : FINANCIAL !1FllIGHliJNS fC~~ 1973 : 96?7() SMALL LONT~ACT ALLUlMfNT 1973 ~ - 31 - 2. CLINICAL RESEARCH CENTRES (CRCs) Institution Departments of Obstetrics and Gynaecology and of Chemical Pathology, Faculty of Medicine, University of Ibadan, Ibadan, Nigeria Women's Hospital, Los Angeles County, University of Southern California Medical Center, Los Angeles, California, United States of America National Institute of Nutrition, Mexico City, Mexico Maternidade Climerio Oliveira, Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Bahia, Brazil Hospital R. Barros Luco-Trudeau, Santiago, Chile Family Planning Institute, Ljubljana, Yugoslavia Department of Obstetrics and Gynaecology, Medical School, University of Szeged, Szeged, Hungary Department of Obstetrics and Gynaecology, Academic Hospital, University of Utrecht, Utrecht, Netherlands Hopital St Pierre, Universite Libre de Bruxelles, Brussels, Belgium Department for Gynaecological Endocrinology, Klinikum Steglitz, Free University of Berlin, Berlin Institute for Research in Reproduction jointly with the G.s. Seth Medical College and KEM Hospital, Bombay, India The Postgraduate Institute of Medical Education and Research, Chandigarh, India Family Planning Research Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand Reproductive Biology Centre, Department of Obstetrics and Gynaecology, College of Medicine, University of the Philippines, Manila, Philippines Programme Development Support (US$) recommended for second year 33 400 25 OOO 23 800 29 400 30 OOO 30 OOO 33 OOO 27 OOO 36 OOO 43 OOO 50 OOO 26 300 30 OOO 5 OOO - 32 - Institution University Department of Obstetrics and Gynaecology, Kandang Kerbau Hospital for Women, Singapore Queen Elizabeth II Research Institute for Mothers and Infants, University of Sydney, Sydney, Australia Total Programme Development Support to: Shatby Maternity Hospital, Alexandria University, Alexandria, Arab Republic of Egyptl 1 Seoul National University, Seoul, Korea Site visits and duty travel Clinical trials not covered in task force allotment Data Processing Staff Meeting of CRC Directors Adjustment of CRC Financial Year Total 1 . . . Designation awaiting Government approval. Programme Development Support (US$) recommended for second year 30 OOO 42 OOO 493 900 30 100 23 OOO 20 OOO 30 OOO 60 OOO 23 OOO 20 OOO 700 OOO - 33 - 3. RESEARCH AND TRAINING CENTRES (RTCs) Institution All India Institute of Medical Sciences, New Delhi All Union Scientific Institute of Obstetrics and Gynaecology, Moscow Karolinska Institute, Stockholm "Three Nations Programme" Buenos Aires, Montevideo, Santiago Meeting RTC Directors anci Principal Investigators Duty Travel Site visits, consultations Total Programme Development Support (US$) Approved for second year 260 OOO llO OOO 446 OOO 170 OOO 25 OOO 9 OOO 1 020 OOO - 34 - 4. RESEARCH TRAINING 4.1 Support to Courses Seminar on Clinical Trial Methodology for Fertility, Regulating Agents, Chulalongkorn Hospital and Medical School, Bangkok, Thailand 4.2 Individual Research Training Grants RESEARCH TRAINING GRANTS AWARDED BY THE EXPANDED PROGRAMME SINCE OCTOBER 1972 AND AS OF 25 OCI'OBER 1973 Name and Home Institution Miss A. R. Aedo Departamento de Fisiologia y Biofisica Facultad de Medicina Universidad de Chile Santiago Chile Dr K. E. B. Ahren Department of Physiology University of Gtlteborg Gtlteborg Sweden Dr G. Archimaut Centro Latinoamericano de Perinatologia y Desarrollo Humano Hospital de Clinicas Montevideo Uruguay Dr A. E. Ayuy University of Chile Santiago Chile Host Institution WHO RTC Stockholm Sweden Purpose of Grant Radioimrnunoassay techniques for steroids and studies of steroid biogenetic pathways in testicular, ovarian and placental preparations 1. Weizmann Institute Mechanism of action Rehovot of gonadotrophins Israel 2. Tel-Hashomer Government Hospital Tel-Hashomer Israel WHO RTC Latin America 1. Department of Pharmacology University of Alberta Edmonton Canada 2. Department of Obstetrics and Gynaecology University of Texas, Health Science Center San Antonio Texas, United States of America 1973 Latin American Training Course on Reproductive Biology Human oviducts, in vitro and in vivo methodology us$ 20 OOO 250 OOO Period of Grant 1 year 3 months 21 weeks 1 year Name and Home Institution Dr A. Bhattacharyya Department of Biochemistry University of Calcutta Calcutta India Dr A. J. Castro-Vazquez ILAFIR l San Miguel (PBA) Argentina Dr w. P. Collins Department of Obstetrics and Gynaecology King's College Hospital Medical School London United Kingdom Dr B. Daunter University of Southampton Southampton United Kingdom Dr A. R. Dujovne Department of Bioch~mistry Universidad "J.A. MAZA" Mendoza Argentina Dr J. Espinosa-Campos Department of Reproductive Biology Insti tuto Nacional de la- Nutricion Mexico D.F. Mexico - 35 - Host Institution Visits to four institutions in the United States of America University of Texas Dallas Texas, United States of America Weizmann Institute of Science Rehovot Israel Visits to three institutions in the United States of America WHO RTC La tin America University of Pittsburgh Pittsburgh Pennsylvania United States of America Purpose of Grant Spermatozoal enzymes and fertilization Measurement of gonadotrophins and preparation of hypo- thalamic extracts Preparation of anti- sera to steroids and prostaglandins Techniques in investigating cervi- cal .mucus enzyme systems and semen protease inhibitor systems 1973 Latin American Training Course on Reproductive Biology Physiology of reproduction in non~human primates 1 Instituto Latinoamericano de Fisiologia de la Reproduccion. Period of Grant 1 year 1 year 3 months 3 months 2 years 1 year Name and Home Institution Dr M.A. Garcia-Hjarles Universidad Peruana Cayetano Heredia Instituto de Investigaciones de la Altura Lima Peru Dr G. A. Giussi Centra Latinoamericano de Perinatologia y Desarrollo Humano Hospital de Clinicas Montevideo Uruguay - 36 - Host Institution WHO RTC Latin America WHO RTC Latin America Dr Gonzalez de Vargas WHO RTC Instituto de Fisiologia Latin America Facultad de Ciencias Medicas Universidad Nacional de Cordoba Cordoba Argentina Dr R. M.A. Guerrero Head, Steroid Research and Histology Laboratories Section on Fertility Research Department of Obstetrics and Gynaecology Universidad de Chile Hospital J. J. Aguirre Santiago Chile Mr A. J. !song University of Ibadan Ibadan Nigeria Dr H. Utbbert Abt. fur Gynakalogische Endokrinologie Klinikum Steglitz Berlin Fed. Rep. of Germany Dr F. M. Martin Psycho-Endocrine Unit Department of Psychiatry University College Dublin Ireland WHO RTC Stockholm Sweden Visits to three institutions in the United Kingdom Massachusetts General Hospital Boston United States of America University of Helsinki Helsinki Finland Purpose of Grant 1973 Latin American Training Course on Reproductive Biology 1973 Latin American Training Course on Reproductive Biology 1973 Latin American Training Course on Reproductive Biology Radioimmunoassay methods for the simultaneous determination of progesterone, testo- sterone, estradiol, pregnenolone, estrone and dehydroepiandro- sterone Maintenance, repair and design principles of nuclear electronic and other analytical laboratory instruments Period of Grant 2 years 21 weeks 2 years 1 year 6 months Isolation, purifica- 6 months tion and assay methods of steroid enzymes Metabolism of 1 year progesterone and synthetic progestogens in normal subjects and in liver disease Name and Home Institution Dr J, Martin ILAFIR1 San Miguel (PBA) Argentina Dr D. A, Olatunbosun Department of Chemical Pathology University of Ibadan Ibadan Nigeria Dr P.R. K. Reddy Department of Zoology University of Delhi Delhi India Dr E. Samojlik Department of Clinical Endocrinology Medical Academy Warsaw Poland Dru. D. Schwartz Abt, Gyn, Endokrin Klinikum Steglitz Berlin Fed, Rep, of Germany Dr P, L, Sharma Head, Department of Pharmacology Postgraduate Institute of Medical Education and Research Chandigarh India Dr N, A. Spaltro Centro de Educacion Medica e Investigaciones Clinicas Buenos Aires Argentina - 37 - Host Institution WHO RTC Latin America WHO RTC Stockholm Sweden Harvard University School of Medicine Boston Massachusetts United States of America University of California Los Angeles California United States of America Visits to five institutions in the United States of America Purpose of Grant 1973 Latin American Training Course on Reproductive Biology Mineral metabolism in reproduction in relation to contra- ceptive devices Endocrinology of reproduction FSH, LH and estrogens in urine and plasma of women with hormonal disorders Radioimmunoassay of steroid hormones 1. Postgraduate Clinical pharmacology Medical School Hammersmith Hospital London United Kingdom 2, University of Rochester Rochester N. Y,, United States of America WHO RTC Latin America 1973 Latin American Training Course on Reproductive Biology 1 Instituto Latinoamericano de Fisiologia de la Reproduccion. Period of Grant 2 years 3 months 1 year 6 months 1 year 3 months 2 years - 38 - 5. GrHER PROGRAMMES 5.1 Small Research C.ontracts Programme Investigator 1. Re-entry Contracts Dr J. A. Aragon Dr M.A. Cannata Dr R. G. V. Lo Castro Montorzi Dr Wan Kyoo Cho Dr W. Ribeiro Dr Puttipongse Varabudhi Institution Departamento de Morfologia y Unidad de Fisiologia de la Reproduction Universidad del Valle Cali, Colombia Neurobiology Institute Buenos Aires ' Argentina Instituto de Histologia y Embryo- logia Universidad Nacional de Cuyo Mendoza, Argentina Department of Obste- trics and Gynae- cology Seoul National University Seoul, Korea Centre for Reproduc- tive Biology Federal University of Juiz de Fora Juiz de Fora, Brazil Department of Biology Chulalongkorn University Bangkok, Thailand Project Prostaglandin and Oxytocin Action on the Mouse Blood- Testis Barrier The Neural Lobe as a Source of an Adenohypo- physial Releasing Factor Transporting Properties of Nonciliated Cells in the Human Fallopian Tube Role of Cyclic Nucleotides and Prostaglandins in Ovum Maturation Standardization of the Radio- immunoassay for Measurements of Ovarian Steroids; Base- line Studies of Ovarian Steroids in Plasma during the Menstrual Cycles of Brazilian Women Observation of Ovulating Cycle and Determination of Blood FSH, LH, Prolactin and Ovarian Steroids of Female Crab-eating Monkeys (Macaca fascicularis) Budget (US$) 7 500 2 300 3 OOO 7 500 7 500 4 300 - 39 - Investigator Institution 2. Task Force Related Contracts Dr c. E. Adams Dr L. R. Beck Dr s. J. Behrman Dr L. Bengtsson Dr R. Eliasson Dr F. s. French Dr L. E. Glass Dr C. E. Hamner Agricultural Research Council Unit of Reproductive Physiology and Bio- chemistry Cambridge, United Kingdom Department of Obste- trics and Gynaeco- logy University of Alabama Birmingham, Alabama United States of America University of Michigan Ann Arbor Michigan, United States of America University of Lund Lund, Sweden Reproductive Physio- logy Unit Karolinska Institutet Stockholm, Sweden Laboratory for Repro- ductive Biology University of North Carolina Chapel Hill, North Carolina, United States of America Department of Anatomy University of California San Francisco California, United States of America Department of Obste- trics and Gynae- cology University of Virginia Charlottesville, Virginia, United States of America Project Evaluation of Egg Develop- ment and Viability under Different Endocrine Condi- tions in the Rabbit Studies to Develop and Test an Injectable, Biodegra- dable Delivery System for the Sustained Release of Norethisterone Formation of Infertility Blood Serum Distribution Bank Effects of Glypressin on Myometrial Activity in the Non-pregnant Woman Identification of Functional Parameters in Human Spermatozoa Related to Male Fertility Characterization of Specific Androgen Carrier and Receptor Proteins Immunization against Zona Pellucida Development of Rabbit Embryos during In Vitro Incubation Budget (US$) 9 400 14 800 12 OOO 7 500 15 OOO 4 500 7 500 6 200 Investigator Dr w. R. Jones Dr J.B. Josimovich Mrs. Kitrilakis Dr A. J. Margolis Dr P. v.·Maynard Dr A. c. Menge Dr R. s. Neuwirth Dr O. Nil &son - 40 - Institution Department of Obste- trics and Gynae- cology University of Sydney Sydney, Australia University of Pittsburgh School of Medicine Pittsburgh, Pa., United States of America Teena Corporation Emeryville California, United States of America Department of Obste- trics and Gynae- cology University of California San Francisco California, United States of America Tenovus Institute for Cancer Research Welsh National School of Medicine Cardiff, United Kingdom University of Michigan Ann Arbor Michigan, United States of America College of Physicians and Surgeons of Colombia University New York, United States of America Institute of Human Anatomy University of Uppsala Uppsala, Sweden Project Investigation of Possible Luteolytic Role of Intra- uterine PGF2~ in the Non- Pregnant Human Female Preparation of Baboon Placental Lactogen Fabrication of Experimental Tubal Occluding Plugs 1. Evaluation of Micro- porous Interface Coated Fallopian Tube Plugs in Animals 2. Evaluation of Micro- porous Interface Coated Fallopian Tt.'be Plugs in Animals: Phase II Copper Intrauterine Contra- ception - X-ray Micro- analysis of Human Sperm Cells Isolation and Characteriza- tion of the Sperm- Immobilizing Antigen of the Primate Testis Evaluation of Reversible Tubal Occluding Devices Heterologous Implantation In Vitro Budget (US$) 4 200 12 600 7 450 3 OOO 6 100 5 500 15 OOO 7 400 3 350 Irivestigator Dr E. s. Nuwayser Dr R. M. Richart Dr c. H. Schneider Dr L. Speroff Dr V. c. Stevens Dr H .• D. Taubert Dr L. Terenius 3. Other Small Contracts Dr D. N. De Carli - 41 - Institution Abcor Incorporated Cambridge Massachusetts, United States of America College of Physicians ' - an~ Su~geons of Colombia.University New York, United States of America . Institute for Clinical Immunology Bern; Switzerland Department of Obste- trics and Gynae- cology Yale- University. School of Medicine New Haven,· Connecticut United States of America Ohio State University Research Foundation Colombus, Ohio, United States of America Division of Gynae- cologic Endocrinology J. W. Goethe University Frankfurt am Main Federal Republic of Germany Departmeqt of Medical Pharmacology Uppsala University Uppsala, Sweden Universidad del Salvador San Miguel Argentina Project Development of a Rever- sible I:ntratubal Occlu- ding Device Evaluation of Reversible Tubal Occluding Device Synthesis· of Hexaco- sapeptide Derivatives Related to the Beta sub- unit of Human Chorionic Gonadotrophin The Effect of the IUD on Estradoil Progesterone, and Prostaglandin Levels in Endometrium Acquisition and Stabiliza- tion of Baboons (Papio Anubis) Development of a New Type of Long Acting Injectable Steroid Preparation for Contraceptive Use Antiprogestational Agents Histaminic Control of the Effects of Estrogen and Gestagens in the Uterus Budget (US$) 7 480 7 400 7 300 6 650 7 500 14 950 7 500 7 500 Investigator Dr M. Chulavatnatol Dr E. P. Garcia Dr A. N. Ferrari - 42 - Institution Mahidol University Bangkok Thailand Universidad del Salvador San Miguel Argentina Federal University of Rio Grande do Sul Porto Alegre Brazil Estimated Expenditure Project Role of Cyclic AMP in the Survival and Motility of Human Spermatozoa Interaction of Estrogens and Catecholamines in the Uterus: a Possible Target for Fertility Control Colour Changes in Cervical Mucus in Relation to Ovulation Budget (US$) 5 OOO 4 OOO 7 500 Estimated Additional Funds Required Estimated Total Expenditure for 1973 (Oct. 73) (Oct.-Dec.) 256 380 43 620 300 OOO 5.2 Small Supplies Programme Institution 1. 2. 3. 4. 5. 6. Department of Chemical Pathology University of Ibadan Ibadan, Nigeria Department of Obstetrics and Gynaecology Ghana Medical School Accra, Ghana Institute of Research in Biology of Reproduction Pelotas, Brazil Center for Biology of Reproduction Federal University of Juiz de Fora Juiz de Fora, Brazil Department of Obstetrics and Gynaecology Federal University of Bahia Salvador - Bahia, Brazil Department of Obstetrics and Gynaecology University of Rio Grande do Sul Porto Alegre Brazil Estimated 1973 Expenditure US$ 1 OOO 500 525 500 1 OOO 500 - 43 - Institution 7. a. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. Servicia de Obstetricia y Ginecologie Hospital R. Barros Luco-Trudeau Santiago, Chile Department of Physiology Catholic University of Chile Santiago, Chile Department of Obstetrics and Gynaecology Universidad del Valle Cali, Colombia Unit of Obstetrical Physiology Maternity Hospital San Salvador, El Salvador Instituto de Investigaciones de la Altura Universidad Puruano Cayetano Heredia Lima, Peru Laboratory for Investigation of Human Reproduction Hospital Pereira Rossell Montevideo, Uruguay Department of Obstetrics and Gynaecology University of Barcelona Barcelona, Spain Department of Anatomy University Medical School Pees, Hungary Department of Physiology University Medical School Pees, Hungary Department of Obstetrics and Gynaecology University Medical School Szeged, Hungary Gynaecology Clinic No. 2 Medical University of Budapest Budapest, Hungary Institute of Experimental Medicine Hungarian Academy of Sciences Budapest, Hungary Department of Obstetrics and Gynaecology Medical University of Debrecen Debrecen, Hungary Estimated 1973 Expenditure US$ 360 1 OOO 1 125 500 1 100 1 OOO 500 1 225 1 OOO 1 450 1 OOO 500 1 OOO - 44 - Institution 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. Institute of Animal Physiology and Nutrition Jablonna, Poland Department of Obstetrics and Gynaecology Medical School of Warsaw Warsaw, Poland Department of Embryology University of Warsaw Warsaw, Poland lst Clinic of Obstetrics and Gynaecology Medical Academy of Warsaw Warsaw, Poland Department of Clinical Endocrinology Medical Academy of Warsaw Warsaw, Poland Institute of Experimental Pathology and Therapy Sukhumi, USSR Institute of Obstetrics and Gynaecology Leningrad, USSR Institute of Experimental Endocrinology and Hormone Chemistry Moscow, USSR Laboratory of Research on Experimental Embryology USSR Ministry of Health Moscow, USSR University Clinic of Obstetrics and Gynaecology Family Planning Institute Ljubljana, Yugoslavia Department of Obstetrics and Gynaecology University of Novi Sad Novi Sad, Yugoslavia Department of Biology University of Zagreb Zagreb, Yugoslavia Institute of Mother and Child Zagreb, Yugoslavia Department of Obstetrics and Gynaecology University of Zagreb Zagreb, Yugoslavia Estimated 1973 Expenditure US$ 425 475 400 500 l OOO 500 2 OOO l 500 100 l OOO 500 500 500 500 - 45 - Institution 34. Department of Obstetrics and Gynaecology Assiut University 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. Cairo, Arab Republic of Egypt Department of Obstetrics and Gynaecology Shatby Maternity Hospital Alexandria, Arab Republic of Egypt Department of Obstetrics and Gynaecology Cairo University Kasr El-Aini Hospital Cairo, Arab Republic of Egypt School of Pharmacy Hebrew University Jerusalem, Israel Central Laboratories Pakistan AEC Karachi, Pakistan Department of Physiology Raja Peary Mohan College West Bengal, India Department of Obstetrics and Gynaecology Postgraduate Institute Chandigarh, India Department of Experimental Medicines Postgraduate Institute Chandigarh, India Department of Endocrinology Postgraduate Institute Chandigarh, India Department of Pharmacology Postgraduate Institute Chandigarh, India Department of Biochemistry Postgraduate Institute Chandigarh, India Department of Pathology Haematology Section Postgraduate Institute Chandigarh, India Department of Biochemistry University College of Science Calcutta, India Estimated 1973 Expenditure US$ 450 200 225 325 775 525 325 475 425 500 625 250 1 OOO - 46 - Institution 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. Division of Endocrinology Central Drug Research Institute Lucknow, India Department of Zoology University of Delhi Delhi, India Department of Obstetrics and Gynaecology Seth G.S. Medical College Bombay, India Institute of Research in Reproduction Indian Council for Medical Research Bombay, India Family Planning Hospital Seth G.S. Medical College Bombay, India Department of Pharmacology Seth G.S. Medical College Bombay, India Department of Zoology University of Rajasthan Jaipur, India National Institute of Family Planning New Delhi, India Endocrinology Laboratory India Institute of Science Bangalore, India Department of Zoology University of Agricultural Sciences Bangalore, India Department of Zoology University of Benares Varanasi, India Department of Obstetrics and Gynaecology Ramathibodi Hospital Bangkok, Thailand Department of Obstetrics and Gynaecology Family Planning Research Unit Mahidol University Bangkok, Thailand Estimated 1973 Expenditure US$ 1 500 2 OOO 500 550 500 500 500 1 OOO 1 OOO 250 500 1 OOO 1 OOO - 47 - Institution 60. 61. 62. 63. 64. 65. 66. Department of Obstetrics and Gynaecology Reproductive Physiology Laboratory Catholic Medical Center Seoul, Korea College of Medicine Seoul National University Seoul, Korea Center for Population and Family Planning Yonsii University Seoul, Korea Department of Obstetrics and Gynaecology University of the Philippines Manila, Philippines Department of Obstetrics and Gynaecology University of Singapore Singapore Department of Obstetrics and Gynaecology Kandang Kerbau Hospital for Women Singapore Zoological Institute University of Tokyo Tokyo, Japan Total 5.3 1 Pilot Journal Subscription Project (1973) - Small Supplies Programme Institution 1. 2. 3. WHO Clinical Research Centre Department of Obstetrics and Gynaecology University of Ibadan Ibadan, Nigeria WHO Clinical Research Centre Department of Obstetrics and Gynaecology Universidad Federal da Bahia Salvador, Brazil WHO Clinical Research Centre Department of Obstetrics and Gynaecology Hospital Barros Luco-Trudeau Santiago, Chile Estimated 1973 Expenditure US$ us $ 500 500 1 200 1 OOO 250 1 OOO 525 47 560 1973 Expenditure US$ 350 300 300 1 Costs of airmail subscription to one or more of the following three journals: (a) Bibliography of Family Planning and Population (b) Bibliography of Reproduction (c) Current Contents - Life Sciences. - 48 - Institution 4. 5. 6. 7. 8. 9. 10. 11. 12. WHO Clinical Research Centre Department of Obstetrics and Gynaecology University Medical School Szeged, Hungary Institute of Experimental Endocrinology and Hormone Chemistry Moscow, USSR WHO Clinical Research Centre Department of Obstetrics and Gynaecology KEM Hospital Bombay, India WHO Clinical Research Centre Institute for Research in Reproduction Indian Council for Medical Research Bombay, India WHO Clinical Research Centre Department of Obstetrics and Gynaecology Postgraduate Institute Chandigarh, India WHO Research and Training Centre All India Institute of Medical Sciences New Delhi, India WHO Clinical Research Centre Department of Obstetrics and Gynaecology Family Planning Research Unit Siriraj Hospital - Mahidol University Bangkok, Thailand WHO Clinical Research Centre Institute of Reproductive Biology College of Medicine Seoul National University Seoul, Korea WHO Clinical Research Centre Department of Obstetrics and Gynaecology Reproductive Biology Centre Philippine College of Medicine Manila, Philippines Total !ill Expenditure US$ 20 260 350 350 110 350 350 350 350 us $ 3 440 - 49 - 5.4 Seminars, Workshops, Publications 5.5 Seminars and Workshops Symposium on Chromosomal Errors in Relation to Reproductive Failure (Paris, September 1973) III European Anatomy Congress - Symposium on Control Processes in Reproduction (Manchester, United Kingdom, September 1973) Symposium on Transport, Survival and Fertilizing Ability of Spermatozoa (Nouzilly, France, November 1973) International Symposium on Physiologic and Genetic Aspects of Reproduction (Bahia, Brazil, December 1973) WHO Symposium on Recent Advances in Fertility Control (Chandigarh, India, January 1974) Publications "Cervical Mucus in Human Reproduction" List of "WHO Publications on Human Reproduction and Related Subjects" Consultant Services to Institutions Consultant to the Department of Obstetrics and Gynaecology Chulalongkorn Hospital, Bangkok, Thailand Consultant to Centro de Biologia da Reproducao Federal University of Juiz de Fora, Brazil us$ 5 OOO 1 OOO 5 500 15 OOO 40 OOO 8 500 l OOO us$ 66 500 9 500 76 OOO us$ 25 OOO 15 OOO 40 OOO 6. PROGRAMME OPERATIONS 6.1 Meetings Advisory Group June 1973 October 1973 Review Group May 1973 November 1973 - 50 - Meetings of Interested Agencies, November 1973 6.2 Headquarters Staff and Consultants Staff Consultants Temporary staff us$ 17 OOO 21 OOO 13 OOO 13 OOO us$ 38 OOO 26 OOO 6 OOO 70 OOO us$ 350 OOO 100 OOO 25 OOO 475 OOO - 51 - APPENDIX B November, 1973 1. ADVISORY GROUP - 52 - ·Professor B. Kwaku Adadevoh Department of Chemical Pathology University of Ibadan Ibadan Nigeria Professor L. Andol§ek Klinicne Bolnice Ljubljana Ljubljana Yugoslavia Professeur E. E. Baulieu Departement de Chimie Biologique Faculte de Medecine de Bicetre Paris France Professor ,J. C. Caldwell Research School of Social Sciences Australian National University Canberra Australia Dr P.A. Corfman Center for Population Research National Institute of Child Health and Human Development Bethesda United States of America Professor E. M. Coutinho Maternidade Climerio de Oliveira Universidade Federal da Bahia Salvador Brazil Professor A. B. Kar Division of Endocrinology Central Drug Research Institute Lucknow India Dr Anne McLaren Institute of Animal Genetics Edinburgh Scotland United Kingdom Professor W. Paul Department of Obstetrics and Gynaecology Toronto Western Hospital Toronto Canada - 53 - Dr B. Rexed (Chairman) Socialstyrelsen .Stockholm Sweden Dr S. Segal Biomedical Division The Population Council New York United States of America Professor N. A. Yudaev Institute of Experimental Endocrinology and Hormone Chemistry Academy of Medical Sciences of the USSR Moscow USSR 2. REVIEW GROUP: PARTICIPATING SCIENTISTS AND REFEREES Dr C. R. Austin Physiological Laboratory Cambridge University Cambridge United Kingdom Dr J.M. Bedford Cornell Medical College New York United States of America Dr B. R. Bloom Albert Einstein College of Medicine Bronx New York United States of America Dr U. Borell (Co-Chairman) Karolinska Hospital Stockholm Sweden Dr Y. Clermont Department of Anatomy McGill University Montreal Canada Dr P. K. Devi Department of Obstetrics and Gynaecology Postgraduate Institute of Medical Education and Research Chandigarh India - 54 - Dr C. Gual Department of Reproductive Biology .Instituto Nacional de la Nutricion Mexico D.F. Dr S. Lieberman International Institute for Human Reproduction Columbia University New York United States of America Dr M. B. Lipsett Reproductive Biology National Institute of Child Health and Human Development Bethesda Maryland United States of America Dr D.R. Mishell (Co-Chairman) Department of Obstetrics and Gynaecology University of Southern California Los Angeles California United States of America Dr N. A. Mitchison Department of Zoology University College London London United Kingdom Dr R. Prado Clinica Obstetrica Universitaria Santiago Chile Dr R. Shearman Department of Obstetrics and Gynaecology University of Sydney Sydney Australia Dr M. P. Vessey Department of the Regius Professor of Medicine Radcliffe Infirmary Oxford United Kingdom Dr O. Westphal Max Planck Institute for Immunobiology Freiburg-im-Breisgau Federal Republic of Germany - 55 - The following have acted as referees: -Dr E. J. Corey Department of Chemistry Harvard University Cambridge Massachusetts United States of America Dr J. Fried The Bentley Laboratory for Cancer Research Chicago United States of America Dr R, Paoletti Istituto di Farmacologia Universita di Milano Milan Italy - 56 - STAFF IN THE HUMAN REPRODUCTION UNIT AS AT NOVEMBER 1973 Name Miss s. Allen Mr R. N. Bailey Dr M. Belsey 1 Dr R. Borth Mr B. Ericson Dr M. Harper Mr P. Heiner Dr E. Johannisson 1 Dr A. Kessler 1 Dr A. Leader Dr J. Marshall 2 Miss L. McGill Mrs M. L. Monnier Mr E. Rljed Dr P. Rowe Dr H. Salomon Dr R. Shearman Mr J. Spieler 1 Mrs C. C. Standley Mrs M.-L. Van de Velde Dr R. Wilson SECRETARIAL STAFF 1. Regular Programme and UNFPA Activities Mrs L. Furnari Miss M. Robson Miss H. Woodward 2. Expanded Programme Mrs A. Bianchi Miss J. Jones Mrs C. Leckenby Miss A. McEntee Miss A. Porter Miss D. St. Pierre (Temporary) Position Administrative Assistant Technical Officer Medical Officer (20%) Scientist Programmer/Analyst Scientist Programmer/Analyst Medical Officer (0%) Chief Medical Officer (70%) Consultant/Medical Officer (until June 1974) Social Scientist Technical Assistant Statistical Clerk Administrative Officer Medical Officer Technical Officer Consultant/Medical Officer (until December 1973) Technical Officer Scientist (40%) Technical Assistant Consultant/Medical Officer (until June 1974) 1 Denotes staff recruited under the WHO Regular Budget; percentages indicate approximate time spent on Expanded Programme activities. 2 Selected by WHO, scheduled to start 1 January 1974. Date 1972 27 November - 1 December 4-5 December 4-6 December 4-8 December 6-8 December 7-8 December 11-13 December 18-20 December Date 1973 9-11 January 10-12 January 13-14 January 17-20 January 22-26 January 22 January - 1 February 23 January 9 February 26-30 January 30-31 January 30 January - 4 February 31 January - 2 February - 57 - WHO EXPANDED PROGRAMME OF RESEARCH, DEVELOPMENT AND RESEARCH TRAINING IN HUMAN REPRODUCTION Major Activities, November 1972 - October 1973 Activity (Meeting at headquarters, Geneva, unless indicated otherwise) Advisory Group 3 Staff consultation on progesterone receptors, Paris Staff participation in discussions on acceptability of fertility regulating agents with Swedish Pugwash Group, Stockholm Staff consultation with industry on vaginal rings, Seattle, Palo Alto Staff consultation on Prostaglandin Task Force, Stockholm Planning meeting: Task Force on Implantation, Stockholm Staff consultation with German Research Council, Bonn Meeting of Directors and Principal Investigators of the RTCs Staff consultation on clinical trials of Alza-T IUD, Copenhagen; and discussions with industry, Halsingborg and Stockholm Staff consultation with NICHD - exchange of information on fertility regulation research, Bethesda Steering Committee Meeting: Task Force on Male Fertility, Bethesda Staff consultation on CRC participation in clinical trials, Santiago Staff consultation on Prostaglandin Task Force, Toronto, Edmonton Training Course: Hysteroscopy, Mexico Staff consultation with the RTSs in Moscow and New Delhi and with the Bangkok team Staff consultation on medicated IUDs (Task Force on Implantation), Los Angeles Staff consultation on medicated IUDs, New Haven, Conn., United States of America Staff consultation with USAID - exchange of information on contraceptive research and development, Washington Staff consultation on medicated IUDs and collaborative clinical research with Alza-T IUDs, Palo Alto 1-2 February 3 February 3-6 February 5-7 February 5-7 February 7-9 February 10-11 February 10-12 February 11-18 February 20-22 February 26-28 February 27 February - 1 March 28 February - 1 March 5-8 March 8-9 March 12-13 March 12-16 March 13-16 March 17-22 March 20-21 March 22-23 March 25-27 March 26-28 March 28 March - 58 - Staff consultation on intra-tubal plugs, Boston Staff consultation on medicated IUDs, Worcester, Massachusetts Staff consultation on medicated IUDs, Chicago Staff consultation with industry, Berlin and Cologne Meeting of Task Force on Implantation - special consultation on immunological approaches, New York Staff consultation on establishment of a baboon screening facility, San Antonio Staff consultation on cervical contraception, Southampton, England Staff consultation with industry, Basle Visit of Prostaglandin Task Force Steering Committee to CRCs and RTC participating in Phase III clinical trials of PGF2a, Bombay, Chandigarh, New Delhi Meeting of Directors and Principal Investigators of the CRCs Steering Committee Meeting: Prostaglandin Task Force Planning Meeting: Task Force on Male Fertility Staff consultation with industry, Milan Meeting of Task Force on Ovum Transport - section on control of human oviduct function Staff consultation with industry, Amsterdam and Paris Staff consultation on medicated IUDs, Stockholm Meeting of Task Force on Acceptability Profiles Staff consultation with Prostaglandin Task Force, Stockholm Staff consultation with Male Fertility Task Force, New York Staff consultation on clinical trials in CRC network, New York Meeting of Task Force on Sperm Migration: section on vaginal rings, Los Angeles Staff consultation on medicated IUDs, Mexico Meeting of Task Force on Sperm Migration: section on cervical mucus Staff consultation on long-acting injectable contraceptives, Frankfurt 28-29 March 28-30 March 29-30 March 4-5 April 4-7 April 7-12 April 9-10 April 15-20 April 16 April 13-15 April 16-19 April 16-21 April 26-27 April 2-4 May 3-4 May 4 May 6-7 May 7-9 May 7-10 May 11 May 12 May - 20 June 14-17 May 16-18 May - 59 - Staff consultation on polymer drug delivery systems, Philadelphia, United States of America Meeting of Task Force on Abortion, Ljubljana, Yugoslavia Staff consultation on clinical trial methodology training course, Washington Meeting of Task Force on Implantation: section on immunology Staff participation in 29th Annual Meeting of the American Fertility Society, San Francisco Staff consultation with industry, Palo Alto, Columbus, Cincinatti, New York Staff participation in Biological Council Symposium on Drug Action, London; and staff consultation on ovum survival in the reproductive tract, Cambridge, United Kingdom Staff participation in 57th Annual Meeting of the Federation of American Societies for Experimental Biology, Atlantic City Staff consultation with industry, Milan Staff consultation on hysteroscopy research, Singapore Staff consultation on Prostaglandin Task Force Training Course on Clinical Trial Methodology, Bangkok Staff consultation with industry, Amsterdam Steering Committee Meeting of the Task Force on Implantation: section intrauterine medication, Stockholm Staff consultation with industry, Berlin Staff consultation with Donor Agency NORAD, Oslo Staff consultation with industry, Paris Staff consultation on Prostaglandin Task Force, Stockholm Pre-Planning meeting: Task Force on Ovulation Detection, Buenos Aires Staff participation in Bellagio Meeting Staff visits to identify social scientists for acceptability research, Egypt, Iran, India, Thailand, and Indonesia Review Group, Copenhagen Staff participation in Workshop on Population Information Consumers, Baltimore, Maryland 18 May 20-23 May 4-6 June 9-17 June 14-17 June 17-18 June 19 June 19 June 20-22 June 20-22 June 21-22 June 21-22 June 24 June 25 June 25-29 June 26-27 June 2 July 2 July 2 July 2 July 3-7 July 4 July - 60 - Staff consultation with industry, Malmo, Sweden Staff representation at Seminar on Financial Management of Research and Development, Brussels Advisory Group 4 Staff consultation at CRC Bombay, and RTC, New Delhi Staff consultation with representatives from industry and investigators carrying out collaborative clinical trials on medicated IUDs, Stockholm Staff consultation on Task Force on Methods to Regulate Ovum Transport, Charlottesville, United States of America Staff consultation with co-ordinator of Male Fertility Task Force, Oslo Staff consultation on the use of sub-human primates for testing of contraceptives, Birminghan, Alabama Staff consultation on Task Forces at the 55th Annual Meeting of Endocrine Society, Chicago Staff consultation on Task Force on Medicated IUDs, Stockholm Meeting on research of Task Force on Acceptability Profiles Meeting of Task Force on Implantation, Stockholm Steering Committee Meeting of Task Force on Male Fertility, Washington D.C. Staff consultation on Task Force on Sequelae of Induced Abortion, New Delhi Staff consultations on research on ovulation detection, Bethesda, New York, Toronto and Boston Staff consultation on long-acting injectable methods, Berlin Staff consultation on Task Force on Sequelae of Induced Abortion, Bombay CRC Staff consultation on clinical trial of tubal occlusion by hysteroscopy/ chemicals, Singapore CRC Staff visit to Department of Obstetrics and Gynaecology at the University College Hospital to assess its potential as a CRC, Kuala Lumpur Staff consultation on Task Force on Sperm Migration, Southampton Staff consultation on programme of WHO Research Team on Clinical Trial Methodology, Bangkok Staff consultation on Task Force on Injectable Contraceptives, London 6 July 8-9 July 8-13 July 9-13 July 10-13 July 15-18 July 15-20 July 16-17 July 21 July 26-27 July 30-31 July 1-3 August 6-7 August 6-8 August 20-21 August 26-28 August 27 August 3-9 September 4-5 September 6-7 September 10 September 10-12 September - 61 - Staff consultation with industry on research on new tubal occluding agents, Manchester Staff consultation at CRC, Manila Staff participation on Task Forces at the Annual Conference of the Society for the Study of Fertility, Bangor, North Wales Meeting of Task Force on Immunology: sperm and trophoblastic antigens Staff consultation at CRC, Seoul Staff consul tat ion with co-ordinator of Male. Fertility Task Force, Seattle, United States of America Staff participation in Gordon Research Conference, Meriden, New Hampshire, United States of America Staff participation at Directors' Meeting of NIH Centres and Conference on Reproductive Behaviour, Beaverton, United States of America Staff consultation with scientists at the University of Washington, St Louis and at Beaverton Primate Centre Meeting of Task Force on Ovum Transport: tubal occlusion, Seattle, United States of America Sfaff consultation with industry, Amsterdam Steering Committee Meeting of Task Force on Implantation: IUD Section, Stockholm Staff consultation on multi-centre collaborative clinical trial of low dose progestagens, High Wycombe and Taplow, United Kingdom Meeting of Task Force on Ovulation Detection Steering Committee Meeting of Task Force on Prostaglandins, Stockholm Meeting of Task Force on Male Fertility Meeting of Task Force on Sequelae of Induced Abortion Staff site visits to potential CRCs, Aberdeen, Edinburgh, Manchester, Sheffield and London, United Kingdom Meeting of Task Force on Medicated IUDs, Los Angeles Meeting on Medicated Vaginal Rings, Los Angeles Steering Committee Meeting of Task Force on Immunology, Strasbourg, France Meeting of Task Force on Sperm Migration: cervical/uterine contraception, Chicago 10-14 September 17-18 September 17-20 September 20 September 21 September 23 September 24-28 September 30 September 13 October 8-10 October 15-17 October - 62 - Meeting of Task Force on Sequelae of Induced Abortion, Newcastle-upon-Tyne, United Kingdom Steering Committee Meeting of Task Force on Ovum Transport: human oviduct function, San Antonio, United States of America Meeting on Pharmacological Models Steering Committee Meeting of Task Force on Ovum Transport: tubal occlusion, Columbus, Ohio Steering Committee Meeting of Task Force on Immunological Methods, Columbus, Ohio Staff consultation on Task Force on Immunology, Shrewsbury, Massachusetts Staff site visit to potential CRCs, Montreal; London, Ontario; Toronto Staff participation in WPRO Seminar on Medical and Surgical Aspects of Family Planning, Tokyo Staff consultation with RTC Three Nations Programme, Buenos Aires Advisory Group 5