Syphilis test availability and uptake at medical facilities in southern China

Bull World Health Organ 2011;89:798–805 | doi:10.2471/BLT.11.089813 Research 798 Syphilis test availability and uptake at medical facilities in southern China Li-Gang Yang,a Joseph D Tucker,a Cheng Wang,a Song-Ying Shen,a Xiang-Sheng Chen,b Bin Yanga & Rosanna Peelingc Introduction The last decade has seen a pronounced resurgence of syphilis in China,1–3 especially in south-eastern coastal provinces, which carry the greatest disease burden.4,5 One such province is Guangdong. In 2009 it reported 39 112 syphilis cases and prevalence reached 41 cases per 100 000 total population, or nearly twice the rate in all of China (25 per 100 000).6 Syphilis is now the second most commonly reported communicable disease in Guangdong province,6 where a high prevalence has been observed among female sex workers7 and men who have sex with men.8,9 Mother-to-child syphilis transmission is an important public concern in epidemic areas because syphilis can cause spontaneous abortion, stillbirth and irreversible congenital defects.10 These adverse outcomes are fortunately preventable through effective prenatal screening programmes. However, organizing such programmes is challenging, especially in places where the health system faces problems. For example, in 2001 the state of Florida in the United States of America (USA) passed a law requiring that at least two syphilis tests be administered during pregnancy, but operational research from Miami showed that only 83% of pregnant women were screened at least once.11 In a study from Mongolia, only 77% of 3519 pregnant women were screened and the presence of congenital syphilis showed an association with late-term an- tenatal care and with living farther from care services.12 The influence of health systems issues on timely prenatal syphilis screening has been observed in several other countries, includ- ing Bolivia, Kenya and South Africa.13 In a project in Shenzhen (Guangdong province) in which 477 656 pregnant women were screened for syphilis, 0.5% had a positive treponemal test and mother-to-child transmission was prevented in 99.1% of these cases as a result of screening.14 Although Shenzhen is the most developed city in Guangdong province and the one with the best medical infrastructure, most municipalities have far fewer resources, less equipped laboratories and limited syphilis testing capacity. The non- treponemal test, which is the one most commonly used to screen for syphilis, requires trained laboratory personnel, a refrigerator, a centrifuge and a rotator.15 Although China’s new 10-year National Syphilis Control Plan explicitly mandates widespread prenatal screening for syphilis, the existence of lo- cal capacity to undertake such screening, especially in resource constrained regions, is unclear. This study examined the status of syphilis testing capacity, prenatal syphilis screening coverage and types of syphilis tests in different types of medical facilities offering prenatal care in Guangdong province. Methods Study sites Guangdong province is in south-eastern China and borders the South China Sea. Several administrative levels exist in the province, from municipality down to county/district, to township and to village. In 2010 there were 21 municipalities divided into 121 counties/districts. Of these 21 municipalities, seven (Guangzhou, Zhongshan, Zhuhai, Dongguan, Shenzhen, Jiangmen and Fushan) are in the central, more developed re- gion known as the Pearl River Delta. Of the 14 less developed, more resource-constrained municipalities, seven (Chaozhou, Objective To examine syphilis testing capacity, screening coverage rates and types of syphilis tests used in medical facilities in southern China. Methods Eleven of the 14 municipalities in Guangdong province participated. Data on syphilis testing capacity, screening coverage and types of syphilis tests used were collected from all types of public medical facilities offering prenatal care (n = 109). A total of 494 680 women who delivered during 2004–2008 were studied. Findings In 2008, 54 196 pregnant women (43.1%) were not screened for syphilis. Among such women, 32 863 (60.6%) attended clinics without any syphilis testing capacity and 21 333 (39.4%) attended clinics that performed testing but were not screened. The likelihood of not having syphilis test capacity was much higher for hygiene stations (odds ratio, OR: 10; 95% confidence interval, CI: 4–25), services at the township level (OR: 33; 95% CI: 10–100) and services with ≤ 1000 deliveries per year (OR: 1.002; 95% CI: 1.001–1.003). These same service characteristics correlated with lower screening coverage rates (P < 0.01). Only one antenatal clinic had the capacity to conduct both treponemal and non-treponemal tests for diagnosing syphilis. Conclusion Syphilis screening is available in very few of the basic medical facilities offering prenatal care where most neonates in southern China are delivered. In light of this and of the increasing incidence of syphilis in the area, expanding point-of-care rapid syphilis testing is a priority. a Guangdong Provincial Center for STI Control & Prevention, Division of STD Control, No.10 Xian Lie Dong Heng Rd, Guangzhou 510500, China. b National Center for STD Control, Nanjing, China. c Diagnostics Department, London School of Hygiene & Tropical Medicine, London, England. Correspondence to Li-Gang Yang (e-mail: yanglg3@yahoo.com). (Submitted: 30 April 2011 – Revised version received: 16 July 2011 – Accepted: 19 July 2011 – Published online: 27 September 2011 ) Bull World Health Organ 2011;89:798–805 | doi:10.2471/BLT.11.089813 799 Research Syphilis testing at prenatal clinics in southern ChinaLi-Gang Yang et al. Shantou, Jieyang, Shanwei, Huizhou, Heyuan and Meizhou) are in the east of the province, five (Zhaoqing, Yunfu, Yangjiang, Maoming and Zhanjing) are in the west and two (Qingyuan and Sha- oguan) are in the north.16 The Pearl River Delta had 11.4 primary syphilis cases per 100 000 population in 2008, a rate much higher than the province’s overall rate of 7.6 primary syphilis cases per 100 000.4 The case definition of syphilis in China includes both clinical criteria as well as laboratory confirmation with treponemal and non-treponemal tests. Like other parts of China, Guang- dong has a vertically organized public hospital system that goes from the municipal level down to the township level. A municipality generally has one municipal general hospital (known as a people’s hospital or central hospital), one municipal hospital for women and children and one municipal hospital of traditional Chinese medicine. Admin- istratively nested within municipalities, counties and districts have corollary general hospitals, women’s and chil- dren’s hospitals and traditional Chinese medicine hospitals. Each township has one hygiene station, which is a public health-care post offering basic services. General hospitals and women’s and chil- dren’s hospitals are where most pregnant women in urban areas seek prenatal care and deliver their babies. In contrast, most women in rural China deliver their babies either at home or at a township- level hygiene station. High-risk or complicated pregnancies are referred to county- or municipal-level facilities that provide a higher level of care. This study was conducted in the 14 less developed municipalities selected for inclusion in the health services re- search project. All departments for the control of sexually transmitted infections (STIs) at the municipality level were contacted by phone to invite them to participate in a research project jointly organized by the Guangdong Provincial STI Control Department and the Guangdong Provincial Health Bureau. Eleven municipalities repre- senting all the major regions outside the Pearl River Delta agreed to participate. The local STI control centre in each of these municipalities filled out a written survey developed by the Guangdong Provincial STI Control Department in collaboration with the Guangdong Provincial Health Bureau. Since the Provincial Health Bureau has jurisdic- tion over all hospitals in the province, it has the authority to conduct projects that cut across different health systems. The main goal of the survey was to record data about syphilis testing in all clinical facilities where women in the administrative region give birth. Data regarding whether or not a woman was tested for syphilis were obtained from internal administrative clinic records. Women whose syphilis test results were positive were treated with antibiotics in accordance with standard Chinese guidelines. The survey was conducted in all hospitals that delivered babies within the municipality and included the following items: name of hospital; type of hospital (general, women’s and children’s, tradi- tional Chinese medicine, hygiene sta- tion); administrative level (municipal, county/district, township); total num- ber of women who delivered babies in 2006–2008; number of pregnant women screened for syphilis at least once before delivery in 2006–2008; treponemal and non-treponemal syphilis screening tests available as of 2008. Local STI control centres, with tech- nical assistance from the Guangdong Provincial Centre for STI Control and the Provincial Health Bureau, collected all the surveys from local hospitals and reported back to the Guangdong Provin- cial Centre for STI Control. One hospital that had inconsistent data was contacted and asked to clarify the requested infor- mation. In line with previous research, a health systems variable analysing the number of annual pregnancies was di- chotomized into > 1000 pregnancies and ≤ 1000 pregnancies.17 Data were entered into Excel 2010 (Microsoft, Redmond, USA) and analysed using SPSS 11.5 (SPSS Inc., Chicago, USA). χ2 tests and Wilcoxon ranks sum tests were used to analyse the data, with statistical signifi- cance set at P < 0.05. This research study was exempted from ethical review by the Guangdong Provincial STD Control Centre Insti- tutional Review Board in Guangzhou, China. Results Summary statistics Of the 109 medical facilities studied, most (76/109) were hygiene stations and belonged to the township ad- ministrative level. Of the 109 medical facilities, 51 were in the western part of the province. The 109 medical set- tings recorded a total of 494 680 births from 2004–2008; 125 645 of these births occurred in 2008, and that year 57% (71 449/125 645) of the pregnant women who attended the 109 medical facili- ties received at least one syphilis test. Of the pregnant women in the sample who were not screened for syphilis, 61% (32 863/54 196) had attended pre- natal clinics without syphilis screening capacity and 39% (21 333/54 196) had attended a clinic with screening capacity but had not been screened. Syphilis testing capacity Local syphilis testing capacity at medical facilities following pregnant women was limited in this sample. Of the 109 medi- cal facilities studied, only 40 (36.7%) provided some form of syphilis testing (Table 1). The most limited syphilis testing capacity was observed at hygiene stations; of the 76 facilities of this type, only 9 (11%) performed syphilis tests. Four of the 76 hygiene stations were near municipal or county capitals; of these four hygiene stations, three offered syphilis testing. Women’s and children’s hospitals, traditional Chinese medicine hospitals and general hospitals all had significantly higher syphilis testing ca- pacity than hygiene stations. The most limited syphilis testing capacity was seen at the township administrative level, with only 9 of the 75 (12%) medical care facilities having such capacity. Medical settings with fewer deliveries per year had more limited syphilis testing capac- ity. There was no difference in syphilis test capacity between different regions in Guangdong province. Prenatal syphilis testing coverage In 2008, the 40 medical facilities with syphilis testing capacity recorded a total of 92 782 births. Only 77% (71 449/92 782) of the mothers who delivered received some form of syphilis testing. Syphilis screening coverage rates were higher at women’s and children’s hospitals, general hospitals, higher administrative levels and medical facilities with a larger num- ber of deliveries (Table 2). Very few medical facilities in this study were able to meet the national benchmark of ≥ 80% for syphilis screen- ing coverage. Of the 40 medical facilities that had syphilis testing capacity, only 26 (65%) reached the coverage benchmark, and 11 of them were children’s and women’s hospitals (Table 3). Bull World Health Organ 2011;89:798–805 | doi:10.2471/BLT.11.089813800 Research Syphilis testing at prenatal clinics in southern China Li-Gang Yang et al. Types of syphilis tests Of the hospitals that offered syphilis test- ing, very few had the capacity to perform both treponemal tests (e.g. the Trepone- ma pallidum particle agglutination assay, or TPPA) and non-treponemal tests (e.g. the toluidine red unheated serum test, or TRUST) that are necessary to diagnose syphilis according to the Chinese case definition. The majority (85%) of medical facilities only performed non-treponemal tests. Only one women’s and children’s hospital performed both non-treponemal and treponemal tests. One tenth of all the hospitals had enzyme immunoassays for syphilis diagnosis (Table 4). Discussion To our knowledge, this is the first descrip- tion of the uptake and availability of syphi- lis testing in medical facilities in China. Our data show that syphilis tests are not universally available in these settings, es- pecially in hygiene stations, where many pregnant women receive prenatal care.18 Table 1. Associations between syphilis testing capacity and health system variables in Chinese medical facilities where deliveries were attended in 2008, Guangdong province, China Variable No. of facilities Testing capacity OR 95% CI Any syphilis testing No syphilis testing No. % No. % Type of facility General hospital 14 13 92.9 1 7.1 96.8 11.3–830.6 WCH 14 14 100.0 0 0 – – TCMH 5 4 80.0 1 20.0 29.8 3.0–296.8 Hygiene station 76 9 11.8 67 88.2 R – Administrative level Municipal 10 9 90.0 1 10.0 66.0 7.5–584.0 County 24 22 91.7 2 8.3 80.7 16.2–402.1 Township 75 9 12.0 66 88.0 R – Region North 15 7 46.7 8 53.3 1.8 0.5–2. 9 West 51 19 37.3 32 62.7 1.2 0.5–2. 9 East 43 14 32.6 29 67.4 R – Annual pregnancies > 1 000 34 28 82.4 6 17.6 1.002 1.00–1.00 ≤ 1 000 75 12 16.0 63 84.0 R – Total 109 40 36.7 69 63.3 – – CI, confidence interval; OR, odds ratio; R, reference; TCMH, traditional Chinese medicine hospital; WCH, women’s and children’s hospital. Table 2. Pregnant women screened for syphilis in different types of medical facilities, Guangdong province, China, 2008 Variable No. of pregnancies Women screened Za P No. % Type of facility General hospital 26 128 18 988 72.7 −7.01 < 0.01 WCH 58 040 47 104 81.2 −7.64 < 0.01 TCMH 3 431 1 771 51.6 −3.92 < 0.01 Hygiene station 38 046 3 906 10.3 R – Administrative level Municipal 26 144 20 423 78.1 −6.28 < 0.01 County 61 949 47 400 76.6 −7.74 < 0.01 Township 37 552 3 906 10.4 R – Region West 39 479 23 585 59.7 −0.77 0.44 East 66 514 38 335 57.6 −0.57 0.57 North 19 652 9 849 50.1 R – Annual pregnancies > 1 000 94 474 67 117 93.5 −7.82 < 0.01 ≤ 1 000 31 171 4 652 6.5 R – R, reference; TCMH, traditional Chinese medicine hospital; WCH, women’s and children’s hospital. a Z, standard score. Bull World Health Organ 2011;89:798–805 | doi:10.2471/BLT.11.089813 801 Research Syphilis testing at prenatal clinics in southern ChinaLi-Gang Yang et al. Studies in other contexts have also found low syphilis screening coverage among pregnant women. Only 57% of the pregnant women who attended the 109 hospitals included in this study received syphilis testing. This rate is higher than the average of 38% and 43% observed in sub-Saharan Africa19 and the United Republic of Tanzania,20 respectively, but lower than the 77% syphilis screening coverage rate reported in Mongolia.12 The National Syphilis Control Plan in China established a 2015 benchmark to routinely screen 80% of pregnant women in cities and 60% of pregnant women in rural areas for syphilis. Reaching the benchmark in urban areas may be easier because wom- en’s and children’s hospitals and general hospitals, which showed high screening coverage rates in our study, are where most urban women seek prenatal care. Conversely, achieving the benchmark in rural areas may be more challenging for several reasons. First, hygiene stations are the main and sometimes only facili- ties that provide prenatal care in those catchment areas, and in our sample such facilities had a screening coverage of only 10.3%. Second, in less developed regions some women still give birth at home and have fewer opportunities to be tested for syphilis. The rate of delivery in Table 3. Predictors of > 80% pregnant women screened for syphilis at medical facilities where deliveries were attended in 2008 in Guangdong province, China Variable Total ≤ 80% screened > 80% screened OR 95% CI No. % No. % Type of facility 0.784 0.44–1.39 General hospital 13 5 38.5 8 61.5 – – WCH 14 3 21.4 11 78.6 – – TCMH 4 1 25.0 3 75.0 – – Hygiene station 9 5 55.6 4 44.4 – – Administrative 0.724 0.29–1.83 Municipal 9 3 33.3 6 66.7 – – County 22 6 27.3 16 72.7 – – Township 9 5 55.6 4 44.4 – – Region 0.905 0.36–2.28 North 7 3 42.9 4 57.1 – – East 14 5 35.7 9 64.3 – – West 19 6 31.6 13 68.4 – – Annual pregnancies 1.51 0.37–4.09 > 1 000 26 9 32.1 19 67.9 – – ≤ 1 000 14 5 41.7 7 58.3 – – Total 40 14 – 26 – – – CI, confidence interval; OR, odds ratio; TCMH, traditional Chinese medicine hospital; WCH, women’s and children’s hospital. Table 4. Syphilis testing methods available at various medical facilities where deliveries were attended in 2008, Guangdong province, China Variable EIA only TRUST/RPR and TPPA TPPA only TRUST/RPR only No. % No. % No. % No. % Type of facility General hospital 2 15.4 0 – 1 7.7 10 76.9 WCH 1 7.1 1 7.1 0 – 12 85.7 TCMH 0 – 0 – 0 – 4 100 Hygiene station 1 11.1 0 – 0 – 8 88.9 Administrative Municipal 0 – 1 11.1 0 – 8 88.9 County 3 13.6 0 – 1 4.6 17 81.8 Township 1 11.1 0 – 0 – 4 88.9 Region West 2 10.5 0 – 0 – 17 89.5 East 2 14.3 0 – 1 7.1 11 78.6 North 0 – 1 14.3 0 – 6 85.7 Total 4 10 1 2.5 1 2.5 29 85 EIA, enzyme immunoassay; RPR, rapid plasma reagin; TCMH, traditional Chinese medicine hospital; TPPA, Treponema pallidum particle agglutination; TRUST, toluidine red unheated serum test; WCH, women’s and children’s hospital. Bull World Health Organ 2011;89:798–805 | doi:10.2471/BLT.11.089813802 Research Syphilis testing at prenatal clinics in southern China Li-Gang Yang et al. health facilities has increased in recent years21 but has not reached 100% yet. Our finding that testing capacity at hygiene stations is limited is consistent with the findings of other studies in China.22 The geographic barriers and lack of financial support described in studies outside China may be limiting syphilis testing capacity at hygiene sta- tions in China as well.12,23 China’s new health-care reform plan emphasizes infrastructural and human resource development within the three-tier facil- ity network (county, town and village level),24 with hygiene stations playing a key role at the township level. Health care reform may help to increase syphi- lis testing capacity at the local, hygiene station level, but it remains to be de- termined whether reform will directly affect the availability of syphilis testing and key infrastructure. Our findings suggest that large gaps exist between routine syphilis testing capacity in resource-constrained regions of China and screening coverage targets under the National Syphilis Control Plan. However, this study was con- ducted in 2008 and several provincial and national programmes to improve syphilis testing capacity have been im- plemented since. Our findings triggered the launching of a Guangdong pilot programme for rapid syphilis testing at prenatal care facilities in the 14 study municipalities.25 The rapid treponemal test provides an inexpensive, simple and quick diagnostic method with good test characteristics.26 Our health service study describes a major opportunity to substantially expand the scope of routine syphilis testing through the use of the rapid syphilis test. Effectively providing syphilis testing and ensuring 100% prenatal screening coverage are important preconditions for success- fully achieving the goals established by China’s National Syphilis Control Plan. Rapid point-of-care syphilis testing27–30 is an excellent option, especially in rural areas with limited laboratory facilities. However, laboratory quality control must be considered when implement- ing syphilis screening in prenatal care facilities since inaccurate syphilis testing has been described in other areas31 and in Guangdong province.32 This study has several limitations. First, the exact barriers to syphilis screening, such as lack of electricity and trained personnel, were not recorded. The National Syphilis Control Plan explicitly calls for expanding the train- ing of medical personnel in syphilis programme management.33 Second, this study only sampled public medi- cal facilities providing prenatal care in southern China and the findings may not be applicable to other regions and types of facilities. We believe, however, that the hygiene stations in this study are probably very similar to facilities in other middle- and low-income settings where prenatal clinics have limited infrastructure and medical personnel.34 Third, deliveries at home or in private prenatal care facilities were not sampled, and both settings are characterized by lower syphilis testing capacity.35 Finally, the timing of prenatal care, a crucial aspect of congenital syphilis prevention, was not determined.36 Timely prenatal care, preferably in the first trimester, is essential for effective syphilis prevention programmes.37 The elimination of congenital syphilis is a global health priority, but organizing effective prenatal screening, especially in the resource-constrained settings most heavily affected by con- genital syphilis, remains a substantial challenge. Our research has identified the type of prenatal care facilities in these settings that would benefit the most from rapid syphilis testing. Further research is necessary to guide comprehensive implementation of the National Syphilis Control Plan in China and to meet established tar- gets for the elimination of congenital syphilis. ■ Competing interests: None declared. Funding: This study was funded by the Guangdong Provincial Medical Science and Technology Research Funding Award(C2009020), the WHO Rap- id Syphilis Test Project (UNICEF/ UNDP/World Bank/WHO A70577), the National STD Control Centre and an NIH Fogarty K01 Award (US NIH 1K01TW008200-01A1). صخللما ينصلا بونج في ةيحصلا قفارلما في يرهزلا رابتخا ءارجإو رفوت تلادعمو ،يرهزلا رابتخا ءارجإ لىع ةردقلا صحف ضرغلا قفارلما في ةمدختسلما يرهزلا رابتخا عاونأو ،هنع يرحتلاب ةيطغتلا .ينصلا بونج في ةيحصلا في ةيدلب 14 نم ةيدلب ةشرع ىدحإ ثحبلا في تكراش ةقيرطلا ءارجإ لىع ةردقلا لوح تايطعلما تعجمو .غنودغناوغ ةعطاقم رابتخا عاونأو ،هنع يرحتلاب ةيطغتلا تلادعمو ،يرهزلا رابتخا يتلا ةيمومعلا ةيبطلا قفارلما عاونأ عيجم نم ةمدختسلما يرهزلا ةسارد ترج دقو .)109 = اهددع( ةدلاولل ةقباسلا ةياعرلا مدقت .2008-2004 تاونسلا للاخ ندلو ةأرما 494680 ةأرما 54196 ـل يرهزلا نع يرحتلا متي لم ،2008 ماع في جئاتنلا نعجار )60.6( ةأرما 32683 نهنيب نمو .)43.1%( ًلاماح تعجارو ،يرهزلا رابتخا ءارجإ لىع ةردقلا ايهدل سيل تادايع نودب نكلو رابتخلاا يرتج تادايع )39.4%( ةأرما 21333 رابتخا ءارجإ لىع ةردقلا مدع ةيحجرأ تناكو .يرحتلا ءارجإ :ةيحجرلأا ةبسن( ةحصلا لىع ظافلحا عقاوم في يرثكب لىعأ يرهزلا ىوتسم لىع تامدلخا فيو ،)25-4 :95% ةقثلا ةلصاف ؛10 ،)1000-10 :95% ةقثلا ةلصاف ؛33 :ةيحجرلأا ةبسن( ةدلبلا لقت وأ يواست ةيونس تادلاو اهيف عقت يتلا تامدلخا عقاوم فيو :95% ةقثلا ةلصاف ؛1.002 :ةيحجرلأا ةبسن( ةدلاو 1000 نع تلادعمب ةمدلخا صاوخ سفن تطبتراو .)1.003-1.001 .)0.01 نم لقأ P لماتحلاا ةوق( يرحتلاب ةيطغتلا نم ةضفخنم لىع ةردقلا ايهدل ناك ةدلاولل ةقباسلا ةياعرلل ةدحاو ةدايع طقف ةيبلوللا يرغو ةيبلوللا اييرتكب نع فشكلا تارابتخا ءارجإ .يرهزلا صيخشتل قفارلما نم ًادج ليلق ددع في حاتم يرهزلا نع يرحتلا جاتنتسلاا متت ثيح ،ةدلاولل ةقباسلا ةياعرلا مدقت يتلا ةيساسلأا ةيبطلا ببسبو كلذ ءوض فيو .ينصلا بونج في نادلولا ةيبلاغ ةدلاو عيسوت تايولولأا نم دعي ،ةقطنلما في يرهزلا عوقو تلادعم ةدايز .ةعسرب يرهزلا رابتخا ءارجإ لىع ةمدلخا ةطقن تاردق Bull World Health Organ 2011;89:798–805 | doi:10.2471/BLT.11.089813 803 Research Syphilis testing at prenatal clinics in southern ChinaLi-Gang Yang et al. 摘要 中国南方医疗机构梅毒测试的可用性和执行 目的 旨在调查中国南方医疗机构的梅毒测试能力、筛查覆 盖率和梅毒测试类型。 方法 广东省14个市中的11个市参加了本项研究。所运 用的梅毒测试能力、筛查覆盖率和梅毒测试类型方面的 数据从提供产前护理的所有类型公共医疗机构（n = 109 ）处收集。本文研究了2004-2008年间分娩的共计494 680名妇女。 结果 2008年，54 196名孕妇（43.1%）未接受梅毒筛 查。这些孕妇中，32 863 （60.6%）前往的是没有任何 梅毒测试能力的诊所，而21 333 （39.4%）前往能进行 梅毒测试的诊所但却没有接受筛查。下述医疗机构无法进 行梅毒测试的可能性较大：卫生站（比值比：10；95%可 信区间:4-25），乡镇级服务站（比值比：33；95%；可 信区间：10-100）和每年分娩数量达1000例的服务站（ 比值比：1.002；95%可信区间：1.001-1.003）。这些 服务站的相同特征是与较低的筛查覆盖率相关（P < 0.01 ）。仅有一家产前检查服务机构有能力用于梅毒诊断的密 螺旋体和非密螺旋体检测。 结论 在中国南方，提供产前护理且为大多数婴儿出生地 的基本医疗机构中，仅有很少的几家机构能够进行梅毒筛 查。鉴于此情况以及该区域梅毒发病率的不断上升，扩大 医疗点快速梅毒测试是当务之急。 Résumé Disponibilité et recours au dépistage de la syphilis dans les établissements médicaux de Chine méridionale Objectif Étudier la capacité à effectuer le dépistage de la syphilis, les taux de couverture du dépistage et les types de tests syphilitiques utilisés dans les établissements médicaux en Chine méridionale. Méthodes Onze des 14 municipalités de la province de Guangdong ont participé à cette étude. Les données relatives à la capacité à effectuer le dépistage de la syphilis, à la couverture du dépistage et aux types de tests syphilitiques utilisés ont été recueillies auprès de toutes les sortes d’établissements médicaux proposant des soins prénataux (n=109). Un total de 494 680 femmes ayant accouché entre 2004 et 2008 ont fait l’objet de l’étude. Résultats En 2008, 54 196 femmes enceintes (43,1%) n’ont pas subi le dépistage de la syphilis. Parmi ces femmes, 32 863 d’entre elles (60,6%) se sont rendues dans des cliniques ne disposant d’aucune capacité pour effectuer le dépistage de la syphilis et 21 333 d’entre elles (39,4%) n’ont pas subi de dépistage, bien qu’elles soient allées dans des cliniques aptes à le réaliser. La probabilité du manque de capacité de dépistage de la syphilis était beaucoup plus élevée pour les centres de santé (rapport des cotes, RC: 10; intervalle de confiance de 95%, IC: 4–25), les services au niveau communal (RC: 33; IC de 95%: 10–100) et les services réalisant moins de 1000 accouchements par an (RC: 1,002; IC de 95%: 1,001–1,003). Ces mêmes caractéristiques de service étaient en corrélation avec des taux de couverture de dépistage inférieurs (P<0,01). Seuls six (5,5%) types de services de soins prénataux disposaient de la capacité de mener des tests tréponémiques et non tréponémiques pour diagnostiquer la syphilis. Conclusion Le dépistage de la syphilis n’est disponible que dans très peu d’établissements médicaux de base qui proposent des soins prénataux, dans lesquels la plupart des nouveau-nés de Chine méridionale voient le jour. À la lumière de ces informations et de l’incidence croissante de la syphilis dans cette région, l’extension du dépistage rapide de la syphilis aux points sanitaires est une priorité. Резюме Доступность и масштабы тестирования на сифилис в медицинских учреждениях южного Китая Цель Исследовать имеющийся потенциал тестирования на сифилис, показатели охвата скринингом и виды тестов на сифилис, используемых в медицинских учреждениях южного Китая. Методы В исследовании приняли участие 11 из 14 административно-территориальных единиц провинции Гуандун. Были собраны данные о потенциале тестирования на сифилис, охвате скринингом и типах тестов на сифилис по всем видам государственных медицинских учреждений, предлагающих услуги в области дородового ухода (n = 109). Всего были обследованы 494 680 женщин, рожавших в 2004–2008 годах. Результаты В 2008 году 54 196 беременных женщин (43.1%) не были обследованы на сифилис. Из этого числа 32 863 женщины (60,6%) посещали клиники, не обладавшие необходимым потенциалом для проведения тестов на сифилис, а 21 333 женщины (39,4%) посещали клиники, в которых тестирование проводилось, но не проходили скрининга. Вероятность отсутствия необходимого потенциала для проведения тестов на сифилис значительно выше на гигиенических станциях (отношение шансов, ОШ: 10; 95% доверительный интервал, ДИ: 4–25), в поселковых службах (ОШ: 33; 95% ДИ: 10–100) и в службах, принимающих до 1 000 родов в год (ОШ: 1,002; 95% ДИ: 1,001–1,003). Эти же характеристики медико-санитарной службы коррелируют с более низкими показателями охвата скринингом (P < 0,01). Только одна клиника дородового ухода обладала необходимым потенциалом для проведения трепонемных и нетрепонемных тестов для диагностики сифилиса. Вывод Лишь в очень немногих медицинских учреждениях базового уровня, где предлагаются услуги по дородовому уходу и появляется на свет большинство новорожденных в южном Китае, доступен скрининг на сифилис. Учитывая вышесказанное, а также принимая во внимание рост заболеваемости сифилисом в данном районе страны, расширение возможностей для быстрого тестирования на сифилис по месту лечения является приоритетной задачей. Bull World Health Organ 2011;89:798–805 | doi:10.2471/BLT.11.089813804 Research Syphilis testing at prenatal clinics in southern China Li-Gang Yang et al. Resumen Disponibilidad de pruebas de sífilis e índice de aceptación en centros médicos del sur de China Objetivo Examinar la capacidad para realizar pruebas de sífilis, evaluar las tasas de cobertura y los tipos de pruebas de sífilis utilizados en centros médicos del sur de China. Métodos Participaron once de los catorce municipios de la provincia de Guangdong. Se recopilaron datos sobre la capacidad de realizar pruebas de sífilis, la cobertura de evaluación y los tipos de pruebas de sífilis de todos los tipos de centros médicos públicos que ofrecen cuidados prenatales (n = 109). Se estudió a un total de 494 680 mujeres que dieron a luz durante el periodo 2004-2008. Resultados En el año 2008, 54 196 mujeres embarazadas (el 43,1%) no fueron evaluadas para la sífilis. De estas mujeres, 32 863 (el 60,6%) acudieron a clínicas sin capacidad para realizar pruebas de sífilis y 21 333 (el 39,4%) acudieron a clínicas que realizaban la prueba, aunque ésta no se les realizó. La probabilidad de no disponer de capacidad para realizar la prueba de sífilis era muy superior en puestos de salud (cociente de probabilidades, CP: 10; intervalo de confianza del 95%, IC: 4–25), servicios municipales (CP: 33; IC del 95%: 10–100) y servicios con ≤ 1000 partos al año (CP: 1.002; IC del 95%: 1.001–1.003). 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