Opinion of Advocate General Kokott delivered on 20 April 2023.#Global Silicones Council and Others v European Chemicals Agency.#Appeal – Establishment of a list of substances identified for eventual inclusion in Annex XIV to Regulation (EC) No 1907/2006 (REACH Regulation) – Entry of octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5) and dodecamethylcyclohexasiloxane (D6) in that list – Persistent, bioaccumulative and toxic substances – Very persistent and very bioaccumulative substances – Bioaccumulation – Bioconcentration factor