Biennial workplan 2008-2009: area of work: epidemic alert and response

tWORLD HEALTH ORGANIZATION REGIONAL OFFICE FOR AFRICA DIVISION OF COMMUNICABLE DISEASES PREVENTION AND CONTROL MULTI DISEASE SURVEILLANCE CENTRE (MDSC) OF OUAGADOUGOU BIENNIAL WORKPLAN 2008-2009 Area of Work: Epidemic Alert and Response 23 April2007 @ 1. Introduction The African region is still confronted with a high burden of communicable diseases while non- communicable diseases are also on the increase. In order to strengthen the surveillance system in the African Region, the Regional Committee for Africa adopted in 1998 a regional strategy on Integrated Disease Surveillance and Response (IDSR) through the Resolution AFRO/RC58/R2. In the same line, the Multi Disease Surveillance Centre (MDSC) was established and based in Ouagadougou in 2002 at the closure of the Onchocerciasis Control Programme (OCP), in order to preserve the gains achieved by OCP in Onchocerciasis control and, to achieve a better coordination of disease surveillance activities in the African Region. Actually MDSC is focusing on surveillance of Onchocerciasis and Meningitis. Onchocerciasis activities are funded by World Bank grants, while Meningitis activities are being funded by the Meningitis Vaccine Project (MVP), a partnership between WHO and PATH. 2. Objective The objective of the MDSC is to serve as a Laboratory-based centre of excellence and a reference point for surveillance with the capacity to forecast epidemics, and monitor the occurrence and spread ofresistant strains. 3. Strategicapproaches - Pursue onchocerciasis surveillance activities in order to detect and combat any recrudescence of the disease in the ex-OCP countries - Provide technical support to countries in disease surveillance and laboratory diagnosis; - Identify and monitor causal pathogens as well as their type and sub-t1pe - Monitor the antimicrobial susceptibility of aetiological agents of priority diseases; - Conduct research activities leading to a better understanding of the major priority diseases of the Region 4. Expected result and indicator of the work plan During the current 2008-2009 biennium it is expected that MDSC serves effectively as a Laboratory-based reference centre for disease surveillance in the African Region with a "functional bacteriology, virologt, parasitologt and molecular biologt laboratories" as indicators. To achieve this goal, the MDSC is targeting to deliver 8 products through 26 activities. The total budget is 20 940 140 USD. The available funds allotted are estimated at 891 500 USD. Extra budgetary funds are estimated at 17 972 200 USD. The gap is 18 853 640 USD. 5. Issues and challenges The issues and challenges to be faced by MDSC in order to achieve its expected result include: o Establishing a strong foundation of MDSC a laboratory-based centre of reference: o Establishing governance structure of MDSC o Ensuring staff salaries o Ensuring facility costs o Ensuring duty travels, transport and logistics 2 o Maintain the laboratory equipment o Maintain the infrastructures and buildings o Organize the statutory meetings and report to the new established governance structures: the Steering Committee and the Scientific Committee. o Developing at MDSC a hub for epidemiological information sharing in the Region using the Information Technologies (IT). 6. Work plan (see attached tables) o, o ooI ooPo(\t ooI ooo o € ooo oo ooo ro otI(\tlo 90 ooIoto ooo o ooo oo ooo o CE ooo o r{) o UJz o oo dlx ooI oePo(\t ooI ooo o @ ooo oo ooo l.l, oooL (o ooIo ro ooo o ooo oo oo Po(Y) ooo o ro ou o UJ oJ oooi- (o o IJJ r- =e o- ooI ooIoN ooI oo9o@ ooIoo ooI ro otP o)(o sN ooIo ro ooIo ooIoo ooIo(, ooIolo ulz UI =F oz UI o,ooq NI (a o)ooq N: (r) o)oo c! N I (9 o,oo c! N: co o)ooq NI (f) o,oo c! N: (a o)ooq N I (f) o,oo c! N I (f) o)oo c!(\t I (f) o)oo ol NI (9 o,oo c! N I (r) o)oo o{ N I (f) tr F U) @ooq q o @oo c\] q o @oo c! q o @oo c! q o ooo c! q o @oo c! q o @oo c! q o @ooq q o @oo c! q o cooo c! q o cooo c! q o cooo c! c o I oo TIJ D n ,)L 'n IJt o oo oo o o o o =o o o o o ul !0 az o o-o uttr .= o .= o .= o .= o .= o .= o .=o .=o .=o .=o .=o .Lo ogt =9FU)o< <Fttr =U' ;*Eo cA -E=!I'I 3 e .Ec;=E =CD U ()s3 3E o Goo EHo -. -o.FUc ar f .Y fr 8E o Y= -o--oo!zoUJEE oN =o89,E> EgcooFgE ooo=ol iE ooca)ox =;ocN'= O' c !.=$tEoo E o .o (U .E'= cEOc oF(/) d $ l., 'E 9.c(E.9;o)> I{ o< E G oL o o ct)fc -LoE sE 'Eo o(nO)^ o> o U)o =o SP ^lEEhb6 o tA Z"o o o- E o) EEAL6ofiE oocoLoq) o E .o:o o aDg) cEoq) .eEg_ cui9o (l)+ 'E(Jy) o-(l) t _o6= FbEcLo(t, ,n co >\ E:g 'j:otr :1b.9I cEf QEEE Ew5 @. u, o)c =E5L -oO e5 fC 9'ro r.x E ogtt o oooO fi E= sbEo>=trt o *:o: o oo s G,o o J oc UJ E (E J E' o) otr UJ oo ='6* aEo5o oo otr IIJ G o ooo oo ooIoo ooo to(o ooo o 6A ooPolo ooI ro oe9o ooIoo ooIot(, ooo l.) o IJJz o oo trx ooo oo oo s)o c, ooo to(0 ooo o(t, ooPoll) ooPlo oeIo ooIoo oO9o[r) ooo lo 6u o IIJ Fo olll r- =e o. ooIoo ooIoe ooI u)(o ooIo(n ooIo u) ooPlo ooIo ooo oo ooPolo oeo lo UJ =UJ E tr oz IJJ o)oo c! N: (a o)ooq N I (9 o,oo c\ N: (a o)oo c! C\ I (f) o)oo c! C! I (f) o)oo c! NI (f) o)oo c! N I (o o)oo c! NI (a q)oo c! N I (a o,oo c! C\ I (f) Ftr o @oo c! q o @oo c! q o @oo c! q o oooq q o @ooq c o ooo c\l q o @Oo c! q o @oo c! q o ooo c! q o @ooc! q o IJJ E ,oozoo o.t) IIJ u o aF zf, t. o t o JF o o o =o v.l U) IJJ o atz or .t, IJJt .=o o o o o dl J d) J co 5 d) 5 d] J U, IJJ L >-g)-@o<<FI of U' oLf, .D bo -o(U=c orE9 =otro C.=6'F =iE8 o<)oiE o) o-oootr ==a)ooci8 I oa eB eU o E'ii o!(, EE= E P6 5 Ee EE .=o EE =roro oZ (D rn _oo,EE >ah58 j q)fo)bo --i CbF *gc.E !8(EFE oEN 2a65 oE o,.9 o-.c 6 E EE EE6 o e-o .ut GU' ,\ a-EF -Uo o>iPg, €E eXG o)f,-o o- oq.)LJ- = oO- Lo foq) o E o €o -go(E> oc7)ooootra IctsO tkooy(E=Eo(a3ieth soqrtr5's'd oI &a Ei a"0E bPPE .= >o!l-o c El4 9' fr;f qp E-? 6 rgE E o UJ E =o E o CLotr G o =oc UJ t, >rCE,, o o-9 b t a3€ EEEI EE uO! >o cL 3 ED..= -9 I 9'Eo: o E> O'='=t EE e@'6. o o- o oo9o ooo o ooo olo ooIo ooo io ot ooo o 0oo o c) ooIot o LrJzI u, U' Ex ooIo ooo o(? ooIo oo9 rr,N ooo o ooo o c, ooIo$ r0 u eoo o o o UJ Fo olus =go. ooPo ooo o ooo olo ooPo oo9lo(t ooo o ooo o co ooPorl uJz IIJ = oz UJ o)oo c! NI (f) o)oo c\ NI (f) O)oo c! NI (f) o)ooq NI (f) o)oo c! N I (r) O)oo c! N I (a o)oO c! NI (f) o)oo c\ NI (f) Ftr Fo @oo c! q o @oo c! q o @oo c! c o @ooq q o cooo c! q o @oo c! q o @oo c! c o @ooq q o UJ o tOozoo o-o uJ u tla tla uf U) tfa E,la tfa trf U) E. o uJ o oz oLo UJu c0I c05 m1 dIJ d]I d]J d]I c0J ogt =9l-oo<<F a @Do L .v c;#6sEOo gHEi E ? *,v ES i-B - o EO(U,-€-:d> E€6 (Do Ea"E 6 c! c oor IE EE E *bF orbE=E.c =8 iESH !o>bg >r= P fi€ , =c) ofi u=.9 SEeE E.E8 H;E:5 o a& 8Us(E ^-oolJ o EuEs L!.-Lo cF (u E 3 6.Eooo(/,EroE I o o) =of,g a -- =.lJ OH',_: = .6.9 g >6 E E EBe ::E'56a X e,flE g6d c b 5I f c'= o<t o o EJ E o oo99-l!o- ;EE oEo .=oqf o).LO:E (E €E; brE -coE'6 po .l= 6)F .1, ti) o-o e 3-f aOO- .9 8,1c-r *g{8<66> 8,4 GO _cc 8E o:NXg .EEE gEE 6 9g ogI E Fo r9nE EEHflE$ -'Ee H, og E e $raorts- = ul ^-YG.Yo -9-EflEE95EbEooOE o E" o=.=ilg E o.oSri HEEEEO ,ts= \o o. o ooo o c, ooo lo oo9o ooI ro(a oo9o ooIo ooIo oo9o o llJz o oo Ex o0o o(v, ooo ro ooIo ooI la) c, ooIo ooIo ooIo oo9o tru o UJ o o IIJ s ieq eoo o(v, ooo lr) ooPo ooI I'O(Y' oo9o ooPo ooIo oePo lrl =Lrl =F oz IJJ o)ooq NI (f) o)oo c! Nr (9 o)oo c! N I (f) q)oo c! NI (r) o)oo c! NI (f) o)oo c! N I (o o,oo c! NI (f) o)oo c! NI (f) u o oooq q o @oo c! q o @oo c! q ro @oo o! q Fo @oo c! q o @oo c! q o @oo ol q o @oo c! q o u, dt ,oozoo o.o UJtr oFz tu oFz tU oFz UJ oFz IU v.fa tfa trf CJ) ufa IJJ o oz o o-o IUt d] J d]I d]3 c0s d)J d]I c0I d]I U'g =9l-oo< <F I ofo .g .gEo oo oq'0 -9k b o.9xoftr E -c c)..:gE ()T.Yfc=o(IloE(D o E e€ sehqroo) J9 ='5 >6E hE 5 E 8E 3E +}E5E E3;BE -b .txE: e IEIx.E:s uHE s#c6'5HbgF(l (rf, c olg<t o (, o o-.:J t o(L U, (,)O) 6 L ar-= Hg3 3 > E'b gtP'E 9E =o:z(a6 9t E .i-(JEOllJ(/)oo_ Lo f8e ob=E-0) ^O-'.='E (o .O (EE e€ F fiE E rO o9 t- u)oo)BtrctooEoO cro.9i O'- ar! -> =fiE E Pa Ef;E 8:E B= g uEb EEEc=Oo x-oo5(u o ,EE eE i, = E.szo o-oQ E*o E-o -'3E o E B Be--o_-c c F AEE E U)ulotsE l-ooa E.s EEgE E E gE gEEE YE >:' .E H 8 EA8e=3Xt rgH E'E o- (, ooIo u? oo0 o(\t ooo o o ooIo u? oo9o(v) o IJJzI U, U) ox ooPo ro ooo o(I ooo o oo ro(t) c) oo9olo oo9o(a otr o UJ o oo ro o) C? olug =e o. eeIo u) ooo oN ooo o ooI o)fi, ooIo rr) ooIo c) u.lzf, UJ = oz IJJ o)oo c! NI (r) o,oo c! N I (9 o,ooq NI (f) o)oo c! NI (r) o,Oo c.l NI (f, o)oo c! NI (f) E, o @oo c! c o @ooq q o @oo c! q o @oo c! Fq o @oo c! q o @ooq q o ul o ,oozoo o-o UIt trfa oFz LU oFz trJ oFz trJ d] 3 o ut o oz o o-o IJJt d) J d) J d) J oFz I.IJ oFz LU E,lo U' uJ t- =91-O()<<F Io =o L_ '- (E,. lz P EU , EEE* E6J^L/-c S€'EEEEsO00)^..rr- &EE E E E!+ o-I, -c o-'Ed.E E 3 A E L o€ I,IJ O(,) .o .E aE - H.euox(,of X o€E = c-cci o)o -Q E.o 6(, oa, o. I ac>'E 9E LF =E(,b9t o.a cl! o YX',D 8E E co'z =oo-E E fiaE E H Es 5EE e s .J F.= o.L(/) 66.>< EEEB6,E ;nEeEis B,r E!,3eiEEEs ;e:EgE;E p .hC '7aO ,E E =S E sE* agE gEh E f E EE u8E; E;E @ lr.l E o .2 *E 5 * EEEE o EEEE o. o ooIo ooIlo ooIe ooP(o co .I= ot!z o oo c0x oo9o ooo io oo9o ooo(0oF o u, o UJ Fo o llJ I =e o. ooIo oo9 lO ooPo ooI(o @F IIJz IIJ =tr oz IU o,ooq NI (9 o,oo o{ NI (f) o)oo o{ NI (f) o)ooq N I (o o,oo c! N - (o o)oo c! NI (a o)oo c! NI (f, O)oo c! N I (f) Fu o @ooq q o @ooq q o @oo c\l q o oooq q o @oo c! q o @ooq q o oooq e o @ooq q o lrJ dt ,o 86oo lrJtr o t o trla o oo o o e dII .= o oo O ooo c0) .= o ooo ut dl6z o o.o l,utr t.fa E,f U) d)I E,fa trlU) trlo trla ufo og =9l-oo<<F I to =o pb 5;E; H E.go-.-6=oE P o qx> ;cE--*c EEEEEEg cth E;E, .0 P.= a!e{ OCeF ..L.= - c E eee '-c(!OE (D nr.N :eEeo!Eo : l/= -IIO()E p-9 6.9 -E 6.Xo o_= o o.9 EEFo -4.=€ €;,E EEE t ts 6EE€ th o 'E c Jvcoxo-c - o:It5 6 0.E #LL,^I b.e= EX(iDC)E 6 0)pl? q, o.i(JOo(,) o OE hsa8 eE;s(UJ sHootr5 oS -F $E= ge d 9.E =trE! Eex & E H PEE9 b,Eg s EE ds €E g,H i 'E E€ 'odg) oE* !gL - (Eic -^ L: tuHo)- o E gHi O- EE H =E E oc ; E dE€ E.E€# =ceo6o:z -r o- *!l .L U' IJJ =o tEeEiI P:E = ;E$g O o- o ooo oo ooo oN ooPo(\t oo0 oN ooo o (f, ooo o ro ooo olr) o IJJzI v,o dlx o0o oo 0eo oN ooPo(\ ooIo(\t ooo o ct, ooo o u) ooo olo ot o IJJ o o llJ g =e o- ooIoo ooPoN ooIo$t ooIoN ooPo(Y) ooPo u) oo9o U? ttJ =ul =F oz IU o)oo c! NI (f, q)oo c! NI (a O)ooq NI (9 o)oo c! NI (a o)oo c! NI (a o,oo c! NI (o o)oo c! NI (9 tr Fo @oo c! q o @oo c! q o @oo c! q o @oo c! q o @oo c! q o @oo c! q o @oo c! q o UI E ,oozoo o. @ utt o aF zl .= o =o (n J dl J t = d) J d]I uJ trl oz oGo UIE o .= o o tla oFz tu oFz uJ oFz IJJ to IIJ L >-gl-U)o<<F I @ =o c .9 N =6 o) Eco oo o 9ELo- s3 5oJo =oL -o=Y'G o.= .cEC E EE o o)g)o cc _LO EE. 8Eg? eaa9E LoxfrE8 coo E 5E= 3 E.s b 2 9.eEatd H IE3:IP -o.= -19 (U 0Gcfco6'6 Pq qI,JJ.5 Y E E .9 XEUIE L) ar!!= oro!E^- 9 PEgP 6_ E'6E'=9 E ^r qc f,Q-OO(/, .s o .9 .b_co a 38eoEE6 (u REE :€L ,i6A at, E.u, orP '=o eb gC oo)5aEE(Dxu6 .s (t, o) .=8., 5's, Eo o.eo6?i E'E b o-o Cr,o_p ol'; >(/) dt.c o EI E Fo o .9 o=(J =68I E orEH g,r 6'.8_ o(E o- Eg as:s E PEE-E h EE " E gEAs a-o o o. o ooo o ro ooI(0 ooItoN o ooo o o IJJz(, oo ox ooo o u) ooP(o ooP roN ooIll)(o ooo o 6 u o IJI Eo ooP ro(o olll r- ie o- ooIolo ooo io ooI ro(\ ooIto @ ooPo ooIo(v) LrJz =ul =tr oz IJJ o,oo c! N I (o o)oo c! N I (r) o,oo c!(\t I (o o)ooq NI (9 o,oo c! N I (f) o)oo c! N I (f) tr @ @oo c! q o @ooq q o @oo c! q o cooo ol q o @ooq q o @oo c! Fq o IIJ dt ,6oz()o o-o UJu d) J d) J o oFz tu =o dl J =o dI J o d) J IJJ o oz o o.o IJJt oFz tu oFz LU dt J E,fa tfa trfa o UI L =9t-oo< <F Io =o .EE?-.e fl EEg pes2-E Eo 6 piEoEp c 6.9 9 8EJ=6tgE P€8Eg€€(J o<t Co.:(U c o EE EE E r E ["*E =oo<)i sro Le.-U sEgB rE ', HE-c+ 5 o) E seB #EE- gE 8EH (- o.\s (D \{9P \EEb:\PPFg;; EEEEE =(.)yro.==E=1r > C =SH8;Ed (t) t' 9_> E R o^6VFL o- 0)'; 34o _c E .!1.L- =zo o cco- = o'- v: E EOHS -^=-cr.=< .t A-=;E4956Y f .= o (E(J oi=ol,L .Ed .9 ^E o) -- j9 .9^ ='#?EP I g; or EE aBEd* F=;,= = (,,-oLJJ o UJ E Fo E -o - E o 3'E Cs;HIED: tr o.=ES O CDar # g r; E o -E N o- o ooIo ooIol.) oo !o ro ooIo u) ooIo oo9o oo9olo oo9oeo + o lLtz o U'o @x ooPo oo9oIo oo(o 'lo ooIo ro ooIo ooIo ooIola, ooPoook o d, o IIJ Fo ooIo ollJ g ier ooPot ooIo ro oo !olr) ooIoto ooIo ooPo ooPolo oo9o0I\t ]U = 1U = oz IIJ o)oo c! NI (o o)oo c! NI (a o)oo c! NI (f) o)oo c.l NI (f) o)oo c! NI (f, O)ooq N I (f) o)oo c! NI (f) o)oo c! N I (f) u, o ooo c! q o @oo c! q o @oo c! q o @oo c! q o cooo c! q o cooo c! q o @oo c! q o ooo c! q o lrJ @ ,oozoo o- U' IJJE o d] J o d) J v. o Qc0I .: o ooo .= o ooo E,f,o oo o o tla uJ dl6zo o-o ttJt trfo tfa ufa trfo tf U) E,)o .:o .=o o ut L =9FU'C'<<F a o :) U' l-a mC (U O.L (D'E = E PKE(ELao= c.= s ;e.e d€tu^ 0) == cN X G'= E()io)(UuvEqroE - L).L o o ooa0-B e8= 'Ec3 '6oo.. t o.!P U E FE E Eg HE 8sE 5 st L o -F €E oF -o5aFo9U) -y. ! .=QdP E5;-i_o c EE E >- oEA EE-; E€E^ EfrEEEE 3 E 6 5 6-. E$E;E8 .E ()E of oo!Oa rFE 8E6atro o-> arr - -9oEEo -c !Z'; EEEE - o.Skc>. .-Y'6 o H B;&e tL !.-o;E o oE .NoPcoxo(,=or(u E.6E€h LCf5*g ;H.,) C:O!2 O (E0 Ei eH>l E eEss, = g pRz EE.EUE o .E tLo ccooo_(EE-L)Ecti 6 .9,jco :oooCFE .YO(E(JE () o IIJ E o o s.E = E !€s EgE t d'E'= o co o. (9 ooIoN ooI ro(\t ooPoN ooIo ooPo oor t ooIo ooIlo o IJJzIoo Ex ooIoN ooI roN ooIo(\a ooPo ooPo oo s- t ooIo ooP u) od o IIJ Fo o llJ g =e o. ooIo(\t oo9 rl:,6t ooIo6t ooPo ooIo oor !t ooIo ooI u) UJz ul = ozu o,oo c! C\lI (o o)oo c\l NI (o o)oo c! NI (a o)Oo c! NI (o o,oo c! c{I (Y) o)ooq N : (7) o,oo c! NI (r) o)oo c! NI -(f) Ftr Fo @oo c! q o @oo c! q o oooq q Fo @oo c! q o @oO c! q o @oo c! q o cooo c! q o @oo c! q o UJ o ,oozoooo IJJ u oo e d) 5 o .=o ooo ooo o .= o ooo d)I t :) U) v. tla o o oo UJ dt oz oro UJt E,fa tlo tf,o tl U) .= o .=o =o o U' IJJ L =el-o(J<<F a @ =o g 9o etsO.(D s C > iE o'-cu o c E - o-c o= E $PE$ EE E = E ,*e=EE o E etE'5 or E $ E sh X.p*E s ^=.I15 c FE ilE g lI oiE o (uLJ () (DE () btso u, >o)I I E .Hb ! I q8. m u, O! o': r e H p,fi.E,EbE=II -uV -- -Y o (E= O (E(J U, >c:E (J 8,<.*o c'-- 'EOoC E; E8i: sRE€.9p € r St o p'=x -P.J o oL.' (, ()N ocg, o'6 .! o_. !1 tr6 H F.s)> ez "E.E p or6 6 L -.-!!.() (Uil9=i.E.s p f .e.6o- oBHs Ee atEE:E €'E 5rhocf!i o-o(D6 7 8.s g9, o-= E(/) E.P g c o'6gEE 6a su TEE o-9ooo>9,ooEO)ao oE o)cE;o€ o r,u o oP5.e: :! E5e s .EEgTg5 r.tsEEE d E 8.Eo Fo Eo2U) c ;39 'E tnoE oE' \t o. o ooIo ooIo ooo io(r) ooIlo ooo o ooPo$t ooo o ooI ooe o o IJJz o oo ox ooIo ooIo ooIto (Yl, ooI ro ooo o ooIoN ooo o ooI ooo o dt u o IIJF o o llJ u =e o. oe9o ooIa ooP u?(t, oooh ooIo ooIo c{ oo9o ooP ooIo IJJzf, IJJ =F oz ]U o,oo c! C! I (f) o)oO c! NI (9 o)oo c! NI (o o)oo c! N I (o o)ooq N I (a o)oo c! NI (a o)oo c! NI (f) o)oo c! NI (f) o,oO c! NI (f) Fu Fo @oo c! q o @oo c! q o @ooq q o @oo ol q o @oo o{ F e o @oo c! q o ooo c! q o @oo c! q o @oo c\l q o IIJ o ,U)ozoooo utt, o o o o tf,o =o o =o o IIJ o oz o o-o IJJ u, o o o oo O oo o oo o o o ooo O oo o oo @ u,t L =etso(J<<l-Io =o 9E?o6 cZ = o>* -.'E (,o_E !q >0) #.= o) s# =ES gE5 .oEEP N6Ple O (5.Y E ai .Yb'i c q! ,) EEP PDocEoo(/)6Eoc ; d.qp.o.E h:= (E 0t c.= -o oE .; g-a c o o(/,o AEc(EEoE66c o.S.9 EEEg E€ gg cOO flEobaE oEE E E'=EcOl .c b._E €EEo.E E LO.O EE E d-e9E o-X8.E .3a 9'6 !uf€E >P(uE -o! =Q)o.EE9 SEqrEEX =J-st9E '^-vLtJE (E LAy .?EEL).^>I g3 e >E;.0atfrE(! o :.!? YE (JO -!+c o fJO(EO. o .E E'qr(U o-c 'Eo =x50) 8E EEo-F 9E(/) .= o UJ E =o $=E s EE e sEgEo= I =€ J otr EE "OGEDtrtrE -tt!;e6otriE.I O>oo5o (r) o. (9 ooo ro ooIo(o ooPo u) oeIto ooIo ooo olo ooIo$ o ulz o oo ox ooo lo oo9o(o ooPo ro ooo io ooo o ooo o rO ooPo$ ot o ul o o IIJ s =e L ooI U) ooIo(o ooIo rO ooIlo ooIo ooIolo ooIot UIz IJJ =F oz UJ o)oo c! c! I (9 o)oo c! N I (f) o,ooq NI (r) o)ooq NI (a o)oo c! NI (f) o)Oo c! NI (o o)ooq NI (o Ftr @ @ooq e o @oo c! c o @Oo c! q o @oo c! q o @ooq q o ooo o,l q o @ooq q o ttJ 6 ,U)ozoo o.o IIJ u tfo tfa tfa tfo tf U) c0 J tl U) d] J trla lrJ @ ozooo IIJt o o o = =o = =o = =o =o ogl L >-gFU'o<<F aofo (f, og E g gE 9 g L-.o e E 5 ea= e_.?2 g: E H a.===.=- > fEE BEE€<L (ut C) ()= (, oc.9 or s,E i E ";g€f c< o)O = >,'= : E= x.85E390S<d.Eas o ot'ooo orE P orc'E = q, o-sL oo-(f) o) -P<E 6F -.- E d I agr! SEXegEE 3s<L (,) O-u, E o EO -o!+ (E '-gts(U o(,,= EEEoao= a U f$E=- .=4 0-G(u(l)== o*E 6drE 8, o .9gr= .-Jo_oo-o9o -- al,lgo .:2 () B'EdE *o)E.E Eo€!€lEL9 E€ E or 9.e .LoU) = t-bqfo9Oc<.(,,(U -o$x3r(Ei (,, c -cr(l)(,)(Ilo qDo-E6EHC!,I 6oh4 Ee e=gE U' gt E o o "E:8E€.8= E $5; ,E.EE. o oE.€ -E E 8.98 *" &.9 Bt s; aE E E EE=90 !, \o o- o ooI U) ooI oooh(o ooIo ooo ro N ooo lo$t ooPlo ooP o UJzI U, v, ox oo9 r(, ooP ooP rr)(o ooIo ooo() N ooo loN ooo[r, ooP o u o IJJ o o IIJ r- =e o- ooP u) ooI ooI ro(o ooIo ooI ro(\t ooP u)N ooI lO ooI ulz IJJ =F oz IJJ o)oo ^lNI (f) o)oo c! C\|I F (f) o)oo c! NI (9 o)oo c! c{I -(9 o)oo c! NI (r) o,oo c! NI (9 o)oo c! NI (f, o)ooq NI (f) o,oo c! c\I (f) u @ oooq q o @oo c! q o @oo c! q o @oo c! q o @oo c.l q o @oo c! q o @ooq q o @oo c! q o @ooq q o ttJ o tc)ozoo o.olutr dt J t :)a d) J v.f U) t :) U) O oo ul U) ooo tf, U) o oo tfa tf ao o o o o o o o o o o UJ o azo o-o ulu o =o oo oo oo =oo oo =oo oo o IJJ L =9l-oo<<F I o =o E BEEE$t$ p cah(I, o.o) c.U) E(rr-\ c s= d E 3B = o.:z .=ooo =_o;PE:ioo6ae o-ko lJ.. -c iD;o .v.-l,c$ 9€*€sE o o o;.=c f=€Eb0 .N E o'= 3 of,c E h o o c.= g€€EE Eg -O6tr o-LL ^o-<.<2 -{€6 X'6, k=.LvC- 5Pg 35r!o()ooq)d5B I .E oo caE^ .oEq9 -dgv,.. (E'-5 G '?{ o o)s11 6,'E.E € q c = o au.L 'E E= llzo c c= L E 8 E Hid E) Lo L o oL o o.o (L c o E t'roo 8.( 3 or6.F c-ol! E Eg EE; sH6a. E+j ;=cO o0D cO .9> Eq)os oo o, o -6o0,o!E ==g(D- (D €33 e-O(a qral E BE =:lro-t< o LrJ E o =9: o, o.= te*gg€ ".lioX E=- I6.c.9tlax trttaED= o '6 e= 6E G' r- o. o ooI ooIoo oo9 ot so(r)lo 90 @ o IJJz(9 U'o ox oo P aoPoo ooI oo 9{N I o E, o uJF o oo !o o,@ o llJ r_ 4e o. oo9 ooIoo ooI otFo$Io st IJJ =ut =tr oz IJJ o)oo c! $tI (f) o)oo c! NI (r) o)oo c!(\I (a Fu F @ @oo c! c o @oo c! q o @oo c! q o LrJ tr ,oozoo o. U' Lrlu aF zf, aF zf aF zl uJ o oz oLo IIJt. .= o .Eo .=o o UJ l- =9t-oC)<<F a @f U) 3o oE b.oh5 a= E .0) ua 8c> e8(l)-of o 89, =8 .&e EE53 c .9 o L o -ct _^oE 6.9o= oEg6 oc c- o=t> o IJJ Fo Es: FeIuE6 aa