Judgment of the Court (Fourth Chamber) of 18 December 2025.#Pesticide Action Network Europe (PAN Europe) v European Commission.#Appeal – Agriculture – Plant protection products – Article 4 – Regulation (EC) No 1107/2009 – Implementing Regulation (EU) 2021/2049 – Renewal of the approval of the active substance ‘cypermethrin’ – Request for internal review – Regulation (EC) No 1367/2006 – Article 10(1) – Decision refusing the request – Risk assessment and risk management – Identification of critical areas of concern – Realistic conditions of use – Precautionary principle.#Case C-316/24 P.