Pandemic influenza preparedness (PIP) framework: partnership contribution (PC) preparedness high-level implementation plan II 2018-2023: a summary

Pandemic Influenza Preparedness Framework Partnership Contribution (PC) Preparedness High-Level Implementation Plan 2018-2023 A SUMMARY Pandemic influenza preparedness aims to strengthen country, regional and global capacities to respond to an event that will affect all continents, peoples and sectors. Preparing for the next influenza pandemic requires a collaborative, whole-of-government and whole-of-society approach. About this plan This High-Level Implementation Plan (HLIP II) will guide the use of WHO’s Pandemic Influenza Preparedness (PIP) Framework Partnership Contribution (PC) Preparedness Funds from 2018 to 2023. The plan was developed with input from the PIP Advisory Group, Global Influenza Surveillance and Response System (GISRS), industry, and civil society organizations. Pandemic flu facts Pandemic influenza deaths estimates PC Outcome and its indicators In flu en za s ur ve ill an ce s ys te m s, k no w le dg e an d ca pa ci ti es fo r a ti m el y an d ap pr op ri at e re sp on se to p an de m ic in flu en za a re e st ab lis he d an d st re ng th en ed O ut co m e In di ca to r 1 : % o f M em be r S ta te s sh ar in g IV PP s w ith G IS RS a cc or di ng to W H O IV PP s ha rin g gu id an ce O ut co m e In di ca to r 2 : % o f M em be r S ta te s re po rt in g to F lu N et O ut co m e In di ca to r 3 : % o f M em be r S ta te s re po rt in g to F lu ID O ut co m e In di ca to r 4 : % o f M em be r S ta te s w ith b ur de n of d is ea se e st im at es th at h av e be en c on si de re d by N IT A G o r o th er d ec is io n- m ak in g bo di es O ut co m e In di ca to r 5 : # o f M em be r S ta te s th at h av e im pl em en te d a de fin ed re gu la to ry a pp ro ac h th at e na bl es ti m el y ap pr ov al fo r u se o f p an de m ic in flu en za p ro du ct s O ut co m e In di ca to r 6 : % o f M em be r S ta te s th at d ev el op ed o r u pd at ed a p an de m ic in flu en za p re pa re dn es s pl an Outputs and their indicators L& S (O ut pu t 1 ) N at io na l i nf lu en za la bo ra to ry a nd s ur ve ill an ce sy st em s co nt ri bu te to G IS R S fo r t im el y ri sk as se ss m en t & re sp on se m ea su re B O D (O ut pu t 2 ) In flu en za d is ea se bu rd en e st im at es a re us ed fo r p ub lic h ea lt h de ci si on s R EG (O ut pu t 3 ) Ti m el y ac ce ss to qu al it y- as su re d pa nd em ic in flu en za pr od uc ts is s up po rt ed R CC E (O ut pu t 4 ) To ol s an d gu id an ce a re av ai la bl e fo r c ou nt ri es to en ha nc e in flu en za ri sk co m m un ic at io n an d co m m un it y en ga ge m en t D EP (O ut pu t 5 ) P la ns fo r e ff ec ti ve & e ff ic ie nt de pl oy m en t o f p an de m ic su pp lie s ar e op ti m iz ed IP P P (O ut pu t 6 ) N at io na l p an de m ic in flu en za p re pa re dn es s & re sp on se p la ns a re u pd at ed in th e co nt ex t o f a ll- ha za rd s pr ep ar ed ne ss a nd g lo ba l he al th s ec ur it y 1. 1 # o f r is k as se ss m en ts p ub lis he d fo r i nf lu en za vi ru se s at th e hu m an -a ni m al in te rf ac e fo llo w in g W H O g ui da nc e 1. 2 # o f M em be r S ta te s re po rt in g in flu en za s ev er ity in di ca to rs to W H O 1. 3 % o f M em be r S ta te s th at p ar tic ip at ed a nd w er e 10 0% c or re ct fo r n on -s ea so na l i nf lu en za v iru s id en tif ic at io n in th e W H O P CR E xt er na l Q ua lit y A ss es sm en t P ro gr am m e (E Q A P) 1. 4 % o f M em be r S ta te s th at p ar tic ip at ed a nd w er e 10 0% c or re ct fo r s ea so na l i nf lu en za v iru s id en tif ic at io n in th e W H O P CR E xt er na l Q ua lit y A ss es sm en t P ro gr am m e (E Q A P) 1. 5 % o f M em be r S ta te s th at h ad ti m el y sh ar in g of in flu en za v iru s is ol at es o r c lin ic al s pe ci m en s w ith W H O C Cs a cc or di ng to W H O g ui da nc e 1. 6 # o f z oo no tic in flu en za v iru se s an d ot he r i nf lu en za vi ru se s w ith p an de m ic p ot en tia l c ha ra ct er iz ed b y G IS RS 2. 1 # o f M em be r S ta te s w ith p ub lis he d di se as e bu rd en e st im at es b as ed on d at a co lle ct ed s in ce 20 11 3. 1 # o f M em be r S ta te s w hi ch s tr en gt he ne d na tio na l r eg ul at or y ca pa ci ty to o ve rs ee pa nd em ic in flu en za pr od uc ts a s p er W H O be nc hm ar ki ng a nd ID P im pl em en ta tio n 4. 1 # o f u se rs fr om ta rg et au di en ce s w ho c om pl et ed le ar ni ng m od ul es o n in flu en za a nd re la te d RC CE co nt en t o n th e O pe nW H O pl at fo rm 4. 2 # o f M em be r S ta te s th at ut ili ze d RC CE s up po rt fo r in flu en za p re pa re dn es s or re sp on se 5. 1 A nn ua l s im ul at io n ex er ci se co nd uc te d to te st g lo ba l de pl oy m en t o f p an de m ic in flu en za v ac ci ne s an d ot he r pr od uc ts 5. 2 # o f M em be r S ta te s th at h av e un de rg on e a na tio na l a na ly si s of in flu en za v ac ci ne pr oc ur em en t o r p ro du ct io n su st ai na bi lit y 6. 1 % o f M em be r S ta te s th at ex er ci se d th ei r p an de m ic in flu en za p re pa re dn es s pl an in cl ud in g ac ro ss s ec to rs Deliverables a. R is k an d se ve rit y of in flu en za , i nc lu di ng a t t he hu m an -a ni m al in te rf ac e, a re ro ut in el y as se ss ed b. Q ua lit y in flu en za v iru s de te ct io n ca pa ci ty is s us ta in ed c. Co un tr ie s ar e su pp or te d to c on si st en tly re po rt in flu en za d at a to g lo ba l p la tf or m s d. Co un tr ie s ar e su pp or te d to s ha re ti m el y re pr es en ta tiv e in flu en za s am pl es w ith W H O C Cs e. In flu en za C V V s, v iru s de te ct io n pr ot oc ol s an d re ag en ts , a nd re fe re nc e m at er ia ls a re ro ut in el y up da te d a. R ep re se nt at iv e na tio na l, re gi on al a nd g lo ba l di se as e bu rd en e st im at es ar e av ai la bl e b. D is ea se b ur de n fin di ng s ar e co m m un ic at ed to na tio na l a nd in te rn at io na l e xp er t bo di es in a fo rm at th at pr om ot es e vi de nc e- ba se d de ci si on m ak in g a. N at io na l r eg ul at or y ca pa ci ty fo r p an de m ic in flu en za p ro du ct s is st re ng th en ed b. A do pt io n of re gu la to ry pa th w ay s th at a cc el er at e ap pr ov al fo r u se o f pa nd em ic in flu en za pr od uc ts is p ro m ot ed a. Co un tr ie s an d fr on t- lin e re sp on de rs h av e ac ce ss to re so ur ce s fo r i nf lu en za ri sk co m m un ic at io n, c om m un ity en ga ge m en t a nd s oc ia l sc ie nc e- ba se d in te rv en tio ns b. Te ch ni ca l a ss is ta nc e is pr ov id ed to c ou nt rie s to p la n an d ex er ci se in flu en za ri sk co m m un ic at io n an d co m m un ity e ng ag em en t a. A c om m on a pp ro ac h to m an ag e gl ob al d ep lo ym en t op er at io ns is d ev el op ed a nd re gu la rly te st ed w ith st ak eh ol de rs a nd d ep lo ym en t pa rt ne rs b. N at io na l d ep lo ym en t p la nn in g pr oc es s is re vi se d an d up da te d c. Te ch ni ca l a ss is ta nc e to d ev el op po lic ie s fo r s us ta in ab le in flu en za v ac ci ne p ro cu re m en t an d pr od uc tio n is p ro vi de d to co un tr ie s a. Co un tr ie s ar e su pp or te d to de ve lo p, te st a nd u pd at e th ei r i nf lu en za p an de m ic pr ep ar ed ne ss p la n Historically, pandemics occur 3-4 times each century. It is impossible to predict when the next one will happen. The virus spreads quickly. Air travel has greatly increased the speed with which the virus can spread. All people, including pregnant women, children, elderly, chronically ill, and healthy young adults, are at risk. During each of the four most recent pandemics, between 0.5 and 4.8 percent of global GDP was lost. 40 million 1.1 million 1 million 150-575 thousand 1918 1957 1968 2009 H1N1 virus H2N2 virus H3N2 virus H1N1 pdm09 virus © W H O 2 01 8. S om e rig ht s re se rv ed . T hi s w or k is a va ila bl e un de r t he C C BY -N C- SA 3 .0 IG O li ce nc e. W H O / W H E / I H M / PI P / 2 01 8. 02 The WHO PIP Framework is a landmark international arrangement that aims to improve global pandemic influenza preparedness and response. The PIP Framework is an innovative partnership among Member States, industry, civil society and other stakeholders. The PIP Framework has many components, notably a PIP Benefit Sharing System that includes sustainable financing through PC. Influenza vaccine, pharmaceutical and diagnostic manufacturers that use GISRS, which is the backbone of the PIP Framework, are expected to make an annual financial contribution. These funds amount to US $28 million each year. Most PC Funds are used to strengthen GISRS by building country, regional and global capacities that are needed to respond to an influenza pandemic. HLIP II outlines how these PC Preparedness Funds will be used to improve global pandemic influenza preparedness and response capacities in 2018-2023. Progress: A world better prepared During the first HLIP (2013-2017), PC Preparedness Funds ($64 million) contributed to improving many different capacities both globally and in 72 countries spread among WHO’s six regions. The positive impact of PC investments include strengthened capacities to: • Detect, monitor and share influenza viruses with pandemic potential; • Provide timely influenza situation analyses and risk assessments; • Estimate influenza disease burden for evidence-based policy development; • Facilitate rapid approval and deployment of pandemic influenza products; • Communicate risk during an influenza pandemic. High-level results Challenges and way forward Nonetheless, the world remains vulnerable and must sustain these efforts to strengthen preparedness. Based on an assessment of gaps and needs, key areas that require continued support include: laboratory and surveillance systems, national policies for influenza control based on burden of disease, capacities for risk communications, ensuring that safe and effective pandemic products are available to countries in a timely manner and are able to be rolled-out quickly, and that countries have updated pandemic plans that support an appropriate response. HLIP II has been targeted to meet these needs, as outlined in the results hierarchy on the following page. HLIP II indicators are intentionally aligned with those used by other initiatives to improve global pandemic influenza preparedness. This will enable all partners and institutions to show and share in the progress and impact achieved. Fund allocation PC Preparedness and Response funds are divided into two parts as required under the Framework. Response funds are set aside to be used in the time of a pandemic. Preparedness funds are used to improve pandemic preparedness, primarily at regional and country levels. The allocation of funds among Outputs and to countries and regions is based on principles of need and equity, and may be adjusted over time. The majority of funds are administered by WHO Regional and Country Offices. Preparedness context Preparedness consists of the knowledge, capacities and systems needed to reduce vulnerability and enhance resilience. PC Preparedness Funds are implemented in synergy with other WHO programmes and initiatives aimed at strengthening preparedness and response capacities. HLIP II will support implementation of the Pandemic Influenza Risk Management (PIRM) guidance (2017). The Plan will also collaterally benefit the core capacities that countries are required to achieve under the International Health Regulations (IHR, 2005), and build on the momentum countries established for vaccine policy development during the Global Action Plan for Influenza Vaccines (GAP). Planning principles Allocation of PC Preparedness Funds is guided by planning principles that ensure the limited resources are used efficiently and effectively to improve influenza preparedness and response capacities, and that equity remains at the heart of implementation. What is the PIP Framework? Accountability WHO will be fully accountable for the use of all PC funds Eectiveness Doing the right things, in the right way, and in the right place to create the maximum impact Transparency Allocation and use of PC funds will be done transparently‘SMART’ outputs Outputs will be Specic, Measurable, Attainable, Relevant and Time-bound Sustainability Implementation will be planned such that Member States can sustain activities Flexibility Within planning parameters, funds may be reprogrammed among outputs to maximize achievements * WHO’s Programme Support Costs (PSC) are applied as funds are expended Annual PC funds US$28 million PC Preparedness and Response funds 90% PC Preparedness funds * 90% PC Response funds * (set aside for pandemic) 30% Regional & country oces technical units HQ technical units Outputs 1 and 6 70% Outputs 2-5 30% PIP Secretariat * 10% See the full High-Level Implementation Plan II: http://www.who.int/influenza/pip/en/ Starting in mid-2018, track implementation progress: http://open.who.int/ 42 36 22 10 48 8 1st routinely share influenza viruses with GISRS additional countries additional countries additional countries additional countries targeted countries global simulation portal influenza courses share influenza epidemiological data with WHO through ‘FluID’ share influenza virological data with WHO through ‘FluNET’ with influenza burden estimates and a new global influenza mortality estimate now have an approach to facilitate the timely approval of pandemic influenza products during an emergency ‘PIP Deploy’, launched for pandemic influenza vaccine deployment on ‘OpenWHO’, the new online knowledge-transfer platform